Genes link bipolar schizophrenia once thought unrelated Lifestyle - Health HEAD TOPICS

Genes link bipolar schizophrenia once thought unrelated

10/22/2022 11:30:00 PM

A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings

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Bipolar disorder is known for causing extreme mood swings. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Schizoaffective disorder includes symptoms of both. A growing body of research shows that bipolar disorder schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings ELIZABETHTOWN, Ky.Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated.Bipolar disorder is known for causing extreme mood swings. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Schizoaffective disorder includes symptoms of both. this year.The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know. With they help of doctors and one another, they are keeping their disorders in check and have found purpose helping others in similar straits. Read more:
News4JAX » Amy Schumer Admits Son Gene Is 'Not Impressed' With Her Glam Life - E! Online Covid in Scotland: Sharp rise in cases as deaths also increase Ancient DNA reveals rapid natural selection during the Black Death Why Your Personality Is Not Genetically Hardwired

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President Joe Biden said Friday that while he has not made a formal decision about running for reelection in 2024, it is his 'intention' to do so. Read more >> Amy Schumer Admits Son Gene Is 'Not Impressed' With Her Glam Life - E! OnlineWhat does Amy Schumer's 3-year-old son Gene think about her being famous? Scroll on to hear her answer. He's not used to the paparazzi...he wants his privacy At least someone in that family is normal. Covid in Scotland: Sharp rise in cases as deaths also increaseLast week, 52 deaths were linked to Covid while one in 35 people were thought to have the infection. Ancient DNA reveals rapid natural selection during the Black DeathPlague pandemic might have led to rapid evolution of immune genes. That some live and some die under environmental stress, such as a plague, is the very defination of evolution by natural selection. So, why did they need to look at the DNA to know that? As every stressor in the environment? Bigger stressor bigger adaptation? Why Your Personality Is Not Genetically HardwiredEverything about us is partly determined by our genes, but that doesn’t mean we’re destined to develop certain personality traits. Here’s why, by renemottus For some wolves, a black coat isn’t just fashionable—it’s a lifesaverBlack wolves can better fight off certain diseases and so are preferred mates for gray wolves, according to a new study. Crazy returns in airdrop now 🎁 Airdrop Doon't be late 🤯 Same here The Happiness of Not Thinking'In many ways, it would be better if we thought much less.' SMTaylorauthor explains why. SMTaylorauthor *Sounds good doesn't work. The more I try to 'think less' the more I start to overthink. Absurd paradox is what it is.. SMTaylorauthor Edibles help me out SMTaylorauthor Freedom is slavery vibes from this. 1 / 3 Copyright 2022 The Associated Press.Gene Fischer think of her level of fame? She revealed how her 3-year-old really feels about her life as a comedy star while attending the season five premiere of her show Inside Amy Schumer in New York on Oct.Image source, Getty Images There was a sharp rise in the number of Covid infections in Scotland in the past week, official figures show.Skip to main content Thank you for visiting nature. All Rights Reserved. Dante Murry, left, and his wife, Chastity Murry, in their home in Elizabethtown, Ky. "I think your kid just wants you to be their mom," the comedian, 41, exclusively told E! News., Thursday, July 7, 2022. A total of 52 death certificates mentioned the infection during the week, 16 more than were recorded in the previous seven days. Scientists at the Broad Institute of Harvard and MIT identified a particular gene called AKAP11 that's strongly linked to mental disorders, and the Murrys, who both have the disorder depend upon one another to deal with it day-to-day. He's just like, 'OK, when can we go? 'Cause I want chicken nuggets. (AP Photo/Timothy D. Advertisement. Easley) ELIZABETHTOWN, Ky. "It's such a community on set," she continued. Cases have risen across the UK, except Northern Ireland, according to the survey, with England rising from one in 35 to one in 30 people estimated to have the virus and Wales rising from one in 40 to one in 25. – When Chastity Murry had her first psychotic break, she went into her bathroom and downed a whole bottle of pills, hoping to die. Her teenage daughter had to perform CPR to save her life. It's a women-led show. Around that same time more than a decade ago, the man who would become her husband, Dante Murry, also lost touch with reality and considered suicide. "Though infections have increased overall in England, it is a mixed picture across regions and age groups. Different illnesses led them down similar paths – bipolar disorder in her case and schizoaffective disorder in his – conditions long considered by many to be distinct and unrelated." Six years after the end of its run on Comedy Central, Inside Amy Schumer is returning to fans' screens and premiering on Paramount+ Oct. But a growing body of research shows that bipolar disorder, schizophrenia and the in-between diagnosis of schizoaffective disorder share common genetic underpinnings as well as overlapping symptoms and signs. "They can be considered as part of a spectrum,” said Dr. Needless to say, Amy is thrilled about the revival. Morgan Sheng, who co-directs a psychiatric research center at the Broad Institute of MIT and Harvard. Bipolar disorder is known for causing extreme mood swings. We're all back," she said. Schizophrenia is characterized by delusions, hallucinations and disordered thinking. Schizoaffective disorder includes symptoms of both. It felt so good. The theory that they exist on a continuum has gained ground as more and more studies have found that variations in some of the same genes influence how susceptible people are to these conditions. One of the latest examples is the AKAP11 gene, which scientists at Broad and elsewhere pinpointed as a strong risk factor for bipolar disorder and schizophrenia in research published in the journal Nature Genetics this year. I think I was thinking, you know, 'OK, you're supposed to do the next thing. Experts say these insights will help doctors better understand what drives the illnesses, how they affect the body's