Publications - Lawrenson Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Lawrenson Lab Back to Lawrenson Lab Lab Members Publications Research Areas Publications See a complete PubMed list of publications by Kate Lawrenson, PhD. Selected Key Publications Gusev A*, Lawrenson K*, Lin X, Lyra PC, Kar S, Vavra KC, Segato F, Fonseca MAS, Lee JM, Pejovic T, Ovarian Cancer Association Consortium, et al. Multi-tissue transcriptome-wide association study identifies 26 novel candidate susceptibility genes for high grade serous epithelial ovarian cancer [published online ahead of print May 25, 2018]. https://www.biorxiv.org/content/10.1101/330613v1. Prendergast EN, de Souza Fonseca MA, Dezem FS, Lester J, Karlan BY, Noushmehr H, Lin X, Lawrenson K. Optimizing exosomal RNA isolation for RNA-Seq analyses of archival sera specimens. PLOS One. 2018 May 8;13(5):e0196913. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0196913. Adler EK, Corona RI, Lee JM, Rodriguez-Malave N, Mhawech-Fauceglia P, Sowter H, Hazelett DJ, Lawrenson K, Gayther SA. The PAX8 cistrome in epithelial ovarian cancer. Oncotarget. 2017 Nov 27;8(65):108316-108332. http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=22718. Phelan CM, Kuchenbaecker KB, Tyrer JP, Kar SP, Lawrenson K, Winham SJ, Dennis J, Pirie A, Riggan MJ, Chornokur G, et al. Identification of 12 new susceptibility loci for different histotypes of epithelial ovarian cancer. Nat Genet. 2017 May;49(5):680-691. https://www.nature.com/articles/ng.3826. Kar SP, Adler E, Tyrer J, Hazelett D, Anton-Culver H, Bandera EV, Beckmann MW, Berchuck A, Bogdanova N, Brinton L, Butzow R, Campbell I, Carty K, Chang-Claude J, Cook LS, Cramer DW, Cunningham JM, Dansonka-Mieszkowska A, Doherty JA, Dörk T, Dürst M, Eccles D, Fasching PA, Flanagan J, Gentry-Maharaj A, Glasspool R, Goode EL, Goodman MT, Gronwald J, Heitz F, Hildebrandt MA, Høgdall E, Høgdall CK, Huntsman DG, Jensen A, Karlan BY, Kelemen LE, Kiemeney LA, Kjaer SK, Kupryjanczyk J, Lambrechts D, Levine DA, Li Q, Lissowska J, Lu KH, Lubiński J, Massuger LF, McGuire V, McNeish I, Menon U, Modugno F, Monteiro AN, Moysich KB, Ness RB, Nevanlinna H, Paul J, Pearce CL, Pejovic T, Permuth JB, Phelan C, Pike MC, Poole EM, Ramus SJ, Risch HA, Rossing MA, Salvesen HB, Schildkraut JM, Sellers TA, Sherman M, Siddiqui N, Sieh W, Song H, Southey M, Terry KL, Tworoger SS, Walsh C, Wentzensen N, Whittemore AS, Wu AH, Yang H, Zheng W, Ziogas A, Freedman ML, Gayther SA, Pharoah PD, Lawrenson K. Enrichment of putative PAX8 target genes at serous epithelial ovarian cancer susceptibility loci. Br J Cancer. 2017 Feb 14;116(4):524-535. https://www.nature.com/articles/bjc2016426. Keleman LE, Lawrenson K, Tyrer J, Li Q, Lee JM, Seo JH, Phelan CM, Beesley J, Chen X, Spindler TJ, et al. Genome-wide significant risk associations for mucinous ovarian carcinoma. Nat Genet. 2015;47(8):888-897. http://www.nature.com/ng/journal/v47/n8/abs/ng.3336.html. Lawrenson K, Li Q, Kar S, Seo JH, Tyrer J, Spindler TJ, Lee J, Chen Y, Karst A, Drapkin R, et al. Cis-eQTL analysis and functional validation of candidate susceptibility genes for high-grade serous ovarian cancer. Nat Commun. 2015 Sep 22;6:8234. http://www.nature.com/ncomms/2015/150922/ncomms9234/full/ncomms9234.html. Coetzee SG, Shen HC, Hazelett DJ, Lawrenson K, Kuchenbaecker K, Tyrer J, Rhie SK, Levanon K, Karst A, Drapkin R, et al. Cell-type-specific enrichment of risk-associated regulatory elements at ovarian cancer susceptibility loci. Hum Mol Genet. 2015;24(13):3595-3607. https://academic.oup.com/hmg/article/24/13/3595/610448 Lawrenson K, Mhawech-Fauceglia P, Worthington J, Spindler TJ, O’Brien D, Lee JM, Spain, G, Wang G, Darcy KM, Pejovic T, et al. Identification of novel candidate biomarkers of epithelial ovarian cancer by profiling the secretomes of three-dimensional genetic models of ovarian carcinogenesis. Int J Cancer. 2015;137(8):1806-1817. http://onlinelibrary.wiley.com/doi/10.1002/ijc.29197/abstract. Lawrenson K, Sproul D, Grun B, Notaridou M, Benjamin E, Jacobs IJ, Dafou D, Sims AH, Gayther SA. Modelling genetic and clinical heterogeneity in epithelial ovarian cancers. Carcinogenesis. 2011;32(10):1540-1549. https://academic.oup.com/carcin/article/32/10/1540/2463652 Lee JM, Mhawech-Fauceglia P, Lee N, Parsanian LC, Lin YG, Gayther SA, Lawrenson K. A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro. Lab Invest. 2013;93(5):528-542. http://www.nature.com/labinvest/journal/v93/n5/full/labinvest201341a.html. Lawrenson K, Lee N, Torres H, Lee JM, Brueggmann D, Rao PN, Noushmehr H, Gayther SA. Src as a novel therapeutic target for endometriosis. Gynecol Oncol. 2014;135(1):100-107. http://www.gynecologiconcology-online.net/article/S0090-8258(14)01056-7/abstract. Lawrenson K, Grun B, Lee N, Mhawech-Fauceglia P, Kan J, Swenson S, Lin YG, Pejovic T, Millstein J, Gayther SA. NPPB is a novel candidate biomarker expressed by cancer-associated fibroblasts in epithelial ovarian cancer. Int J Cancer. 2015;136(6):1390-1401. http://onlinelibrary.wiley.com/doi/10.1002/ijc.29092/abstract. Adler E, Mhawech-Fauceglia P, Gayther SA, Lawrenson K. PAX8 expression in normal ovaries. Hum Pathol. 2015;46(7):948-956. http://www.humanpathol.com/article/S0046-8177(15)00121-5/abstract. Kar SP, Tyrer JP, Li Q, Lawrenson K, Aben KK, Anton-Culver H, Antonenkova N, Chenevix-Trench G; Australian Cancer Study; Australian Ovarian Cancer Study Group, et al. Network-based integration of GWAS and gene expression identifies a HOX-centric network associated with serous ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2015 Jul 24. https://aacrjournals.org/cebp/article/24/10/1574/70485/Network-Based-Integration-of-GWAS-and-Gene Contact the Lawrenson Lab 8700 Beverly Blvd. Davis Building, Third Floor Los Angeles, CA 90048 310-423-7935 Send a Message Please ensure Javascript is enabled for purposes of website accessibility