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Genes link bipolar and schizophrenia once thought unrelated

10/23/2022 1:35:00 AM

A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings

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Dothan Eagle

A growing body of research shows that bipolar disorder , schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings. A growing body of research shows that bipolar disorder , schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings. But a growing body of research shows that bipolar disorder, schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings as well as overlapping symptoms and signs.The theory that they exist on a continuum has gained ground as more and more studies have found that variations in some of the same genes influence how susceptible people are to these conditions. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. Read more:
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Complete coverage of the Fightin’ Phils and their MLB rivals from NBC Sports Philadelphia. Read more >> Genes link bipolar and schizophrenia once thought unrelatedA growing body of research shows that bipolar disorder , schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings. Genes link bipolar, schizophrenia, once thought unrelatedBipolar disorder is known for causing extreme mood swings. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Schizoaffective disorder includes symptoms of both. Amy Schumer Admits Son Gene Is 'Not Impressed' With Her Glam Life - E! OnlineWhat does Amy Schumer's 3-year-old son Gene think about her being famous? Scroll on to hear her answer. He's not used to the paparazzi...he wants his privacy At least someone in that family is normal. Covid in Scotland: Sharp rise in cases as deaths also increaseLast week, 52 deaths were linked to Covid while one in 35 people were thought to have the infection. Ancient DNA reveals rapid natural selection during the Black DeathPlague pandemic might have led to rapid evolution of immune genes. That some live and some die under environmental stress, such as a plague, is the very defination of evolution by natural selection. So, why did they need to look at the DNA to know that? As every stressor in the environment? Bigger stressor bigger adaptation? ELIZABETHTOWN, Ky.ELIZABETHTOWN, Ky.1 / 3 Copyright 2022 The Associated Press.Gene Fischer think of her level of fame? She revealed how her 3-year-old really feels about her life as a comedy star while attending the season five premiere of her show Inside Amy Schumer in New York on Oct. (AP) — When Chastity Murry had her first psychotic break, she went into her bathroom and downed a whole bottle of pills, hoping to die. Her teenage daughter had to perform CPR to save her life. Her teenage daughter had to perform CPR to save her life. Around that same time more than a decade ago, the man who would become her husband, Dante Murry, also lost touch with reality and considered suicide., Thursday, July 7, 2022. Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated. Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated. But a growing body of research shows that bipolar disorder, schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings as well as overlapping symptoms and signs.'" Still, Amy—who shares the child with her husband, chef Chris Fischer —suggested Gene enjoys tagging along when she's at work. "They can be considered as part of a spectrum," said Dr. "They can be considered as part of a spectrum," said Dr. Easley) ELIZABETHTOWN, Ky. Morgan Sheng, who co-directs a psychiatric research center at the Broad Institute of MIT and Harvard. People are also reading… Bipolar disorder is known for causing extreme mood swings. People are also reading… Bipolar disorder is known for causing extreme mood swings. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Around that same time more than a decade ago, the man who would become her husband, Dante Murry, also lost touch with reality and considered suicide. Schizoaffective disorder includes symptoms of both. Schizoaffective disorder includes symptoms of both." Six years after the end of its run on Comedy Central, Inside Amy Schumer is returning to fans' screens and premiering on Paramount+ Oct. The theory that they exist on a continuum has gained ground as more and more studies have found that variations in some of the same genes influence how susceptible people are to these conditions. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. "They can be considered as part of a spectrum,” said Dr. Experts say these insights will help doctors better understand what drives the illnesses, how they affect the body's most notoriously bewildering organ and what more can be done to help people. Down the road, experts envision the research could help guide treatment and lead to better drugs. Down the road, experts envision the research could help guide treatment and lead to better drugs. For now, they hope it reinforces the idea that such disorders are biologically rooted and not moral failings or mysterious, unknowable conditions. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. "Coming back together and writing this season of our show was just such a dream. "That's what the science is giving us – a clear indication that there are genetic markers and risk factors," said Dr. "That's what the science is giving us – a clear indication that there are genetic markers and risk factors," said Dr. Ken Duckworth, chief medical officer for the National Alliance on Mental Illness. