New Findings on Rare Mucinous Ovarian Cancer May Change Tx Ovarian Cancer HEAD TOPICS

New Findings on Rare Mucinous Ovarian Cancer May Change Tx

10/23/2022 9:20:00 AM

A global study of the microscopic patterns of cell growth in samples taken from women with this rare form of ovarian cancer may lead to treatment changes for some

Ovarian Cancer Malignant Ovarian Neoplasm

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Medscape

The largest study to date of mucinous ovarian cancer offers hope for a more personalized treatment approach in patients diagnosed early with this rare form of the disease. A global study of the microscopic patterns of cell growth in samples taken from women with this rare form of ovarian cancer may lead to treatment changes for some and differs from the more common, high-grade serous form of epithelial ovarian cancer in that it is usually symptomatic with large tumors. This leads to early diagnosis, often in women under 40 years old.Clinical Cancer Research,“We’ve shown for the first time that women who have early stage disease — meaning they have tumors that haven't spread beyond the ovary — have much poorer survival chances in the first 2 years from diagnosis if they have what we call an infiltrative pattern of invasion,” explained first author Nicola S. Meagher, a research fellow and PhD candidate at the University of New South Wales Sydney (UNSW), Sydney, Australia, said in a Read more:
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A beloved educator and civil rights advocate in the Hempstead community is leading the 134th annual Homecoming Parade as grand marshal. Read more >> 1 in 3 teens reported poor mental health during pandemic, study findsMore than 1 in 3 high school teens dealt with poor mental health during the pandemic, and 1 in 5 reported considering suicide, according to a new study from the CDC. GOPnazis voted AGAINST mental health in schools. Remind me of this study next time someone advocates for home schooling. Apparently spending to much time with your family is bad for your brain. =) 1 in 5?!?! That is a serious number!!! The Mountain in the Sea review: A remarkable study of consciousnessWhat is consciousness, and why do we simultaneously seek it out and dread it in other entities? 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The EU is closer to acceptance of Web3 than these👇swithering tortoises in BrexitBritain at least A study questioning colonoscopy screening’s benefits has big caveatsThe study included a lot of people who were invited to get the procedure but didn’t. That’s one limitation of several. (MOC) offers hope for a more personalized treatment approach in patients diagnosed early with this rare form of the disease.suicidal behaviors .What is consciousness, and why do we simultaneously seek it out and dread it in other entities? Ray Nayler’s staggering novel has grand ambitions and even provides a few answers, finds Sally Adee.As part of the Reichsfilmintendanz, the division set up by Hitler’s propaganda minister Joseph Goebbels to promote the Nazi’s racist and antisemitic agenda, Bauer approved such films as Veit Harlan’s Kolberg (1945), a war drama meant to encourage the German population to fight the Allies to the last man. MOC accounts for only about 3% of cases, and differs from the more common, high-grade serous form of epithelial ovarian cancer in that it is usually symptomatic with large tumors. This leads to early diagnosis, often in women under 40 years old. STOCK/Getty Images A woman sobs in this stock photo. The new study involved more than 100 researchers from across the globe working together to analyze microscopic patterns of cell growth in 604 tissue samples from patients with stage I MOC, the largest such series to date.   The findings were published online Oct. Meanwhile, students who reported experiencing four or more of these negative experiences were 25 times more likely to report a suicide attempt. 12, 2022, in  Clinical Cancer Research, a journal of the American Association for Cancer Research.  “In light of the new findings, the Berlinale management asked itself how the view of the founding years of the Berlinale has been altered as a result, but also whether Bauer’s Nazi involvement had an impact on the design of the festival,” the Berlinale said in a statement Friday. The results show that an infiltrative pattern of invasion, as opposed to an expansile pattern, was associated with decreased overall survival (OS) within 2 years after diagnosis (hazard ratio, 2. MORE: After daughter's suicide, dad shares emotional message to 'help at least one person' "With COVID-related threats to health, events in the news, and the accessibility of information online, it's hard to insulate yourself from the stress, and has been even harder to find stability, support and connection -- which is what teens need most at this stage of their lives," said Dr.77). “We’ve shown for the first time that women who have early stage disease — meaning they have tumors that haven't spread beyond the ovary — have much poorer survival chances in the first 2 years from diagnosis if they have what we call an infiltrative pattern of invasion,” explained first author Nicola S. Because suicide has been the second-most common cause of death among those ages 10 to 14, mental health professionals say more research is needed to address the influence the pandemic has had on mental health in this vulnerable population. Meagher, a research fellow and PhD candidate at the University of New South Wales Sydney (UNSW), Sydney, Australia, said in a press release. “Knowing this in the early stage of the disease means we can identify patients who could benefit from additional chemotherapy following surgery to remove their ovaries,” she added.” In a statement, Berlinale festival co-directors Mariette Rissenbeek and Carlo Chatrian said the report shone a new light on the festival’s past. The team also looked at 19 candidate genes and found that high expression of thrombospondin 2 (THBS2) and transgelin (TAGLN) in MOC tumors are markers for poor prognosis. The latter finding may eventually help explain “some of the biology” of the disease and assist in developing targeted drugs, Meagher commented. Need to Align Treatment Guidelines The researchers hope that the results of this study will lead to changes in treatment guidelines. At present, guidelines on how to treat women with early stage MOC differ around the world due to limited data, explained principal investigator Susan Ramus, PhD, a professor at UNSW and head of the Ovarian Tumor Tissue Analysis  consortium. “For example, in some parts of the world, an infiltrative pattern was acknowledged as an important feature and determined what treatment those women receive,” Ramus explained in the press release. “Whereas in others, all patients are recommended for the same pathway of treatment. “We hope that after this large study treatment guidelines can be aligned and that we can target treatment for women who may have these more serious indicators, even if they are diagnosed in early stages.” The investigators are planning a validation study to “further investigate these genomic markers as the basis for a targeted treatment strategy,” she noted. Meagher and Ramus reported no conflicts of interest. Meagher noted that she has received a travel grant from NanoString Technologies unrelated to this work. Clinical Cancer Research Abstract. Sharon Worcester, MA, is an award-winning medical journalist based in Birmingham, Alabama, writing for Medscape, MDedge, and other affiliate sites. She currently covers oncology, but she has also written on a variety of other medical specialties and healthcare topics. She can be reached at .