Triptodur Side Effects What They Are and How to Manage Them
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frontiersin.org/articles/10.3389/fped.2022.816635/fullPseudotumor cerebri. (2022).
ninds.nih.gov/health-information/disorders/pseudotumor-cerebriSupprelin LA (histrelin acetate) subcutaneous implant. (2022).
endodocuments.com/SUPPRELIN-LA/PITriptodur (triptorelin) for extended-release injectable suspension, for intramuscular use. (2022).
accessdata.fda.gov/drugsatfda_docs/label/2022/208956s010lbl.pdfOur experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Oct 16, 2022 By Jessica Caporuscio, PharmD Edited By Steven O'Brien Medically Reviewed By Damilola Omopariola, PharmD, BCACP Share this articleMedically reviewed by Damilola Omopariola, PharmD, BCACP — By Jessica Caporuscio, Pharm.D. on October 16, 2022
Side Effects of Triptodur What You Need to Know
Medically reviewed by Damilola Omopariola, PharmD, BCACP — By Jessica Caporuscio, Pharm.D. on October 16, 2022Introduction
If your child has central precocious puberty (CPP), their doctor might suggest Triptodur as a treatment option. Triptodur is a prescription drug used to treat CPP in some children. CPP causes early puberty. Depending on your child’s condition, they may receive Triptodur long term. The active ingredient in Triptodur is triptorelin. (An active ingredient is what makes a drug work.) It comes as a powder that a healthcare professional mixes with liquid to form a suspension. They’ll then give the suspension to your child as an injection into a muscle. For more information about Triptodur, including details about its uses, see this in-depth article. Like other drugs, Triptodur can cause mild to serious side effects. Keep reading to learn more.What are the more common side effects of Triptodur
Some children may experience mild to serious side effects during their Triptodur treatment. A few examples of Triptodur’s commonly reported side effects include:injection site reactions, such as pain and itchinessinfections, such as ear, sinus, and stomach infectionsheadachecoughworsening symptoms of puberty* * To learn more about this side effect, see the “Side effects explained” section below.What are the mild side effects of Triptodur
Examples of mild side effects that have been reported with Triptodur include:injection site reactions, such as pain and itchinesshot flashesheadachecoughinfections, such as ear, sinus, and stomach infectionsworsening symptoms of puberty*mild allergic reaction* * To learn more about this side effect, see the “Side effects explained” section below. In most cases, these side effects should be temporary. And some may be easily managed. But if your child has any symptoms that are ongoing or bothersome, talk with your child’s doctor or pharmacist. And do not stop Triptodur treatment unless your child’s doctor recommends it. Triptodur may cause mild side effects other than the ones listed above. See the drug’s prescribing information for details. Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect your child has had with Triptodur, visit MedWatch.What are the serious side effects of Triptodur
It’s possible to have serious side effects with Triptodur. Serious side effects of Triptodur are listed below. Many of these weren’t reported in studies of the drug. Instead, they were reported after the drug became available on the market. It’s unclear how often these side effects happened or whether Triptodur was the cause. Serious side effects that Triptodur may cause include:depression, which in rare cases may be accompanied by suicidal thoughts and behaviorsconvulsions, which are a kind of seizureanxiety and other mental health problems*changes in mood*pseudotumor cerebri*severe allergic reaction* * To learn more about this side effect, see the “Side effects explained” section below. If your child develops serious side effects while receiving Triptodur, call their doctor right away. If the side effects seem life threatening or you think your child is having a medical emergency, immediately call 911 or your local emergency number.Help is out there
If you or someone you know is in crisis and considering suicide or self-harm, please seek support:Call the 988 Suicide and Crisis Lifeline at 988.Text HOME to the Crisis Textline at 741741. Not in the United States? Find a helpline in your country with Befrienders Worldwide.Call 911 or your local emergency services number if you feel safe to do so. If you’re calling on behalf of someone else, stay with them until help arrives. You may remove weapons or substances that can cause harm if you can do so safely. If you are not in the same household, stay on the phone with them until help arrives.FAQs about Triptodur s side effects
Get answers to some frequently asked questions about Triptodur’s side effects.Does Triptodur cause any long-term side effects
Studies of Triptodur didn’t report long-term side effects. Reported side effects usually lasted for a few weeks after starting treatment. Some children may have certain side effects after each dose of Triptodur. This happens because specific hormone levels rise quickly after receiving a dose. After a few weeks, hormone levels should drop, and side effects should disappear. Studies didn’t report any side effects occurring after stopping Triptodur. But since the drug is used to delay puberty, once the treatment ends, puberty will likely start again for your child. If you’re concerned about Triptodur causing long-term side effects, talk with your child’s doctor. They can recommend ways to manage side effects of Triptodur that your child may develop. Depending on the severity and type of side effect your child has, your child’s doctor may stop prescribing Triptodur.Can Triptodur cause weight gain
