What Makes You at Risk for Alzheimer s Researchers Have New Insight HEAD TOPICS
What Makes You at Risk for Alzheimer s Researchers Have New Insight
10/21/2022 6:53:00 PM What Makes You at Risk for Alzheimer s Researchers Have New Insight
Source SciTechDaily
What Makes You at Risk for Alzheimer s Researchers Have New Insight Scientists shed new light on the genetic and molecular machinery that predispose individuals to Alzheimer's disease. Human microglia are immune cells that reside in the brain, and Mount Sinai researchers have attained an unprecedented understanding of their genetic and molecular machinery. This und SPI1Human microglia are immune cells that reside in the brain, anddisease (AD). The study was recently published in the journalResearchers found 21 prospective risk genes using fresh human brain tissue collected by biopsy or autopsy from 150 donors, and they highlighted one, “Our study is the largest human fresh-tissue microglia analysis to date of genetic risk factors that might predispose someone to Alzheimer’s disease,” says senior author Panos Roussos, MD, Ph.D., Professor of Psychiatry, and Genetic and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai and Director of the Center for Disease Neurogenomics. “By better understanding the molecular and genetic mechanisms involved in microglia function, we’re in a much better position to unravel the regulatory landscape that controls that function and contributes to AD. That knowledge could, in turn, pave the way for novel therapeutic interventions for a disease that currently has no effective treatments.” Read more:
SciTechDaily » 5 Early Signs of Dementia Are Blackout Curtains Key Not Just for Sleep, But Improving Long-Term Health? ‘No quick fixes’: Walensky’s push for change at CDC meets reality Drug Repurposing 'Fast Track' to New Medicines for Obesity, Diabetes Potato and Broccoli Soup Recipe
In this soup, broccoli stems cook with the potatoes and are pureed to form a creamy base, while broccoli florets add texture to the finished dish. Read more >> 5 Early Signs of DementiaThese symptoms could provide an early warning that someone is at risk of developing dementia or Alzheimer's disease. Do any of them sound familiar? Are Blackout Curtains Key Not Just for Sleep, But Improving Long-Term Health?New research links light exposure to heart disease, obesity, and Alzheimer’s. ‘No quick fixes’: Walensky’s push for change at CDC meets realityIn an interview with POLITICO, Walensky said it is critical for the CDC to communicate with Americans more quickly — even when it doesn’t know everything. CDCDirector your communications with the American people in the pandemic isn't working so far in this crisis cause you've made CDCgov a laughing stock for not following the mandates in the pandemic as cases have been rising for many months. You've not reported death rates anywh Seems like the CDC did too much communication not too little. No, that's not it. It is important for CDC to get it right. Drug Repurposing 'Fast Track' to New Medicines for Obesity, DiabetesResearchers have developed a computer program to identify drugs for other diseases that might be repurposed to treat T2D and/or obesity by targeting genetic pathways for these two conditions. DrugRepurposing MedTwitter New UK interior minister praises Hunt after mini-budget debacleBritain's new interior minister, Grant Shapps, praised Jeremy Hunt on Wednesday, saying that while the government was having a difficult time, the country's new finance minister, Hunt, was doing a great job. The Mount Sinai Hospital / Mount Sinai School of Medicine October 21, 2022 The study highlighted one gene, SPI1 , as a potential key regulator of microglia and AD risk.Find a therapist to help with dementia Key points While some forms of cognitive decline are common signs of aging, others may predict a future diagnosis of dementia.View saved stories .By Krista Mahr At the same time, Walensky is confronting internal pushback. Scientists shed new light on the genetic and molecular machinery that predispose individuals to Alzheimer’s disease. Human microglia are immune cells that reside in the brain, and researchers have attained an unprecedented understanding of their genetic and molecular machinery. It's important to know that even healthy people can experience mild versions of the same symptoms as those who are developing dementia. This understanding may help shed light on how they contribute to the onset and progression of Alzheimer’s disease (AD). The earth is getting brighter. The study was recently published in the journal Nature Genetics . While your health care provider may assure you that some types of forgetting are simply normal signs of aging, scientists at the University of Cambridge in the UK have determined which changes in brain function could predict future worsening of symptoms and a diagnosis of neurodegenerative disease, including Alzheimer’s disease or a less common form of dementia known as frontotemporal dementia. Researchers found 21 prospective risk genes using fresh human brain tissue collected by biopsy or autopsy from 150 donors, and they highlighted one, SPI1, as a potential key regulator of microglia and AD risk.” Walensky needs help to realize her vision. “Our study is the largest human fresh-tissue microglia analysis to date of genetic risk factors that might predispose someone to Alzheimer’s disease,” says senior author Panos Roussos, MD, Ph. Compared to healthier individuals, those participants who were later given a diagnosis of Alzheimer’s disease or frontotemporal dementia had earlier scored lower on tests that involved five specific areas of concern: Problem-solving. Unfortunately, it’s obscured the Milky Way for an estimated 80% of Americans.D., Professor of Psychiatry, and Genetic and Genomic Sciences, at the Icahn School of Medicine at Mount Sinai and Director of the Center for