Addiction Drug Shows Promise Lifting Long COVID Brain Fog Fatigue Coronavirus HEAD TOPICS

Addiction Drug Shows Promise Lifting Long COVID Brain Fog Fatigue

10/21/2022 7:12:00 PM

Addiction drug naltrexone shows promise for the brain fog associated with Long COVID

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Medscape

Addiction drug naltrexone shows promise for the brain fog associated with Long COVID Lauren Nichols, a 34-year-old logistics expert for the U.S. Department of Transportation in Boston, has been suffering from impaired thinking and focus, fatigue, seizures, headache and pain since her COVID-19 infection in the spring of 2020. Unlike treatments aimed at addressing specific symptoms caused by COVID damage to organs, such as the lungs, low-dose naltrexone (LDN) may reverse some of the underlying pathology driving symptoms, they said.Naltrexone has anti-inflammatory properties and has been used at low doses for years to treat conditions such as fibromyalgia, Crohn's disease and multiple sclerosis, said Dr. Jarred Younger, director of the Neuro-inflammation, Pain and Fatigue Laboratory at the University of Alabama at Birmingham. Read more:
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CNN News, delivered. Select from our newsletters below and enter your email to subscribe. Read more >> Addiction drug shows promise lifting long COVID brain fog, fatigueLauren Nichols, a 34-year-old logistics expert for the U.S. Department of Transportation in Boston, has been suffering from impaired thinking and focus, fatigue, seizures, headache and pain since her COVID-19 infection in the spring of 2020. Are there statistics available to determine what percentage of these so called long COVID cases are among the vaccinated? seems curious to me that it is not mentioned. Plumshuga: The Rise of Lauren Anderson“In the play, you see this person on stage in command and doing their thing at the height of the deal and then what’s going on behind the scenes.” A new performance serves as memoir of the life of Lauren Anderson. A Q&A by LiseDigger: Dance HoustonTX Susan L. Schulman Dies: Longtime Broadway Publicist Worked With Lauren Bacall, Vanessa Redgrave & Katharine HepburnSusan L. 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Here Are Voices for Each SideNBC10 political reporter Lauren Mayk talked with a supporter and an opponent of abortion rights for two discussions in her ongoing series of talks on the Nov. 8 midterm elections. The major issue is the economy,fossil fuels, and food and heat, not abortion rights... multiple polls throughout the nation have proven that ...that's from left and right leaning groups ...a swing and a miss again guys Last June, her doctor suggested low doses of naltrexone, a generic drug typically used to treat alcohol and opioid addiction..: I know for years you danced the role of the Sugar Plum Fairy in the Nutcracker .with Glenn Close, Richard Dreyfus and Gene Hackman, A Streetcar Named Desire starring Jessica Lange and Alec Baldwin, and The Madwoman of Chaillot with Kim Hunter and Anne Jackson. After more than two years of living in"a thick, foggy cloud," she said,"I can actually think clearly." Researchers chasing long COVID cures are eager to learn whether the drug can offer similar benefits to millions suffering from pain, fatigue and brain fog months after a coronavirus infection. The drug has been used with some success to treat a similar complex, post-infectious syndrome marked by cognitive deficits and overwhelming fatigue called myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS).” I heard her say it. Drawing on its use in ME/CFS and a handful of long COVID pilot studies, there are now at least four clinical trials planned to test naltrexone in hundreds of patients with long COVID, according to a Reuters review of Clinicaltrials.gov and interviews with 12 ME/CFS and long COVID researchers. Winkler, the and Barry star, was among the clients that provided blurbs for the book: “Take this backstage tour from an insider who lived it,” he wrote. It is also on the short list of treatments to be tested in the U. And I don’t think I ever told her but my dad used to call me “SHUGA BUGGA.S. National Institutes of Health's $1 billion RECOVER Initiative, which aims to uncover underlying causes and find treatments for long COVID, advisers to the trial told Reuters. Unlike treatments aimed at addressing specific symptoms caused by COVID damage to organs, such as the lungs, low-dose naltrexone (LDN) may reverse some of the underlying pathology driving symptoms, they said. I told her the stories that I always tell when I told my story, the fluff part, and we were talking about it in 2019. Naltrexone has anti-inflammatory properties and has been used at low doses for years to treat conditions such as fibromyalgia, Crohn's disease and multiple sclerosis, said Dr. Jarred Younger, director of the Neuro-inflammation, Pain and Fatigue Laboratory at the University of Alabama at Birmingham. At 50 milligrams - 10 times the low dose - naltrexone is approved to treat opioid and alcohol addiction.  