A radioactive tumor implant is a major breakthrough for treating pancreatic cancer Pancreatic Cancer - Cancer HEAD TOPICS
A radioactive tumor implant is a major breakthrough for treating pancreatic cancer
10/21/2022 8:00:00 PM The new approach completely eliminates the deadly tumors as opposed to most methods that solely halt their growth
Pancreatic Cancer Cancer
Source Interesting Engineering
The new approach completely eliminates the deadly tumors as opposed to most methods that solely halt their growth Researchers at the Duke University have developed an approach that dissolves pancreatic tumors, producing the best results in mouse trials . The implantation method includes a substance made of elastin-like polypeptides (ELPs), "which are synthetic chains of amino acids bonded together to form a gel-like substance with tailored properties," according to the release.Though the ELPs exist in a liquid state at room temperature, they form a stable gel-like substance within the warmer human body. The ELPs were injected into a tumor along with , which resulted in the formation of a small depot encasing radioactive atoms.Most PopularThis depot encases the iodine-131 and prevents it from leaking into the body. According to the release, the iodine-131 emits beta radiation, which penetrates the bio gel and "deposits almost all its energy into the tumor without reaching the surrounding tissue." Over time, the ELP depot is absorbed by the body — "but not before the iodine-131 has decayed into a harmless form of xenon". Read more:
Interesting Engineering » Cell biologist from Duke named new president of MIT M.I.T. Names a Duke Provost as Its New President Paolo Banchero Says He Loved Duke, But Felt Like 'Zoo Animal' At School Prince Harry Shares His Eye-Opening Experience With Therapy Hacking - CNN
CNN News, delivered. Select from our newsletters below and enter your email to subscribe. Read more >> Cell biologist from Duke named new president of MITSally Kornbluth, a cell biologist who has spent the past eight years as provost at Duke University, was named president of the Massachusetts Institute of Technology on Thursday. M.I.T. Names a Duke Provost as Its New PresidentSally Kornbluth, a cell biologist, is the second woman to lead the university. The provost, chancellor, dean of science and chair of corporation are also all women. Paolo Banchero Says He Loved Duke, But Felt Like 'Zoo Animal' At SchoolPaolo Banchero said sometimes he felt like straight up 'a zoo animal' during his time on the Duke campus. The media tryna spin this into something it’s not lol. I bet every African American fells the same way on that campus! Prince Harry Shares His Eye-Opening Experience With TherapyThe Duke of Sussex made a surprise appearance at the Masters of Scale Summit on Wednesday. The Wimp of Sussex Harry!!!! Stop yapping!!! Go away and live your life It is very important, thank you for spreading the word. After my son’s suicide I thought I could handle it. I did with Zanax and Vicodin. ALMOST took my life, thank God my Nurse Daughter was watching me! I would not be here today 20 years later without her love & care & THERAPY Prince Harry makes surprise appearance in San FranciscoThe Duke of Sussex was in the Presidio on Wednesday evening. Who fucking cares? Well done Prince Harry 👏🏾 It's good Prince Harry, you're on the right track James Little, Unapologetic Abstractionist Painter, Catches the LimelightJames Little waited more than 40 years to show his work in the Whitney Biennial. This year, he prepares for two gallery shows and a collaboration with Duke Ellington’s music. Combining traditional chemotherapy with a new method The implantation method includes a substance made of elastin-like polypeptides (ELPs), "which are synthetic chains of amino acids bonded together to form a gel-like substance with tailored properties," according to the release.announced that he planned to step down after 10 years on the job.Ms.The Young Person Basketball Podcast " . Though the ELPs exist in a liquid state at room temperature, they form a stable gel-like substance within the warmer human body. The ELPs were injected into a tumor along with , which resulted in the formation of a small depot encasing radioactive atoms. As provost at the North Carolina school since 2014, Kornbluth was responsible for carrying out Duke’s teaching and research missions; developing its intellectual priorities; and partnering with others to improve faculty and students. Most Popular This depot encases the iodine-131 and prevents it from leaking into the body.T. According to the release, the iodine-131 emits beta radiation, which penetrates the bio gel and "deposits almost all its energy into the tumor without reaching the surrounding tissue. “The ethos of MIT, where groundbreaking research and education are woven into the DNA of the institution, is thrilling to me,” Kornbluth said in a statement released by MIT." Over time, the ELP depot is absorbed by the body — "but not before the iodine-131 has decayed into a harmless form of xenon".. Schaal and his team tested the new treatment with a commonly used chemotherapy drug, paclitaxel, on various mouse models of pancreatic cancer. And when it comes to the impact of that work, MIT is unparalleled — in the power of its innovations, in its ability to move those innovations into the world, and in its commitment to discovery, creativity, and excellence. Credit. The researchers tested the method on mice with cancers just under their skin created by several different mutations known to occur in pancreatic cancer and on mice that had tumors within the pancreas, which is much more difficult to treat. The tumors were eliminated in three-quarters of the mouse models about 80 percent of the time The tests saw a 100 percent response rate across all models, "with the tumors being completely eliminated in three-quarters of the models about 80 percent of the time". "We think the constant radiation allows the drugs to interact with its effects more strongly than external beam therapy allows," Schaal said. Cody O'Loughlin for The New York Times By Oct. "That makes us think that this approach might actually work better than external beam therapy for many other cancers, too.. " Next, the researchers will test their approach on large animals, after which they will look toward a Phase 1 clinical trial in humans. "My lab has been working on developing new cancer treatments for close to 20 years, and this work is perhaps the most exciting we have done in terms of its potential impact, as late-stage pancreatic cancer is impossible to treat and is invariably fatal," Chilkoti said. ET M. "Pancreatic cancer patients deserve than are currently available, and I am deeply committed to taking this all the way into the clinic." Study Abstract: Locally advanced pancreatic tumours are highly resistant to conventional radiochemotherapy. Here we show that such resistance can be surmounted by an injectable depot of thermally responsive elastin-like polypeptide (ELP) conjugated with iodine-131 radionuclides (131I-ELP) when combined with systemically delivered nanoparticle albumin-bound paclitaxel. announced the selection of a new president, Sally Kornbluth, a cell biologist and provost at Duke University." Banchero even said students would bring their entire families to his dorm room -- just to get a peek at the basketball standout. This combination therapy induced complete tumour regressions in diverse subcutaneous and orthotopic mouse models of locoregional pancreatic tumours. 131I-ELP brachytherapy was effective independently of the paclitaxel formulation and dose, but external beam radiotherapy (EBRT) only achieved tumour-growth inhibition when co-administered with nanoparticle paclitaxel. Histological analyses revealed that 131I-ELP brachytherapy led to changes in the expression of intercellular collagen and junctional proteins within the tumour microenvironment.I. These changes, which differed from those of EBRT-treated tumours, correlated with the improved delivery and accumulation of paclitaxel nanoparticles within the tumour. Our findings support the further translational development of 131I-ELP depots for the synergistic treatment of localized pancreatic cancer. "It was a good experience, though," he said. SHOW COMMENT . The corporation elected Dr.