Sheyn Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Sheyn Lab The Sheyn Laboratory focuses on the development of stem cell therapies for multiple musculoskeletal disorders caused by acute injuries and aging. Using gene editing, biomechanical forces and specific transcription factors, the Sheyn Lab seeks to direct stem cells toward skeletal tissue-specific cell types to support healing and to reverse degenerative and inflammatory processes. Our close interaction with Cedars-Sinai orthopaedic surgeons and Biomedical Imaging Research Institute allows the Sheyn Laboratory to develop relevant animal models and to test the differentiated stem cell therapies in vivo. The Sheyn Laboratory is affiliated with the Cedars-Sinai Board of Governors Regenerative Medicine Institute and Orthopaedics, Surgery, and the Department of Biomedical Sciences. To make a gift to the Sheyn Lab, use the link below and select "Other" in the "Designation" drop-down menu. Type in "Sheyn Lab" in the "Other" field. Make a Gift: Support Sheyn Lab Personal Statement I have devoted more than 15 years to the research of gene and stem cell therapies. This field holds great therapeutic potential. In my postdoctoral work, I developed an efficient and easily reproducible method to modify stem cells and to regenerate bone defects. The cell therapy approach was tested and found biomechanically valid and new bone tissue was comparable to the native bone." Dmitriy Sheyn, PhD Breakthrough Research Areas Intervertebral Disc Regeneration—Making the Intervertebral Disc Young Again Challenging Dogmas and Developing New Treatments in Sports Medicine Revitalization of Allografts—Bringing New Life to Dead Bone Grafts for Craniofacial Injuries Collaborations Internal Breunig Laboratory Di Vizio Laboratory Ho Laboratory Li Laboratory Orr Limpisvasti, MD Kerlan-Jobe Institute Bert R. Mandelbaum, MD, Kerlan-Jobe Institute Jon Mallen-St. Clair, MD, PhD Metzger Laboratory Thomas J. Kremen, MD Tiffanny G. Perry, MD Sang Do Kim, MD, MS External Denis Evseenko, MD, PhD, University of Southern California Karen Lyons, PhD Dror Seliktar, PhD, Technion Israel Jess Gerrit Snedeker, PhD, University of Zurich, Switzerland Laura S. Stone, PhD, University of Minnesota Mehmet R. Dokmeci, Associate Professor Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Sheyn Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Open Positions Graduate Student To apply for PhD studies in the Sheyn Lab, apply for admission to the graduate program in the Department of Biomedical Sciences and choose Dmitriy Sheyn, PhD, as your research rotation adviser. Apply Now Research Intern The Sheyn Laboratory invites students to gain hands-on experience. The research intern will be instructed in lab safety and sterile techniques and trained to perform wet-lab techniques and image analysis. Apply Now Postdoctoral Scientist The Sheyn Laboratory has a current opening for a Postdoctoral Scientist. This position will focus on IVD regeneration and stem cell differentiation projects. Apply Now Publications Single-cell atlas unveils cellular heterogeneity and novel markers in human neonatal and adult intervertebral discs. Jiang W, Glaeser JD, Salehi K, Kaneda G, Mathkar P, Wagner A, Ho R, Sheyn D. iScience. 2022 Jun 2;25(7):104504. Neural crest-derived mesenchymal progenitor cells enhance cranial allograft integration. Glaeser JD, Behrens P, Stefanovic T, Salehi K, Papalamprou A, Tawackoli W, Metzger MF, Eberlein S, Nelson T, Arabi Y, Kim K, Baloh RH, Ben-David S, Cohn-Schwartz D, Ryu R, Bae HW, Gazit Z, Sheyn D. Stem Cells Transl Med. 2021 May;10(5):797-809. Assessing the Resident Progenitor Cell Population and the Vascularity of the Adult Human Meniscus. Chahla J, Papalamprou A, Chan V, Arabi Y, Salehi K, Nelson TJ, Limpisvasti O, Mandelbaum BR, Tawackoli W, Metzger MF, Sheyn D. Arthroscopy. 2021 Jan;37(1):252-265. A Translational Porcine Model for Human Cell-Based Therapies in the Treatment of Posttraumatic Osteoarthritis After Anterior Cruciate Ligament Injury. Kremen TJ Jr, Stefanovic T, Tawackoli W, Salehi K, Avalos P, Reichel D, Perez MJ, Glaeser JD, Sheyn D. Am J Sports Med. 2020 Oct;48(12):3002-3012. Contact the Sheyn Lab 127 S. San Vicente Blvd. Advanced Health Sciences Pavilion, A8308 Los Angeles, CA 90048 424-315-4579 Send A Message Please ensure Javascript is enabled for purposes of website accessibility