Publications - Seki Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Seki Lab Back to Seki Lab Lab Members Personal Statement Publications Research Areas Publications See a complete PubMed list of publications by Ekihiro Seki, MD, PhD. Selected Key Publications Oral administration of PEGylated TLR7 ligand ameliorates alcohol-associated liver disease via the induction of IL-22. Wang Q, Kim SY, Matsushita H, Wang Z, Pandyarajan V, Matsuda M, Ohashi K, Tsuchiya T, Roh YS, Kiani C, Zhao Y, Chan M, Devkota S, Lu SC, Hayashi T, Carson DA, Seki E., Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2020868118. PMID:33443222 Hyaluronan synthase 2-mediated hyaluronan production mediates Notch1 activation and liver fibrosis. Yang YM, Noureddin M, Liu C, Ohashi K, Kim SY, Ramnath D, Powell EE, Sweet MJ, Roh YS, Hsin IF, Deng N, Liu Z, Liang J, Mena E, Shouhed D, Schwabe RF, Jiang D, Lu SC, Noble PW, Seki E. Sci Transl Med. 2019 Jun 12;11(496). pii: eaat9284. doi: 10.1126/scitranslmed.aat9284. PMID: 31189722 NOD-like receptor C4 Inflammasome Regulates the Growth of Colon Cancer Liver Metastasis in NAFLD. Ohashi K, Wang Z, Yang YM, Billet S, Tu W, Pimienta M, Cassel SL, Pandol SJ, Lu SC, Sutterwala FS, Bhowmick N, Seki E. Hepatology. 2019 Nov;70(5):1582-1599. doi: 10.1002/hep.30693. Epub 2019 May 23. PMID: 31044438 Murine macrophage autophagy protects against alcohol-induced liver injury by degrading interferon regulatory factor 1 (IRF1) and removing damaged mitochondria. Liang S, Zhong Z, Kim SY, Uchiyama R, Roh YS, Matsushita H, Gottlieb RA, Seki E. J Biol Chem. 2019 Aug 16;294(33):12359-12369. doi: 10.1074/jbc.RA119.007409. Epub 2019 Jun 24. PMID: 31235522 Neurotropin Inhibits Lipid Accumulation by Maintaining Mitochondrial Function in Hepatocytes via AMPK Activation. Wang Q, Wang Z, Xu M, Tu W, Hsin IF, Stotland A, Kim JH, Liu P, Naiki M, Gottlieb RA, Seki E. Front Physiol. 2020 Aug 6;11:950. doi: 10.3389/fphys.2020.00950. PMID: 32848877 TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis. Inokuchi-Shimizu S, Park EJ, Roh YS, Yang L, Zhang B, Song J, Liang S, Pimienta M, Taniguchi K, Wu X, Asahina K, Lagakos W, Mackey MR, Akira S, Ellisman MH, Sears DD, Olefsky JM, Karin M, Brenner DA, Seki E. J Clin Invest. 2014 Aug;124(8):3566-78. doi: 10.1172/JCI74068. Epub 2014 Jul 1. PMID: 24983318 Transforming growth factor-β signaling in hepatocytes promotes hepatic fibrosis and carcinogenesis in mice with hepatocyte-specific deletion of TAK1. Yang L, Inokuchi S, Roh YS, Song J, Loomba R, Park EJ, Seki E. Gastroenterology. 2013 May;144(5):1042-1054.e4. doi: 10.1053/j.gastro.2013.01.056. Epub 2013 Feb 4. PMID: 23391818 Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Inokuchi S, Aoyama T, Miura K, Osterreicher CH, Kodama Y, Miyai K, Akira S, Brenner DA, Seki E. Proc Natl Acad Sci U S A. 2010 Jan 12;107(2):844-9.doi: 10.1073/pnas.0909781107. Epub 2009 Dec 18. PMID:20080763 CCR1 and CCR5 promote hepatic fibrosis in mice. Seki E, De Minicis S, Gwak GY, Kluwe J, Inokuchi S, Bursill CA, Llovet JM, Brenner DA, Schwabe RF. J Clin Invest. 2009 Jul;119(7):1858-70.. PMID: 19603542 TLR4 enhances TGF-beta signaling and hepatic fibrosis. Seki E, De Minicis S, Osterreicher CH, Kluwe J, Osawa Y, Brenner DA, Schwabe RF. Nat Med. 2007 Nov;13(11):1324-32. Epub 2007 Oct 21. PMID: 17952090 Contact the Seki Lab 8700 Beverly Blvd. Davis Building, Rooms 2099, 2029 Los Angeles, CA 90048 310-423-6605 Send A Message Please ensure Javascript is enabled for purposes of website accessibility