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. With they help of doctors and one another, they are keeping their disorders in check and have found purpose helping others in similar straits. Chastity Murry, 48, called them perfect partners;"He's the peanut butter; I'm the jelly. Chastity Murry, 48, called them perfect partners;"He's the peanut butter; I'm the jelly." To her husband, Amy added, "Not that that is true, Chris. " "Yes," Dante Murry, 50, added with a smile. For now, they hope it reinforces the idea that such disorders are biologically rooted and not moral failings or mysterious, unknowable conditions."She's sweeter than I am."She's sweeter than I am." PASSING DOWN PUZZLING CONDITIONSMental illness runs in both of their families – haunting hers for at least five generations, she says. Knowing this"helped me to understand why this is happening to me," Chastity Murry said. Knowing this"helped me to understand why this is happening to me," Chastity Murry said. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know."That possibility was always there. " Sheng said genetics plays a big part in bipolar disorder, schizoaffective disorder and schizophrenia." Sheng said genetics plays a big part in bipolar disorder, schizoaffective disorder and schizophrenia. But experience and environment also play a big part, and these things interact in subtle ways.” “Yes,” Dante Murry, 50, added with a smile. So it's not like everyone with risk genes is destined to become ill. So it's not like everyone with risk genes is destined to become ill. Morgan said a severe risk gene for schizophrenia, for example, may increase the chance of getting the disease 10-fold. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. Knowing this “helped me to understand why this is happening to me,” Chastity Murry said. Given those odds, parents with the gene might not have any children with the illness. But"if you take a whole extended family that has that risk gene, there will be a number of cases popping up," Morgan said. But"if you take a whole extended family that has that risk gene, there will be a number of cases popping up," Morgan said."It's a roll of the dice. But experience and environment also play a big part, and these things interact in subtle ways." Experts say other illnesses along what some call the"psychosis continuum" are also more likely." Experts say other illnesses along what some call the"psychosis continuum" are also more likely."When you look at a family, if you have one person with schizophrenia, you're more likely to have schizophrenia yourself, but you're also more likely to have bipolar," said Dr. Fernando Goes, a psychiatrist at Johns Hopkins University. Fernando Goes, a psychiatrist at Johns Hopkins University. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. The same is true for schizoaffective disorder, studies show. There are no tests for these conditions — which together affect around 9 million U. There are no tests for these conditions — which together affect around 9 million U.S. “It’s a roll of the dice. adults — so diagnosis is based on history and the sometimes overlapping symptoms. adults — so diagnosis is based on history and the sometimes overlapping symptoms. For instance, psychosis can happen in all three illnesses. This can make diagnosis difficult. This can make diagnosis difficult. Fernando Goes, a psychiatrist at Johns Hopkins University. Sally Littlefield of Oakland, California, was diagnosed with bipolar disorder, then schizoaffective disorder, after spiraling into psychosis during a work meeting in 2018. For 10 months, she was convinced a team of psychologists had assumed control of her life and were experimenting on her against her will. For 10 months, she was convinced a team of psychologists had assumed control of her life and were experimenting on her against her will. At one point during a manic episode, Littlefield wandered the streets of San Francisco, breaking into houses and cars, shoplifting and jumping from one car rooftop to another.S. She was eventually tackled by police and hospitalized. She was eventually tackled by police and hospitalized. She came to realize she was ill when her delusions got so grandiose she believed she was president of the United States. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which"prevents a lot of us from recovering. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which"prevents a lot of us from recovering. This can make diagnosis difficult." A 'VERY LONG JOURNEY'People with mental illness hope stigma fades as doctors learn more about how these disorders arise and affect the brain. A 2019 study said a growing number of experts now recognize that schizophrenia, schizoaffective disorder and bipolar not only share common genetic risk factors and symptoms but also look similar in neuroimaging and may have common treatment regimens. A 2019 study said a growing number of experts now recognize that schizophrenia, schizoaffective disorder and bipolar not only share common genetic risk factors and symptoms but also look similar in neuroimaging and may have common treatment regimens. The mood stabilizer lithium, for example, is often used to treat bipolar and schizoaffective disorder. At one point during a manic episode, Littlefield wandered the streets of San Francisco, breaking into houses and cars, shoplifting and jumping from one car rooftop to another. The recent Broad Institute research may provide clues to how the drug works, since AKAP11 interacts with what's thought to be lithium's target. The recent Broad Institute research may provide clues to how the drug works, since AKAP11 interacts with what's thought to be lithium's target. Other drugs also treat more than one of the illnesses. The Murrys take several of the same medications. The Murrys take several of the same medications. