Cedars-Sinai Physicians Testing Experimental Regimen for Small Cell Lung Cancer Patients Skip to main content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Menu Close Call 1-800-CEDARS-1 toggle search form Close 12 November 2013 23:41 PM America/Los_Angeles Cedars-Sinai Physicians Testing Experimental Regimen for Small Cell Lung Cancer Patients Patients in Study Must Be Newly Diagnosed with Extensive Stage Disease and Have No Prior Treatment History Including Radiation Chemotherapy or Surgery Los Angeles - Nov. 13, 2013 - Alain C. Mita, MD, is fighting an uphill battle against small cell lung cancer. Despite the severity of the disease, the standard-of-care treatment remains the same today as it was nearly 30 years ago. Small cell lung cancer, which includes oat cell carcinoma, is a more aggressive disease than other types of lung cancer and often is more advanced at the time of diagnosis. Smoking is the most common cause of the diagnosis and can be diagnosed even decades after an individual has quit. At advanced stages of the disease, it is incurable in the vast majority of patients, with a median survival less than 12 months. Mita said that following a diagnosis of small cell lung cancer, most patients opt for immediate chemotherapy using the standard-of-care chemotherapy's etoposide and cisplatin - two drugs developed more than three decades ago. This standard chemotherapy regimen responds well initially, many times putting patients into remission. But, within months, most patients relapse and their disease recurs. Today, a new Cedars-Sinai Phase I-II clinical trial may improve treatment approaches and combat disease recurrence. But first, Mita needs to find patients to participate in the clinical trial. "Our team of physician scientists is committed to advancing treatment options for patients diagnosed with small cell lung cancer and other types of lung disease," said Mita, co-director of the Experimental Therapeutics Program at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute. "The eligibility criteria for this specific clinical trial can be a challenge, as patients must have no treatment history. Our team encourages patients and their treating physician to consider available clinical trials that include the combination of the standard of care and a novel agent." The approach being tested in the clinical trial works by combining the standard-of-care chemotherapy (etoposide and cisplatin) with a NOTCH inhibitor (OMP-59R5), a targeted therapy aimed to directly attack cancerous stem cells. Patients interested in small cell lung cancer or other clinical trials at Cedars-Sinai may visit http://cancertrialinfo.csmc.edu or contact Jaime Richardson, RN, clinical trial navigator at the Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, at 310-423-2133 or [email protected]. Co-investigators include Monica Mita, MD, co-director of the Experimental Therapeutics Program, Ronald Natale, MD, medical director of the Clinical Lung Cancer Program, and Edward Wolin, MD, co-director of the Carcinoid and Neuroendocrine Tumor Program. Study name: A phase Ib/II study of OMP-59R5 in combination with etoposide and cisplatin in subjects with untreated extensive stage small cell lung cancer. Share this release Cedars-Sinai Physicians Testing Experimental Regimen for Small Cell Lung Cancer Patients Share on: Twitter Share on: Facebook Share on: LinkedIn Search Our Newsroom Social media Visit our Facebook page (opens in new window) Follow us on Twitter (opens in new window) Visit our Youtube profile (opens in new window) (opens in new window) Latest news 07 Oct 2022 - HealthDay: Black Women Less Likely to Get Laparoscopic Fibroid Surgeries 07 Oct 2022 - Faculty Publications: Sept. 29-Oct. 6 07 Oct 2022 - Fine-Tuning Organ-Chip Technology 06 Oct 2022 - KCRW: Want New Omicron Booster? Wait at Least 2 Months After Last Shot 05 Oct 2022 - Cedars-Sinai Schedules Free Flu Vaccine Clinics 04 Oct 2022 - Cedars-Sinai Showcases Hispanic and Latinx Art Newsroom Home