Targan Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Targan Lab Inflammatory bowel disease (IBD) refers to a spectrum of complex gastrointestinal disorders, with Crohn's disease and ulcerative colitis representing opposite ends of the spectrum. Stephan R. Targan, MD, leads the Targan Laboratory and is director of the Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute. In these roles, his mission is to use translational research concepts and sophisticated data analytics to research IBD from all angles. The goal is to accelerate findings at the research bench and develop treatments beneficial in patient care. The Targan Laboratory seeks to define the functional relationships between genes, the environment and the immune response to translate these discoveries into a better understanding of the underlying causes of IBD and improved therapies. The Targan Laboratory is affiliated with the Cedars-Sinai Inflammatory Bowel and Immunobiology Research Institute, Inflammatory Bowel Disease Center, Medicine Department and Precision Health. Personal Statement I have been engaged in the study of inflammatory bowel disease (IBD) for four decades and have been treating patients with IBD during this time. My research interests span clinical, basic and translational research and are primarily focused on immunopathologic mechanisms, discovery of novel therapeutics and the translation of basic science and genetic findings for use in diagnosis, prognosis and targeted therapeutic selection in IBD. My goal is to combine all of these areas so that the right patient gets the right treatment at the right time and in the right way." Stephan Targan, MD Breakthrough Research Areas The Targan Laboratory and other research laboratories in the F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute (IBIRI) focus primarily on the genetic and immunopathologic mechanisms of inflammatory bowel disease (IBD). Combining multiple research disciplines of IBD and translating findings for therapeutic development is a unique feature of the IBIRI laboratories under the Targan Lab umbrella. Collaborations & Resources Collaborations Barrett Laboratory Board of Governors Regenerative Medicine Institute Jonathan Braun, MD, PhD Suzanne Devkota, PhD Phillip Fleshner, MD Gonsky Laboratory IBD Drug Discovery and Development Unit Inflammatory Bowel and Immunobiology Research Institute McGovern Laboratory Gil Melmed, MD Michelsen Laboratory MIRIAD IBD Biobank Precision Health Surgery Department Svendsen Laboratory Underhill Laboratory Reagent and Resources Advanced Inflammatory Bowel Disease Fellowship Biobehavioral Research Core Biostatistics & Bioinformatics Core Comparative Medicine Flow Cytometry Core Genomics Core Induced Pluripotent Stem Cell (iPSC) Core Research Compliance and Quality Improvement Research Informatics and Scientific Computing Core Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Targan Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome. Jacob N, Jacobs JP, Kumagai K, Ha CWY, Kanazawa Y, Lagishetty V, Altmayer K, Hamill AM, Von Arx A, Sartor RB, Devkota S, Braun J, Michelsen KS, Targan SR, Shih DQ. Muscosal Immunol. 2018 Sep;11(5):1466-1476. Enhanced utilization of induced pluripotent stem cell-derived human intestinal organoids using microengineered chips. Workman MJ, Gleeson JP, Troisi EJ, Estrada HQ, Kerns SJ, Hinojosa CD, Hamilton GA, Targan SR, Svendsen CN, Barrett RJ. Cell Mol Gastroenterol Hepatol. 2017 Dec 29;5(4):669-677.e2. Association of ribonuclease T2 gene polymorphisms with decreased expression and clinical characteristics of severity in Crohn’s disease. Gonsky R, Fleshner P, Deem RL, Biener-Ramanujan E, Li D, Potdar AA, Bilsborough J, Yang S, McGovern DPB, Targan SR. Gastroenterology. 2017 Jul;153(1):219-232. Contact the Targan Lab 110 N. George Burns Road Davis Building, Room D4063 Los Angeles, CA 90048 Lab 310-423-7723 Office 310-423-0537 Send A Message Please ensure Javascript is enabled for purposes of website accessibility