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which “prevents a lot of us from recovering. Someday, experts said genetic insights might allow doctors to intervene earlier in the disease process. While few people get genetic testing now – except perhaps to see how they might react to a particular drug – scientists said that could change in the future. While few people get genetic testing now – except perhaps to see how they might react to a particular drug – scientists said that could change in the future. If people knew their genetic risk and family history, Sheng said, they could seek help if something didn't seem quite right, before an illness caused major problems. The mood stabilizer lithium, for example, is often used to treat bipolar and schizoaffective disorder. Some scientists, while acknowledging common genetic underpinnings of bipolar, schizoaffective disorder and schizophrenia, are skeptical about framing them as on a psychosis continuum, particularly if that leads to changing categories doctors use to diagnose people with each disorder. Some scientists, while acknowledging common genetic underpinnings of bipolar, schizoaffective disorder and schizophrenia, are skeptical about framing them as on a psychosis continuum, particularly if that leads to changing categories doctors use to diagnose people with each disorder. They say the current criteria are useful in deciding treatment and care. Scientists agree that more research is needed. Scientists agree that more research is needed. The Murrys take several of the same medications. Finding new illness risk genes, for instance, is only the first step toward developing new medicines. A Broad"road map" says researchers must also figure out how the genes function, understand disease mechanisms and identify targets for the drugs. A Broad"road map" says researchers must also figure out how the genes function, understand disease mechanisms and identify targets for the drugs. NAMI's Duckworth said it might be"5 to 50 years" before genetic findings translate into changes in clinical practice. If people knew their genetic risk and family history, Sheng said, they could seek help if something didn’t seem quite right, before an illness caused major problems."It's a very long journey."It's a very long journey." Meanwhile, many people living with mental illness rely on peer support in addition to medication and psychotherapy. The Murrys check on each other daily. The Murrys check on each other daily. Scientists agree that more research is needed. "I can always tell when he's having a bad day. He can always tell when I'm having a bad day," said Chastity Murry, who has also been diagnosed with borderline personality disorder and an anxiety disorder. He can always tell when I'm having a bad day," said Chastity Murry, who has also been diagnosed with borderline personality disorder and an anxiety disorder."If I'm acting a little off or something, he'll ask me: Have you taken your meds today? But I don't get offended because I know he's got my best interest in mind. NAMI's Duckworth said it might be “5 to 50 years” before genetic findings translate into changes in clinical practice." Both have also learned and grown from working as volunteers." Both have also learned and grown from working as volunteers. Together, they facilitate support groups twice a week, check in with peers regularly by phone, and have been trained to help people who are suicidal. "This is my path in life, and his path as well," Chastity Murry said. "This is my path in life, and his path as well," Chastity Murry said. The Murrys check on each other daily."We're helping them, but they're also helping us." ___ 10 reasons online mental health therapy has grown over the last decade 10 reasons online mental health therapy has grown over the last decade COVID-19 spurred the need for therapy to go remote COVID-19 also worsened mental health for many Mental illness rates have increased in the last decade Demand has increased for mental health treatment There is less stigma around mental health Online mental health care can be more convenient Online health services are growing Insurers are offering expanded coverage for telehealth Video conferencing has become more mainstream Internet connectivity has improved, particularly in rural areas The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education." ___ 10 reasons online mental health therapy has grown over the last decade 10 reasons online mental health therapy has grown over the last decade COVID-19 spurred the need for therapy to go remote COVID-19 also worsened mental health for many Mental illness rates have increased in the last decade Demand has increased for mental health treatment There is less stigma around mental health Online mental health care can be more convenient Online health services are growing Insurers are offering expanded coverage for telehealth Video conferencing has become more mainstream Internet connectivity has improved, particularly in rural areas The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute's Department of Science Education. The AP is solely responsible for all content. “If I’m acting a little off or something, he’ll ask me: Have you taken your meds today? But I don’t get offended because I know he’s got my best interest in mind. Tags Build your health & fitness knowledge Sign up here to get the latest health & fitness updates in your inbox every week! . Tags Respond: Write a letter to the editor Write a guest opinion Subscribe to stay connected to Tucson.