Publications - Svendsen Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Svendsen Lab Back to Svendsen Lab Lab Members Publications Research Areas Publications See a complete PubMed list of publications by Clive Svendsen, PhD. Selected Key Publications Laperle A, Sances S, Yucer N, Dardov V, Garcia V, Ho R, Fulton A, Roxas K, Avalos P, Shu Z, Murali R, Maidment NT, Van Eyk J, Tagliati M, Svendsen CN. An iPSC model of early onset sporadic Parkinson’s disease reveals predictive biomarkers and potential therapeutic candidates. Nature Medicine. 2020;26(2):289-299. Vatine G, Barrile R, Workman M, Sances S, Barriga B, Rhamana M, Barthakur S, Kasendra M, Lucchesi C, Kerns J, Wen N, Chen Z, Van Eyk J, Hamilton G, Svendsen CN. Human iPSC-derived blood brain barrier-chip for disease modeling and personalized medicine applications. Cell Stem Cell. 2019;24(6):995-1005.e6. Das M, Godoy M, Chen S, Avalos P, Dang I, Yáñez A, Zhang W, Bresee C, Liu G, Svendsen CN*, Goodridge H. Young bone marrow transplantation preserves learning and memory in old mice. Communications Biology. 2019;2:73 *Corresponding Author Thomsen G, Avalos P, Ma A, Alkaslasi M, Wyss L, Vit JP, Godoy M, Suezaki P, Shelest O, Bankiewicz, K, Svendsen CN. Transplantation of neural progenitor cells expressing GDNF into the motor cortex as a strategy to treat amyotrophic lateral sclerosis. Stem Cells. 2018;36(7):1122-1131. Akhtar A, Kobritz N, Savinoff S, Garcia L, Tom C, Shelley B, Cho N, Gowing G, Mattis V, Breunig J, Svendsen CN. Doxycycline-mediated inducible and reversible expression of GDNF in transplanted iPSC-derived neural progenitors. Stem Cell Reports. 2018;10(6): 1696-1704. Sances S, Ho R, Vatine G, West D, Laperle A, Meyer A, Godoy M, Kay P, Mandefro B, Matata S, Hinojsa C, Wen N, Sareen D, Hamilton G, Svendsen CN. Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development. Stem Cell Reports. 2018;10(4):1222-1236. Rushton D, Andres P, Allred P, Baloh R, Svendsen CN. Patients with ALS show highly correlated progression rates in left and right limb muscles. Neurology. 2017;89(2):196-206. Vatine G, Al-Ahmad A, Barriga B, Svendsen S, Salim A, Garcia L, Garcia V, Ho R, Yucer N, Qian T, Lim R, Wu J, Thompson L, Spivia W, Chen Z, Van Eyke J, Palecek S, Refetoff S, Shuster E, Svendsen CN. Modeling psychomotor retardation using iPSCs from MCT8-deficient patients indicates a prominent role for the blood-brain barrier. Cell Stem Cell. 2017;20(6): 831-843. Yucer N, Holzapfel M, Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan B, Svendsen CN. Directed differentiation of human induced pluripotent stem cells into fallopian tube epithelium. Scientific Reports. 2017;7(1):10741. Sances S, Bruijn LI, Chandran S, Eggan K, Ho R, Klim JR, Livesey MR, Lowry E, Macklis JD, Rushton D, Sadegh C, Sareen D, Wichterle H, Zhang SC, Svendsen CN. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nat Neurosci. 2016;16(4):542-553. Ho R, Sances S, Gowing G, Amoroso MW, O’Roarke JG, Shabian A, Wichterle H, Baloh RH, Sareen D, Svendsen CN. ALS disrupts spinal motor neuron maturation and aging pathways within gene co-expression networks. Nature Neurosci. 2016;19(9):1256-67. Das MM, Svendsen CN. Astrocytes show reduced support of motor neurons with aging that is accelerated in a rodent model of ALS. Neurobiol Aging. 2015;36(2):1130-1139. Thomsen GM, Gowing, Latter J, Chen M, Vit JP, Staggenborg K, Avalos P, Alkaslasi M, Ferraiuolo L, Likhite S, Kaspar BK, Svendsen CN. Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex. J Neurosci. 2014;34: 15587-600. Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate in the rodent spinal cord. J Comp Neurol. 2014;522: 2707-28. The Huntington’s Disease iPSC Consortium* Induced pluripotent stem cells from patients with Huntington's Disease show CAG repeat-associated phenotypes. Cell Stem Cell. 2012;11: 264-278 *Svendsen CN corresponding author. Ebert AD, Yu J, Rose F, Mattis VB, Lorson CL, Thomson JA, Svendsen CN. Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 2009;457: 277-280. Behrstock S, Ebert A, McHugh J, Vosberg S, Moore J, Schneider B, Capowski E, Hei D, Kordower J, Aebischer P, Svendsen CN. Human neural progenitors deliver glial cell line-derived neurotrophic factor to parkinsonian rodents and aged primates. Gene Ther. 2006;13: 379-88. Klein SM, Suzuki M, Behrstock S, McHugh J, Hoffmann K, Wallace W, Aebischer P, Svendsen CN. GDNF Delivery using human neural progenitor cells in a rat model of ALS. Human Gene Therapy. 2005;16: 509-21. Gill SS, Patel NK, Hotton GR, O'Sullivan K, McCarter R, Bunnage M, Brooks DJ, Svendsen CN*, Heywood P. Direct brain infusion of glial cell line-derived neurotrophic factor (GDNF) in Parkinson's Disease. Nature Medicine. 2003;9: 589-595. *Corresponding Author Sofroneiw MV, Galletely NP, Isacson O, Svendsen CN. Survival of adult basal forebrain cholingergic neurons after loss of target neurons. Science. 1990;247: 338-342. Contact the Svendsen Lab 127 S. San Vicente Blvd. Pavilion, Room 8405 Los Angeles, CA 90048 Office 310-248-8571 Lab 310-248-8573 Send A Message Please ensure Javascript is enabled for purposes of website accessibility