JAK Inhibitors Show No Excess CV Safety Signal - Ra HEAD TOPICS

JAK Inhibitors Show No Excess CV Safety Signal

10/21/2022 12:22:00 PM

JAK inhibitors tofacitinib and baricitinib may pose no greater risk than adalimumab for MACEs or VTE

Rheumatoid Arthritis Ra

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Medscape

JAK inhibitors tofacitinib and baricitinib may pose no greater risk than adalimumab for MACEs or VTE Compared with adalimumab, JAK inhibitors presented no higher risk for major adverse cardiovascular events or venous thromboembolism in patients with rheumatoid arthritis . "I don't know why the FDA decided to treat them differently," Winthrop said.Boxed Warnings Encourage Caution, Lock Treatment SequenceMichael Thakor, MD, of Arthritis & Rheumatology Clinic of Northern Colorado, Fort Collins, supports the boxed warnings because they encourage caution and transparency. "It forces you to have that discussion with your patient, which may take some time, but it's actually a very good thing," Thakor said in an interview."Some patients will say, 'Oh my gosh, I don't want to take that drug.' But most patients, considering the level of risk that you're talking about, are actually okay going ahead with the medication." Read more:
Medscape » Council Uses Its (Public) Power to Soften Austin Energy Rate Hike Study shows majority of gun owners support specific gun safety policies Gloucestershire NHS boss vows to stay despite damning report EV supply chains have a human rights problem. Can tech fix it?

Who will replace Truss as UK prime minister Sunak Mordaunt Johnson

Liz Truss quit on Thursday after the shortest, most chaotic tenure of any British prime minister, forced out after her economic programme shattered the country's reputation for financial stability and left many people poorer. Read more >> Council Uses Its (Public) Power to Soften Austin Energy Rate HikeAustin Energy says it needs to recover $104 million in excess costs. Study shows majority of gun owners support specific gun safety policiesGun policy is a polarizing topic on the campaign trail — but voters may not be as divided as they seem. A new study found broad support among Republican and Democratic gun owners for laws aiming to keep those at high risk of violence from getting guns. Add the right to self preservation. Self protection with the house blender!! Greed is the only reason that policy change doesn’t happen. shannonrwatts Another pretty much meaningless study. There are no nationwide votes for laws. The republicans are scheming to deny votes. Those are state level efforts. Where’s the breakdown by state? That’s where the laws are enacted. Gloucestershire NHS boss vows to stay despite damning reportInspectors raised concerns about surgical safety, bullying and racial discrimination. Sounds all too familiar. EV supply chains have a human rights problem. Can tech fix it?Car makers struggling with environmental and safety issues are turning to sophisticated tracking programs. When has tech fixed anything? It’s only worsened socioeconomic,racial,and political issues. lol You gotta be some kinda ecological terrorist to own an EV sans boxed warning, suggesting inconsistency in the FDA's approach.A benefit of buying electricity from a publicly owned utility like Austin Energy is that you can vote for the people who have to sign off on rate increases before AE executives can implement them.97Percent, a bipartisan group of gun owners and non-gun owners that conducts research on gun safety policies, surveyed 1,078 gun owners nationwide to examine their perceptions of specific gun safety policy details.GLOUCESTERSHIRE HOSPITALS NHS TRUST Image caption, Ms Lee said she hoped she could help the health trust regain its overall "good" rating By Ollie Pritchard-Jones & Carmelo Garcia LDRS An NHS hospital boss has vowed to stay in her role despite a recent damning report. The agent headlines as a"TYK2 inhibitor," but TYK2 is a member of the JAK family. "I don't know why the FDA decided to treat them differently," Winthrop said. Austin Energy ratepayers will soon be those someones, following an 8-3 vote by Council to increase the pass-through charge imposed on AE customers for the cost of generation, known as the Power Supply Adjustment . Boxed Warnings Encourage Caution, Lock Treatment Sequence Michael Thakor, MD , of Arthritis & Rheumatology Clinic of Northern Colorado, Fort Collins, supports the boxed warnings because they encourage caution and transparency. The report found that three-quarters of gun owners are concerned about school shootings, and 71 percent are concerned about mass shootings. "It forces you to have that discussion with your patient, which may take some time, but it's actually a very good thing," Thakor said in an interview.) The PSA portion of AE customer bills will increase $15 per month, as the utility seeks to recoup $104 million in emergency operations costs incurred in the chaotic 2022 fiscal year, in the aftermath of the prior year's grid failures."Some patients will say, 'Oh my gosh, I don't want to take that drug. 'Poor culture' But inspectors found leaders did not always use the organisation's values to improve the culture and services for patients, the Local Democracy Reporting Service said. ' But most patients, considering the level of risk that you're talking about, are actually okay going ahead with the medication. That and this year's unusually hot summer, which appears to have just ended, led to unexpected costs for AE, as did the Winter Storm Uri Brazos Electric ; the cooperative serving Waco owed $27 million to AE. These beliefs aren’t restricted to Democrats or independents — Republican gun owners hold these views as well." If these risks aren't discussed, he noted, patient trust may falter. "They're going to go online, and they're going to be reading about it," Thakor said."Your publicly owned utility has already expended these dollars to provide you with electricity," Council Member Kathie Tovo said before the vote."And then they tend to get more spooked. “The most important finding was that there is a wide enough area of common ground between gun owners and non-gun owners that we believe that is sufficient in order to carve out policies that would be extremely effective. They also may question your advice from then on, if you're not telling them the possible risk." That clear-eyed view on the rate increase among the Council majority did free up three CMs ( Vanessa Fuen­tes. Image source, Image caption, Services at the trust's two hospitals were criticised in the report Ms Lee - who earns an annual salary of £265,000 as the trust's chief executive - told councillors at a Gloucestershire County Council health overview and scrutiny committee meeting on Tuesday that its content were a "really hard read" for her. " Reflecting on the present study, Thakor said that the findings initially appeared reassuring, but he became concerned about the lack of power and how adverse events trended higher in the JAK inhibitor group, particularly for VTEs, most of which occurred with baricitinib. This latter finding is challenging to interpret, however, because the 4-mg dose is not used in the United States, he added. Additionally, when specific provisions are included in gun laws, support from gun owners increases. Thakor described how JAK inhibitors once seemed poised to assume a frontline role in RA until the boxed warnings came out. These safety concerns don't take JAK inhibitors off the table, he said, but they do keep the class further down the treatment sequence, and the present data don't alter this picture in daily practice. "If I had a patient who was over the age of 50 with at least one cardiovascular risk factor, I might have a little bit of concern, but if they need their RA treated, I would definitely discuss the possibility of using a JAK inhibitor," Thakor said. Republican gun owners support that measure at the same level.. "If the patient is comfortable with it, then I would feel comfortable going ahead." The investigators disclosed no outside funding or conflicts of interest. Winthrop disclosed relationships with AbbVie, AstraZeneca, Bristol-Myers Squibb, and others. That support is even lower among Republican gun owners: 16 percent. Thakor disclosed no conflicts of interest. Ann Rheum Dis. .” In June, President Joe Biden signed a bipartisan gun safety bill — Congress’ first major response to mass shootings in nearly three decades.