Genes link bipolar and schizophrenia once thought unrelated Dcc - Wire HEAD TOPICS

Genes link bipolar and schizophrenia once thought unrelated

10/23/2022 1:31:00 AM

A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings

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Arizona Daily Star

A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings But a growing body of research shows that bipolar disorder, schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings as well as overlapping symptoms and signs.The theory that they exist on a continuum has gained ground as more and more studies have found that variations in some of the same genes influence how susceptible people are to these conditions. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. Read more:
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Read more >> Genes link bipolar, schizophrenia, once thought unrelatedBipolar disorder is known for causing extreme mood swings. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Schizoaffective disorder includes symptoms of both. Amy Schumer Admits Son Gene Is 'Not Impressed' With Her Glam Life - E! OnlineWhat does Amy Schumer's 3-year-old son Gene think about her being famous? Scroll on to hear her answer. He's not used to the paparazzi...he wants his privacy At least someone in that family is normal. Covid in Scotland: Sharp rise in cases as deaths also increaseLast week, 52 deaths were linked to Covid while one in 35 people were thought to have the infection. For some wolves, a black coat isn’t just fashionable—it’s a lifesaverBlack wolves can better fight off certain diseases and so are preferred mates for gray wolves, according to a new study. 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ELIZABETHTOWN, Ky.1 / 3 Copyright 2022 The Associated Press.Gene Fischer think of her level of fame? She revealed how her 3-year-old really feels about her life as a comedy star while attending the season five premiere of her show Inside Amy Schumer in New York on Oct.Image source, Getty Images There was a sharp rise in the number of Covid infections in Scotland in the past week, official figures show. (AP) — When Chastity Murry had her first psychotic break, she went into her bathroom and downed a whole bottle of pills, hoping to die. Her teenage daughter had to perform CPR to save her life. Dante Murry, left, and his wife, Chastity Murry, in their home in Elizabethtown, Ky. Around that same time more than a decade ago, the man who would become her husband, Dante Murry, also lost touch with reality and considered suicide. "He's not impressed that there's a microphone and a camera. Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated. Scientists at the Broad Institute of Harvard and MIT identified a particular gene called AKAP11 that's strongly linked to mental disorders, and the Murrys, who both have the disorder depend upon one another to deal with it day-to-day. But a growing body of research shows that bipolar disorder, schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings as well as overlapping symptoms and signs. Despite the increase in Scotland, ONS deputy director of the survey, Sarah Crofts, said the trend of infections was still "uncertain". "They can be considered as part of a spectrum," said Dr. Easley) ELIZABETHTOWN, Ky. "It's such a community on set," she continued. Morgan Sheng, who co-directs a psychiatric research center at the Broad Institute of MIT and Harvard. People are also reading… Bipolar disorder is known for causing extreme mood swings. Her teenage daughter had to perform CPR to save her life. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. So we made it a very child-friendly environment. Schizoaffective disorder includes symptoms of both. Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated. "It is too early to say from the data whether overall recent rises are starting to slow, but we will continue to monitor the data closely. The theory that they exist on a continuum has gained ground as more and more studies have found that variations in some of the same genes influence how susceptible people are to these conditions. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. "They can be considered as part of a spectrum,” said Dr. Needless to say, Amy is thrilled about the revival. Experts say these insights will help doctors better understand what drives the illnesses, how they affect the body's most notoriously bewildering organ and what more can be done to help people. Down the road, experts envision the research could help guide treatment and lead to better drugs. Bipolar disorder is known for causing extreme mood swings. For now, they hope it reinforces the idea that such disorders are biologically rooted and not moral failings or mysterious, unknowable conditions. "Coming back together and writing this season of our show was just such a dream. "That's what the science is giving us – a clear indication that there are genetic markers and risk factors," said Dr. Schizoaffective disorder includes symptoms of both. Ken Duckworth, chief medical officer for the National Alliance on Mental Illness. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. I think I was thinking, you know, 'OK, you're supposed to do the next thing. With they help of doctors and one another, they are keeping their disorders in check and have found purpose helping others in similar straits. Chastity Murry, 48, called them perfect partners;"He's the peanut butter; I'm the jelly. Down the road, experts envision the research could help guide treatment and lead to better drugs. " "Yes," Dante Murry, 50, added with a smile. You're hopefully my last."She's sweeter than I am. “That’s what the science is giving us – a clear indication that there are genetic markers and risk factors,” said Dr." PASSING DOWN PUZZLING CONDITIONSMental illness runs in both of their families – haunting hers for at least five generations, she says. Knowing this"helped me to understand why this is happening to me," Chastity Murry said. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know."That possibility was always there. " Sheng said genetics plays a big part in bipolar disorder, schizoaffective disorder and schizophrenia. Chastity Murry, 48, called them perfect partners; “He’s the peanut butter; I’m the jelly. But experience and environment also play a big part, and these things interact in subtle ways. So it's not like everyone with risk genes is destined to become ill. “She’s sweeter than I am. Morgan said a severe risk gene for schizophrenia, for example, may increase the chance of getting the disease 10-fold. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. Knowing this “helped me to understand why this is happening to me,” Chastity Murry said. Given those odds, parents with the gene might not have any children with the illness. But"if you take a whole extended family that has that risk gene, there will be a number of cases popping up," Morgan said.” Sheng said genetics plays a big part in bipolar disorder, schizoaffective disorder and schizophrenia."It's a roll of the dice." Experts say other illnesses along what some call the"psychosis continuum" are also more likely. So it’s not like everyone with risk genes is destined to become ill."When you look at a family, if you have one person with schizophrenia, you're more likely to have schizophrenia yourself, but you're also more likely to have bipolar," said Dr. Fernando Goes, a psychiatrist at Johns Hopkins University. