Van Eyk Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Van Eyk Lab The Van Eyk Laboratory is interested in the molecular basis behind a variety of cardiovascular disorders. Our projects range from basic discovery research to clinically relevant analytical studies. The common thread that runs through these projects is proteomics. We apply our considerable mass spectrometry-based expertise to deciphering the precise role that protein expression profiles and modifications play in disease progression. In brief, we are interested in how alterations to the proteome affects physiology. Our expertise is in merging interesting biological questions with leading-edge analytical techniques, including mass spectrometry, that help decipher protein identities, quantities and modifications. The Van Eyk Laboratory is affiliated with the Cedars-Sinai Smidt Heart Institute and the Advanced Clinical Biosystems Research Institute at Smidt Heart Institute. Personal Statement Our central philosophy is that compelling biological and clinical questions drive innovation through development, optimization and adaption of proteomic technologies, functional analysis and large-scale data handling. The primary research in our lab focuses 1) on understanding the molecular mechanism underlying acute and chronic disease and treatment therapies and 2) in the development of clinically robust circulating biomarkers including detailed exosome constituents." Jennifer Van Eyk, PhD Breakthrough Research Areas Maladaptive Proteomic Signaling in Aortic Aneurysm and Transforming Growth Factor Beta (TGFβ) Vasculopathies Proteomics in Cardiac Resynchronization Therapy for Heart Failure Protein Citrullination in Cardiac, Neurodegenerative and Autoimmune Diseases Biomarker Discovery and Validation—The WISE Study Programs of Excellence in Glycosciences—Glycobiology Collaborations & Resources Collaborations Bernstein Laboratory Department of Medicine Freeman Laboratory Gottlieb Laboratory Allen S. Ho, MD Kimia Sobhani, PhD Barbra Streisand Women's Heart Center Svendsen Laboratory Precision Biomarker Laboratories Resources The Van Eyk Laboratory primarily relies on modern mass spectrometry instrumentation to help pursue their scientific solutions. The following abbreviated list includes the workhorse instruments used for their research: Orbitrap Elite (Thermo Scientific) 5600 Triple TOF (SCIEX) 6600 Triple TOF (SCIEX) Q Exactive (Thermo Scientific) 6500 Triple Quad (SCIEX) Sample Processing Automated Workstation (Beckman Coulter) Simoa Workstation (Quanterix) Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Van Eyk Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Transgenic mouse model of stunned myocardium. Murphy AM, Kogler H, Georgakopoulos D, McDonough JL, Kass DA, Van Eyk JE, Marbán E. Science 2000;287(5452):488-491. Cytoprotective role of the Ca2+-activated K+ channels in cardiac inner mitochondrial membrane. Xu W, Liu Y, Wang S, McDonald T, Van Eyk JE, Sidor A, O’Rourke B. Science 2002;298(5595):1029-1033. Human proteinpedia enables sharing of human protein data. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouz LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, et al. Nat Biotechnol. 2008;26(2):164-167. Contact the Van Eyk Lab 127 S. San Vicente Blvd. Pavilion, 9th Floor Los Angeles, CA 90048 Send A Message Please ensure Javascript is enabled for purposes of website accessibility