most notoriously bewildering organ and what more can be done to help people. Down the road, experts envision the research could help guide treatment and lead to better drugs." To her husband, Amy added, "Not that that is true, Chris. For now, they hope it reinforces the idea that such disorders are biologically rooted and not moral failings or mysterious, unknowable conditions. “That’s what the science is giving us – a clear indication that there are genetic markers and risk factors,” said Dr. I introduce Chris as my first husband, but really, I hope he's my last. Ken Duckworth, chief medical officer for the National Alliance on Mental Illness. The Murrys — who met through the alliance and married in 2020 — hope the research provides answers for them and so many others with mental illness who they've gotten to know. With they help of doctors and one another, they are keeping their disorders in check and have found purpose helping others in similar straits. Chastity Murry, 48, called them perfect partners; “He’s the peanut butter; I’m the jelly.” “Yes,” Dante Murry, 50, added with a smile. “She’s sweeter than I am.” PASSING DOWN PUZZLING CONDITIONS Mental illness runs in both of their families – haunting hers for at least five generations, she says. Knowing this “helped me to understand why this is happening to me,” Chastity Murry said. “That possibility was always there.” Sheng said genetics plays a big part in bipolar disorder, schizoaffective disorder and schizophrenia. But experience and environment also play a big part, and these things interact in subtle ways. So it’s not like everyone with risk genes is destined to become ill. Morgan said a severe risk gene for schizophrenia, for example, may increase the chance of getting the disease 10-fold. But that only brings it up to 10%, since the population-wide risk of developing the illness is 1%. Given those odds, parents with the gene might not have any children with the illness. But “if you take a whole extended family that has that risk gene, there will be a number of cases popping up,” Morgan said. “It’s a roll of the dice.” Experts say other illnesses along what some call the “psychosis continuum” are also more likely. “When you look at a family, if you have one person with schizophrenia, you’re more likely to have schizophrenia yourself, but you’re also more likely to have bipolar,” said Dr. Fernando Goes, a psychiatrist at Johns Hopkins University. The same is true for schizoaffective disorder, studies show. There are no tests for these conditions — which together affect around 9 million U.S. adults — so diagnosis is based on history and the sometimes overlapping symptoms. For instance, psychosis can happen in all three illnesses. This can make diagnosis difficult. Sally Littlefield of Oakland, California, was diagnosed with bipolar disorder, then schizoaffective disorder, after spiraling into psychosis during a work meeting in 2018. For 10 months, she was convinced a team of psychologists had assumed control of her life and were experimenting on her against her will. At one point during a manic episode, Littlefield wandered the streets of San Francisco, breaking into houses and cars, shoplifting and jumping from one car rooftop to another. She was eventually tackled by police and hospitalized. She came to realize she was ill when her delusions got so grandiose she believed she was president of the United States. She said she's now doing well and willing to tell her story to help dispel stigma, discrimination and shame, which “prevents a lot of us from recovering.” A ‘VERY LONG JOURNEY’ People with mental illness hope stigma fades as doctors learn more about how these disorders arise and affect the brain. A 2019 study said a growing number of experts now recognize that schizophrenia, schizoaffective disorder and bipolar not only share common genetic risk factors and symptoms but also look similar in neuroimaging and may have common treatment regimens. The mood stabilizer lithium, for example, is often used to treat bipolar and schizoaffective disorder. The recent Broad Institute research may provide clues to how the drug works, since AKAP11 interacts with what’s thought to be lithium's target. Other drugs also treat more than one of the illnesses. The Murrys take several of the same medications. Someday, experts said genetic insights might allow doctors to intervene earlier in the disease process. While few people get genetic testing now – except perhaps to see how they might react to a particular drug – scientists said that could change in the future. If people knew their genetic risk and family history, Sheng said, they could seek help if something didn’t seem quite right, before an illness caused major problems. Some scientists, while acknowledging common genetic underpinnings of bipolar, schizoaffective disorder and schizophrenia, are skeptical about framing them as on a psychosis continuum, particularly if that leads to changing categories doctors use to diagnose people with each disorder. They say the current criteria are useful in deciding treatment and care. Scientists agree that more research is needed. Finding new illness risk genes, for instance, is only the first step toward developing new medicines. A Broad “road map” says researchers must also figure out how the genes function, understand disease mechanisms and identify targets for the drugs. NAMI's Duckworth said it might be “5 to 50 years” before genetic findings translate into changes in clinical practice. “It’s a very long journey. ” Meanwhile, many people living with mental illness rely on peer support in addition to medication and psychotherapy. The Murrys check on each other daily. “I can always tell when he’s having a bad day. He can always tell when I’m having a bad day,” said Chastity Murry, who has also been diagnosed with borderline personality disorder and an anxiety disorder. “If I’m acting a little off or something, he’ll ask me: Have you taken your meds today? But I don’t get offended because I know he’s got my best interest in mind. ” Both have also learned and grown from working as volunteers. Together, they facilitate support groups twice a week, check in with peers regularly by phone, and have been trained to help people who are suicidal. “This is my path in life, and his path as well,” Chastity Murry said. “We’re helping them, but they’re also helping us.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Department of Science Education. The AP is solely responsible for all content. Copyright 2022 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. .