No, weight gain wasn’t a reported side effect of Triptodur in studies. But other drugs similar to Triptodur can cause weight gain. For example, Supprelin LA is another medication that doctors prescribe for central precocious puberty. Unlike Triptodur, it can cause weight gain. In a study, researchers reported weight gain in females* taking drugs similar to Triptodur. But weight gain stopped after a year. If you have concerns about Triptodur and weight gain, talk with your child’s doctor or pharmacist. * In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.Side effects explained
Learn more about some of the side effects Triptodur may cause.Anxiety and other mental health problems
Children may develop mild or severe anxiety when receiving Triptodur. Symptoms of anxiety include:nervousnessfeeling worriedinsomnia (trouble sleeping)restlessnessrapid heart raterapid breathing If your child has other mental health problems, symptoms of their condition may worsen during Triptodur treatment. Examples of these symptoms include:cryingirritabilityrestlessnessangeraggressive behaviorWhat might help
If your child has anxiety or other mental health problems, tell their doctor before starting Triptodur treatment. They can let you know whether Triptodur is safe for your child to receive. If you notice your child having any new or worsening symptoms of anxiety or other mental health problems, tell your child’s doctor right away. During follow-up appointments, they’ll check for changes in your child’s mental state. Depending on the severity of your child’s condition, their doctor may change their treatment. For information about how to recognize anxiety in a child and treatments for this condition, see this article.Changes in mood
Changes in mood can occur with Triptodur. Depression and suicidal thoughts and behaviors are rare side effects of Triptodur. If your child has a mood disorder, they may have a higher risk of changes in mood while receiving Triptodur. Symptoms of mood changes include:angeraggressive behaviorirritabilityWhat might help
Tell your child’s doctor if your child has any mood disorders. If your child’s mood changes after starting Triptodur treatment, let their doctor know. They can tell you whether treatment with Triptodur is still safe for your child. Or they may suggest a medication other than Triptodur for treating central precocious puberty. For information about how to recognize depression in a child and treatments for this condition, see this article.Worsening symptoms of puberty
Due to the changes in hormone levels that occur when first starting Triptodur treatment, your child’s symptoms of puberty may worsen. For example, females* may have more vaginal bleeding. In studies of Triptodur, this was a commonly reported side effect. After each dose of Triptodur, your child may experience worsening symptoms of puberty. * In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.What might help
Worsening symptoms of puberty that may occur when starting Triptodur treatment usually resolve on their own over time. Once hormone levels drop a few weeks after the injection, puberty symptoms should disappear. But if your child’s symptoms continue beyond 2 months after receiving a dose of Triptodur, contact your child’s doctor.Pseudotumor cerebri
Triptodur and similar drugs can cause a severe side effect called pseudotumor cerebri. Pseudotumor cerebri is a condition that has the same symptoms as a brain tumor but without the tumor. Symptoms of pseudotumor cerebri include:headachenausea or vomitingpulsing sounds in the head or ringing in the earsvision problems, such as blurry vision, double vision, or loss of visionpain behind the eye or pain with eye movementdizziness These symptoms are likely due to increased pressure inside the brain.What might help
If your child has any symptoms of pseudotumor cerebri, make sure to tell their doctor. During follow-up appointments, your child’s doctor will check your child for signs and symptoms of this condition. If your child has pseudotumor cerebri, their doctor will likely recommend stopping Triptodur treatment.Allergic reaction
Like most drugs, Triptodur can cause an allergic reaction in some children. Symptoms can be mild to serious and can include:skin rashhivesitchinessflushing (temporary warmth, redness, or deepening of skin color)swelling under the skin, usually in the eyelids, lips, hands, or feetswelling of the mouth, tongue, or throat, which can make it hard to breathe Symptoms of a severe allergic reaction to Triptodur can include:fast heart ratesweatingdizzinessfaintingWhat might help
