San Francisco 49ers vs Seattle Seahawks Odds Line Picks and Prediction - September 18 2022 NFL Regular Season × Follow Us Create Notifications New User posted their first comment this is comment text Link Approve Reject & ban Delete Log in Manage your profile Editing Story Queue Video Queue Editing Stats Writer Home SEO Redirection Admin Gaming Wiki Edits Taxonomy Home Edit Site Menu Mapping Dashboard Tag Pages Community Social Feed Queue Feed Center Notification Center Affiliate Home Manage Pages Bottom Tagline Dash Timeless Stories Logout Free Betting Picks NFL Draft Preview San Francisco 49ers vs Seattle Seahawks Odds Line Picks and Prediction - September 18 2022 NFL Regular Season By Lucas Abrenica Modified 18 Sep 2022 Follow Us Share San Francisco 49ers vs. Seattle Seahawks The San Francisco 49ers will host the Seattle Seahawks on Sunday. The Niners lost 19-10 to the Chicago Bears in an ugly contest. Meanwhile, the Seahawks squeaked by Russell Wilson and the Denver Broncos, 17-16. These NFC West teams will have an added incentive for this matchup as divisional games are crucial down the stretch. Seattle Seahawks@SeahawksCount it down. 24 hours til kickoff. Next up: #SEAvsSF on FOX68073Count it down. 24 hours til kickoff. Next up: #SEAvsSF on FOX https://t.co/Lw6xbf20Ks "Count it down. 24 hours til kickoff. Next up: #SEAvsSF on FOX" - @Seahawks The 49ers had a rough start, losing to the Bears in terrible conditions last weekend. San Francisco was favored by 6.5 points, but they were unable to assert themselves. Trey Lance's debut was subpar, to say the least, as the rookie completed just 46.4% of his 28 attempts. He threw a pick, too, and failed to record a TD, so he'll look to bounce back against Seattle. The run game was actually solid for San Francisco, which is surprising since they only totaled 10 points. As a team, they recorded 176 yards on 4.8 yards per carry, but it ultimately wasn't enough. For Seattle, they pulled off the upset at home against the Broncos. They scored 17 in the first half, and the defense did enough to hold on in the second half to secure the victory. The second half saw just three points combined, but a lot of this had to do with two goalline fumbles from Denver. The new starting quarterback, Geno Smith, played great, tallying 195 yards and two TDs. His completion rate was excellent, and he targeted several receivers in the win. We'll see if he can have similar success against what should be a stronger 49er defense. Last year, Seattle won both head-to-head matchups, but of course, now they're without Russell Wilson. San Francisco is a pretty big favorite this afternoon, but expect the road team to fight hard in this divisional matchup. San Francisco 49ers vs Seattle Seahawks Match Details Fixture: Seattle Seahawks @ San Francisco 49ers Date & Time: Sunday September 18, 4.05 PM EDT Venue: Levi's Field, San Francisco San Francisco 49ers vs Seattle Seahawks Betting Odds TeamMoney LineSpreadOver/UnderSeattle Seahawks+350+9.5 (-110)Over 40.5 (-110)San Francisco 49ers-450-9.5 (-110)Under 40.5 (-110) San Francisco 49ers vs Seattle Seahawks Betting Prediction The Seahawks proved oddsmakers wrong last week, and they are expected to be shut down this week too. Back Geno Smith and the Seahawks' offense to score at least 15 points today as they have enough weapons to put pressure on San Francisco's defense. Prediction Seahawks Team Total Points Over 14 5 -115 Poll : 0 votes Quick Links More from Sportskeeda Edited by Yasho Amonkar × Feedback Thank You! More from Sportskeeda Fetching more content... GIF Comment in moderation 0 0 Reply x Edit Delete Delete the comment? 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