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Watson, PharmD — By Jen Seabright, PharmD on April 7, 2022 OverviewZomig (zolmitriptan) is a prescription brand-name medication. The Food and Drug Administration (FDA) has approved it to treat migraine with or without aura. Zomig comes as a tablet that you swallow, a tablet that dissolves on your tongue, and a nasal spray. Zomig tablets and orally disintegrating tablets (Zomig ZMT) are approved for use in adults. Zomig nasal spray is approved for use in adults and children ages 12 years and older. Zomig belongs to a drug class called triptans. These drugs bind to certain serotonin receptors in the brain to reduce swelling and block pain. All three forms of Zomig come in a generic form called zolmitriptan. Dosage summary The following chart summarizes Zomig’s dosage. Milligrams is abbreviated as mg. Your doctor will determine the dosage that’s best for you.Zomig formTypical starting doseMaximum single doseMaximum daily dosetablet1.25 mg or 2.5 mg5 mg10 mgorally disintegrating tablet1.25 mg or 2.5 mg5 mg10 mgnasal spray2.5 mg5 mg10 mg For information about the dosage of Zomig, including its strengths and how to take the drug, keep reading. For a comprehensive look at Zomig, see this article. This article describes typical dosages for Zomig provided by the drug’s manufacturer. When taking Zomig, always follow the dosage instructions prescribed by your doctor. Zomig dosage Below is important information about Zomig dosage for its approved uses. Zomig forms Zomig comes in three forms:a tablet that you swallowan orally disintegrating tablet (Zomig ZMT)a nasal spray Zomig strengths Zomig comes in two strengths: 2.5 milligrams (mg) and 5 mg. Typical dosages Typically, your doctor will start you on a low dosage. Then they’ll adjust it over time to reach the amount that’s right for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. Dosage for migraine Zomig’s starting tablet dosage is 1.25 mg or 2.5 mg. If your doctor recommends a 1.25-mg dose, you’ll split a 2.5-mg Zomig tablet in half. However, the Zomig orally disintegrating tablet (Zomig ZMT) should be taken whole. You should not split this tablet in half. (If your dosage is 1.25 mg, your doctor will likely not prescribe Zomig ZMT). For Zomig nasal spray, the starting dose for migraine is 2.5 mg. There’s only one dose of 2.5 mg in each nasal sprayer. Zomig is typically taken at the first sign of a migraine attack. A second dose of Zomig may be taken 2 hours after the first dose if your migraine doesn’t improve or starts to improve but comes back. The maximum dose of Zomig taken at one time is 5 mg. The maximum daily dose of Zomig is 10 mg over a 24-hour period. Children s dosage Zomig nasal spray is the only form of Zomig approved for use in children ages 12 years and older. The typical starting dose is 2.5 mg. A second dose of Zomig may be taken 2 hours after the first dose if your child’s migraine does not improve or starts to improve but comes back. The maximum dose of Zomig that your child’s doctor will prescribe is 5 mg per dose. The maximum daily dose for children is 10 mg. Long-term treatment Zomig is meant to be used as a long-term treatment. If you and your doctor determine that Zomig is safe and effective for you, you’ll likely take it long term. Keep in mind that Zomig is not meant to be used every day. It isn’t known if Zomig tablets are safe to use for treating more than three migraine episodes within a 30-day period. And it isn’t known if Zomig nasal spray is safe to use for treating more than four migraine episodes within a 30-day period. If you need to use Zomig more often than is recommended, talk with your doctor. They may suggest a different treatment for your migraine episodes. Factors that can affect your dosage The Zomig dosage your doctor prescribes will depend on several factors. These include:the severity of the condition you’re using Zomig to treatthe form of Zomig you takeyour ageother medications you may take Other medical conditions you have can also affect your Zomig dosage. How to Take Zomig Zomig comes in three forms. Below is information about how to take each form. Zomig can be taken with or without food. Zomig tablets are tablets that you swallow. If your dosage is 1.25 mg, you’ll split a 2.5 mg tablet in half. Zomig ZMT is an orally disintegrating tablet that dissolves on your tongue. Be sure to keep Zomig ZMT in its sealed packaging until you’re ready to take your dose. Zomig ZMT tablets should not be broken in half. For Zomig nasal spray, you’ll spray the medication into one nostril. Each bottle of Zomig nasal spray contains one dose of 2.5 mg. Here are some instructions on how to use the nasal spray.Accessible drug labels and containers If you’re having trouble reading your prescription label, talk with your doctor or pharmacist. Some pharmacies offer labels with large print, braille, or a code you scan with a smartphone to convert text to speech. If your local pharmacy doesn’t have these options, your doctor or pharmacist might be able to recommend a pharmacy that does. If you’re having trouble opening medication bottles, ask your pharmacist about putting Zomig in an easy-open container. They also may recommend tools that can make it easier to open bottles. Zomig and overdose It’s important that you don’t use more Zomig than your doctor prescribes. For some medications, taking more than the recommended amount may lead to side effects or overdose. If you take more than the recommended amount of Zomig Call your doctor right away if you believe you’ve taken too much Zomig. Another option is to call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room. Takeaway and helpful resources The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Zomig for you, they will prescribe the dosage that’s right for you. Always follow the dosage that your doctor prescribes for you. As with any drug, never change your dosage of Zomig without your doctor’s recommendation. If you have questions about the dosage of Zomig that’s right for you, talk with your doctor. Besides learning about dosage, you may want other information about Zomig. These additional articles might be helpful to you:More about Zomig. For information about other aspects of Zomig, refer to this article.Details about migraine. For details about migraine, see our headache and migraine hub and these related articles. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. 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