Disease Neurogenomics. “By better understanding the molecular and genetic mechanisms involved in microglia function, we’re in a much better position to unravel the regulatory landscape that controls that function and contributes to AD. I write this from one of the brightest cities in the world, on the most brilliant street I have ever lived on. That knowledge could, in turn, pave the way for novel therapeutic interventions for a disease that currently has no effective treatments.” Given lawmakers’ appetite for putting more money into public health, help isn’t likely to be on the way anytime soon. ” In addition to being crucial for the development and maintenance of neurons, microglia play a major role in the immune response in the brain. Although prior research, including some from Mount Sinai, has shown that microglia are important for the genetic risk to and progression of Alzheimer’s disease, little is understood about the epigenetic mechanisms behind how this happens. If the insidious dangers of light pollution are alarming, the solution, on an individual, short-term level, is surprisingly simple: We need blackout curtains. The majority of earlier research has either employed animal- or cell-line-based models, which do not accurately represent the true complexity of microglia activity in the brain since microglia are difficult to isolate inside the human brain. Because these risk variables are frequently found in the non-coding region of the genome (formerly known as “junk DNA ”), which is more challenging to analyze, it has been difficult to link genetic risk variance for AD to specific molecular function. The Mount Sinai team’s solution was to access fresh brain tissue from biopsies or autopsies made possible by a collaboration between four brain bio-depositories, three at Mount Sinai and the other from Rush University Medical Center/Rush Alzheimer’s Disease Center. Light is, after all, one of the most significant dictators of the body’s rhythms. ‘Some people may still resist’ This spring, Walensky ordered a review of the CDC’s Covid-19 response and its operations . “Using a total of 150 samples from these sources, we were able to isolate high-quality microglia, which provided unprecedented insights into genetic regulation by reflecting the entire set of regulatory components of microglia in both healthy and neurodegenerative patients,” explains Dr. Roussos. That process—comparing epigenetic, gene expression, and genetic information from the samples of both AD and healthy aged patients—allowed researchers to comprehensively describe how microglia functions are genetically regulated in humans. It poses a consequential threat to our health as research shows that sustained deep sleep is integral to long-term cardiovascular, metabolic, and cognitive health. As part of their statistical analysis, they expanded the findings of prior genome-wide association studies to link identified AD-predisposing genetic variants to specific DNA regulatory sequences and genes whose dysregulation is known to directly contribute to the development of the disease. They further described the cell-wide regulatory mechanisms as a way of identifying genetic regions involved in specific aspects of the microglial activity. It often took days — sometimes weeks — for the CDC to publish infection rates and deaths. From their investigation emerged new knowledge about the SPI1 gene, already known to scientists, as the main microglial transcription factor regulating a network of other transcription factors and genes that are genetically linked to AD. In terms of cognitive health, “now we’re able to recognize that particular stages of sleep are important for removing toxic activity and molecules that develop during different parts of the day,” says Zee, likening them to exhaust produced by a car. Data the team is generating could also be important to deciphering the molecular and genetic mysteries behind other neurodegenerative diseases in which microglia play a role, including Parkinson’s disease, multiple sclerosis, and amyotrophic lateral sclerosis. Dr. Roussos concedes that much work remains for his team to fully understand how the identified genes contribute to the development and progression of Alzheimer’s disease, and how they could be targeted with new therapeutics. A total of 50% of our genes are tasked with keeping the body’s many systems (skin, liver, immune, reproductive, cardiovascular, kidney, and lungs) on track. He is greatly encouraged, though, by the results of single-cell analysis by his lab of microglia using highly sophisticated instruments that are uncovering the unique interactions between different types of immune cells in the brain and its periphery that are related to neurodegenerative disease. “And these are essential data. “We’re seeing very exciting results through our single-cell data,” Dr. Roussos reports, “and that’s bringing us ever closer to understanding the genetically driven variations and cell-specific interactions of inheritable diseases like Alzheimer’s. This circadian confusion is why we experience fatigue, constipation, brain fog, and the inability to focus when we’re jet-lagged.” Reference: “Genetics of the human microglia regulome refines Alzheimer’s disease risk loci” by Roman Kosoy, John F. Fullard, Biao Zeng, Jaroslav Bendl, Pengfei Dong, Samir Rahman, Steven P. Kleopoulos, Zhiping Shao, Kiran Girdhar, Jack Humphrey, Katia de Paiva Lopes, Alexander W. At home, Zee has placed a small patch over the diminutive blue lights that mark where her bedroom light switches are. A CDC study that looked at how well the was working was an early test of the new workplace philosophy. Charney, Brian H. Kopell, Towfique Raj, David Bennett, Christopher P. Kellner, Vahram Haroutunian, Gabriel E. A more perfect darkness can be found in blackout curtains. Hoffman, and Panos Roussos, 5 August 2022, Nature Genetics .