And we had more frequent interviews on Zoom and we really got to know each other. Several generic manufacturers sell 50mg pills, but low-dose naltrexone must be purchased through a compounding pharmacy. Younger, author of a scientific review of the drug as a novel anti-inflammatory, in September submitted a grant application to study LDN for long COVID."It should be at the top of everyone's list for clinical trials," he said. But I had a certain amount of trust in her because we’ve become really close. Still, the drug is unlikely to help all patients with long COVID, a collection of some 200 symptoms ranging from pain and heart palpitations to insomnia and cognitive impairment. One 218-patient ME/CFS study found 74% had improvements in sleep, reduced pain and neurological disturbances. "It's not a panacea," said Jaime Seltzer, a Stanford researcher and head of scientific outreach for the advocacy group MEAction. I also knew I was going to write a book and my mentor Ben Stevenson [the Houston Ballet’s former artistic director]."These people weren't cured, but they were helped." 'HUMAN AGAIN' Dr. Jack Lambert, an infectious disease expert at University College Dublin School of Medicine, had used LDN to treat pain and fatigue associated with chronic Lyme disease.” So Ben knew. During the pandemic, Lambert recommended LDN to colleagues treating patients with lingering symptoms after bouts of COVID. It worked so well that he ran a pilot study among 38 long COVID patients. They reported improvements in energy, pain, concentration, insomnia and overall recovery from COVID-19 after two months, according to findings published in July. But they knew. Lambert, who is planning a larger trial to confirm those results, said he believes LDN may repair damage of the disease rather than mask its symptoms. Other planned LDN trials include one by the University of British Columbia in Vancouver and a pilot study by Ann Arbor, Michigan-based startup AgelessRx. That study of 36 volunteers should have results by year-end, said company co-founder Sajad Zalzala.E. Scientists are still working on explaining the mechanism for how LDN might work. Experiments by Dr. Sonya Marshall-Gradisnik of the National Centre for Neuroimmunology and Emerging Diseases in Australia suggest ME/CFS and long COVID symptoms arise from a significant reduction in function of natural killer cells in the immune system. Mouton, a former Houston poet laureate, creating something beautiful and a kind of an artist mashup. In laboratory experiments, LDN may have helped restore their normal function, a theory that must still be confirmed. Others believe infections trigger immune cells in the central nervous system called microglia to produce cytokines, inflammatory molecules that cause fatigue and other symptoms associated with ME/CFS and long COVID. Younger believes naltrexone calms these hypersensitized immune cells.E. Dr. Zach Porterfield, a virologist at the University of Kentucky who co-chairs a RECOVER task force looking at commonalities with other post-infectious syndromes, said it has recommended LDN be included in RECOVER's treatment trials. Other therapies under consideration, sources said, were antivirals, such as Pfizer Inc's Paxlovid, anti-clotting agents, steroids and nutritional supplements. We’ve got a black woman that composed it. RECOVER officials said they have received dozens of proposals and could not comment on which drugs will be tested until trials are finalized. Dr. Hector Bonilla, co-director of the Stanford Post-Acute COVID-19 Clinic and a RECOVER adviser, has used LDN in 500 ME/CFS patients, with about half reporting benefits. I mean, it’s woman-heavy—woman-STRONG. He studied LDN in 18 long COVID patients, with 11 showing improvements, and said he believes larger, formal trials could determine whether LDN offers a true benefit. Nichols, a patient adviser to RECOVER, was"ecstatic" when she learned LDN was being considered for the government-funded trials. While LDN has not fixed all her COVID-related problems, Nichols can now work all day without breaks and have a social life at home. Wherever, anywhere."It has made me feel like a human again." (Reporting by Julie Steenhuysen in Chicago; Editing by Caroline Humer and Bill Berkrot) Reuters Health Information © 2022  My Alerts .