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. The same is true for schizoaffective disorder, studies show. There are no tests for these conditions — which together affect around 9 million U. But “if you take a whole extended family that has that risk gene, there will be a number of cases popping up,” Morgan said.S. adults — so diagnosis is based on history and the sometimes overlapping symptoms.” Experts say other illnesses along what some call the “psychosis continuum” are also more likely. For instance, psychosis can happen in all three illnesses. This can make diagnosis difficult. Fernando Goes, a psychiatrist at Johns Hopkins University. Sally Littlefield of Oakland, California, was diagnosed with bipolar disorder, then schizoaffective disorder, after spiraling into psychosis during a work meeting in 2018. For 10 months, she was convinced a team of psychologists had assumed control of her life and were experimenting on her against her will. There are no tests for these conditions — which together affect around 9 million U. At one point during a manic episode, Littlefield wandered the streets of San Francisco, breaking into houses and cars, shoplifting and jumping from one car rooftop to another. She was eventually tackled by police and hospitalized. adults — so diagnosis is based on history and the sometimes overlapping symptoms. She came to realize she was ill when her delusions got so grandiose she believed she was president of the United States. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which"prevents a lot of us from recovering. This can make diagnosis difficult." A 'VERY LONG JOURNEY'People with mental illness hope stigma fades as doctors learn more about how these disorders arise and affect the brain. A 2019 study said a growing number of experts now recognize that schizophrenia, schizoaffective disorder and bipolar not only share common genetic risk factors and symptoms but also look similar in neuroimaging and may have common treatment regimens. For 10 months, she was convinced a team of psychologists had assumed control of her life and were experimenting on her against her will. The mood stabilizer lithium, for example, is often used to treat bipolar and schizoaffective disorder. The recent Broad Institute research may provide clues to how the drug works, since AKAP11 interacts with what's thought to be lithium's target. She was eventually tackled by police and hospitalized. Other drugs also treat more than one of the illnesses. The Murrys take several of the same medications. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which “prevents a lot of us from recovering. Someday, experts said genetic insights might allow doctors to intervene earlier in the disease process. While few people get genetic testing now – except perhaps to see how they might react to a particular drug – scientists said that could change in the future. A 2019 study said a growing number of experts now recognize that schizophrenia, schizoaffective disorder and bipolar not only share common genetic risk factors and symptoms but also look similar in neuroimaging and may have common treatment regimens. If people knew their genetic risk and family history, Sheng said, they could seek help if something didn't seem quite right, before an illness caused major problems. Some scientists, while acknowledging common genetic underpinnings of bipolar, schizoaffective disorder and schizophrenia, are skeptical about framing them as on a psychosis continuum, particularly if that leads to changing categories doctors use to diagnose people with each disorder. The recent Broad Institute research may provide clues to how the drug works, since AKAP11 interacts with what’s thought to be lithium's target. They say the current criteria are useful in deciding treatment and care. Scientists agree that more research is needed. The Murrys take several of the same medications. Finding new illness risk genes, for instance, is only the first step toward developing new medicines. A Broad"road map" says researchers must also figure out how the genes function, understand disease mechanisms and identify targets for the drugs. While few people get genetic testing now – except perhaps to see how they might react to a particular drug – scientists said that could change in the future. NAMI's Duckworth said it might be"5 to 50 years" before genetic findings translate into changes in clinical practice."It's a very long journey. Some scientists, while acknowledging common genetic underpinnings of bipolar, schizoaffective disorder and schizophrenia, are skeptical about framing them as on a psychosis continuum, particularly if that leads to changing categories doctors use to diagnose people with each disorder." Meanwhile, many people living with mental illness rely on peer support in addition to medication and psychotherapy. The Murrys check on each other daily. Scientists agree that more research is needed. "I can always tell when he's having a bad day. He can always tell when I'm having a bad day," said Chastity Murry, who has also been diagnosed with borderline personality disorder and an anxiety disorder. A Broad “road map” says researchers must also figure out how the genes function, understand disease mechanisms and identify targets for the drugs."If I'm acting a little off or something, he'll ask me: Have you taken your meds today? But I don't get offended because I know he's got my best interest in mind." Both have also learned and grown from working as volunteers. “It’s a very long journey. Together, they facilitate support groups twice a week, check in with peers regularly by phone, and have been trained to help people who are suicidal. "This is my path in life, and his path as well," Chastity Murry said. The Murrys check on each other daily."We're helping them, but they're also helping us." ___ 10 reasons online mental health therapy has grown over the last decade 10 reasons online mental health therapy has grown over the last decade COVID-19 spurred the need for therapy to go remote COVID-19 also worsened mental health for many Mental illness rates have increased in the last decade Demand has increased for mental health treatment There is less stigma around mental health Online mental health care can be more convenient Online health services are growing Insurers are offering expanded coverage for telehealth Video conferencing has become more mainstream Internet connectivity has improved, particularly in rural areas The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. He can always tell when I’m having a bad day,” said Chastity Murry, who has also been diagnosed with borderline personality disorder and an anxiety disorder. The AP is solely responsible for all content. Tags Respond: Write a letter to the editor Write a guest opinion Subscribe to stay connected to Tucson.” Both have also learned and grown from working as volunteers. A subscription helps you access more of the local stories that keep you connected to the community. Build your health & fitness knowledge Sign up here to get the latest health & fitness updates in your inbox every week! . “This is my path in life, and his path as well,” Chastity Murry said.