If your child has mild symptoms of an allergic reaction, such as a mild rash, call your child’s doctor right away. They may suggest a treatment to manage your child’s symptoms. Examples include:an antihistamine your child takes by mouth, such as Benadryl (diphenhydramine)a product you or your child applies to their skin, such as hydrocortisone cream If your child’s doctor confirms that your child has had a mild allergic reaction to Triptodur, they’ll decide whether your child should continue receiving it. If your child has symptoms of a severe allergic reaction, such as swelling or trouble breathing, call 911 or your local emergency number right away. These symptoms could be life threatening and require immediate medical care. If your child’s doctor confirms that your child has had a serious allergic reaction to Triptodur, they may suggest a different treatment instead of Triptodur.Keeping track of side effects During your child’s Triptodur treatment, consider taking notes on any side effects they’re having. You can then share this information with their doctor. This is especially helpful when your child first starts taking new drugs or using a combination of treatments. Your side effect notes can include things such as:what dose of the drug your child was taking when they had the side effecthow soon your child had the side effect after starting that dosewhat your child’s symptoms werehow it affected your child’s daily activitieswhat other medications your child was takingany other information you feel is important Keeping notes and sharing them with your child’s doctor will help them learn more about how Triptodur affects your child. They can then use this information to adjust your child’s treatment plan if needed.Warnings for Triptodur
Triptodur may not be right for your child if they have certain medical conditions. (This is known as a drug-condition interaction.) Other factors may also affect whether Triptodur is a good treatment option for your child. Discuss your child’s health history with their doctor before they start Triptodur treatment. Factors to consider include those described below. Mental health problems. Children taking drugs such as Triptodur may develop mental health problems, such as depression, anxiety, or changes in mood. If your child already has mental health problems, Triptodur may make them worse. Your child’s doctor will monitor them for any worsening mental health symptoms. Allergic reaction. If your child has had an allergic reaction to Triptodur or any of its ingredients, their doctor will likely not prescribe it for them. Ask them about other medications that might be better options for your child. Convulsions. Children who have seizure disorders such as epilepsy may have a higher risk of convulsions with Triptodur. Certain conditions of the brain, such as brain tumors, can also increase the risk of convulsions in children receiving Triptodur. If your child has a seizure disorder or brain condition, tell their doctor. This will help them determine whether Triptodur is safe for your child. Liver or kidney problems. In adults with liver or kidney problems, Triptodur can build up in the blood. This can increase the risk of side effects. It is not clear whether this same effect can occur in children. If your child has a history of liver or kidney problems, talk with their doctor before they start Triptodur treatment. The doctor will discuss with you whether Triptodur is a good treatment option for your child.Alcohol and Triptodur
While some medications interact with alcohol, Triptodur isn’t one of them. But if your child takes medications or uses products that contain alcohol, talk with their doctor or pharmacist. They can tell you whether your child can still use these products safely with Triptodur.Pregnancy and breastfeeding while receiving Triptodur
Triptodur is not safe to receive during pregnancy. The rise in hormones that occurs with Triptodur can increase the risk of miscarriage. If your child becomes pregnant while receiving Triptodur, contact their doctor right away. It’s uncertain whether Triptodur can pass into breast milk or what effect it might have on children breastfed by someone taking the drug. If your child is breastfeeding or planning to do so, talk with their doctor about the risks and benefits of taking Triptodur during this time.What to ask your doctor
Mild side effects of Triptodur are common. But these usually only last for a few weeks after starting treatment. Some children may have short-term side effects after every dose. For additional information about Triptodur’s side effects, talk with your child’s doctor or pharmacist. Here are a few questions you may want to ask:If my child has a headache after a Triptodur injection, how will I know whether they may have pseudotumor cerebri?How can I prevent my child from getting infections while receiving Triptodur?How does Triptodur affect my child’s chances of getting pregnant in the future?How will Triptodur treatment affect my child’s growth? To get information on different conditions and tips for improving your health, subscribe to any of Healthline’s newsletters. You may also want to check out the online communities at Bezzy. It’s a place where people with certain conditions can find support and connect with others. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Last medically reviewed on October 16, 2022How we vetted this article
SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Leite AL, et al. (2022). Do GnRH agonists really increase body weight gain? Evaluation of a multicentric Portuguese cohort of patients with central precocious puberty.frontiersin.org/articles/10.3389/fped.2022.816635/fullPseudotumor cerebri. (2022).
ninds.nih.gov/health-information/disorders/pseudotumor-cerebriSupprelin LA (histrelin acetate) subcutaneous implant. (2022).
endodocuments.com/SUPPRELIN-LA/PITriptodur (triptorelin) for extended-release injectable suspension, for intramuscular use. (2022).
accessdata.fda.gov/drugsatfda_docs/label/2022/208956s010lbl.pdfOur experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Oct 16, 2022 By Jessica Caporuscio, PharmD Edited By Steven O'Brien Medically Reviewed By Damilola Omopariola, PharmD, BCACP Share this articleMedically reviewed by Damilola Omopariola, PharmD, BCACP — By Jessica Caporuscio, Pharm.D. on October 16, 2022