Publications - Sareen Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Sareen Lab Back to Sareen Lab Lab Members Personal Statement Publications Research Areas Publications See a complete PubMed list of publications by Dhruv Sareen, PhD. Selected Key Publications Rajamani U, Gross AR, Hjelm BE, Sequeira A, Vawter MP, Tang J, Gangalapudi V, Wang Y, Andres AM, Gottlieb RA, Sareen D. Super-obese patient-derived iPSC hypothalamic neurons exhibit obesogenic signatures and hormone responses. Cell Stem Cell. 2018 May 3;22(5):698-712. https://www.sciencedirect.com/science/article/pii/S1934590918301152. Sances S, Ho R, Vatine G, West D, Laperle A, Myeyr A, Godoy M, Kay PS, Mandefro B, Hatata S, Hinojosa C, Wen N, Sareen D, et al. Human iPSC-derived endothelial cells and microengineered organ-chip enhance neuronal development. Stem Cell Reports. 2018 Apr 10;10(4):1222-1236. https://www.sciencedirect.com/science/article/pii/S2213671118301036. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, […], Sareen D, et al. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-level cataloging of human cells response to perturbations. Cell Syst. 2018 Jan 24;6(1)13-24. https://www.cell.com/cell-systems/fulltext/S2405-4712(17)30490-8. Xiong Y, Soumillon M, Wu J, Hansen J, Hu B, van Hasselt JGC Janaraman G, Lim RA, Bouhaddou M, Ornelas L, Bochicchio J, Lenaeus L, Stocksdale J, Shim J, Gomez E, Sareen D, et al. A comparison of mRNA sequencing with random primed and 3'-directed libraries. Sci Rep. 2017 Nov 7;7(1):14626. https://www.nature.com/articles/s41598-017-14892-x. Yucer N, Holzapfel M, Jenkins Vogel T, Lenaeus L, Ornelas L, Laury A, Sareen D, Barrett R, Karlan BY, Svendsen CN. Directed differentiation of human induced pluripotent stem Cells into fallopian tube epithelium. Sci Rep. 2017 Sep 6;7(1):10741. https://www.nature.com/articles/s41598-017-05519-2. Rajamani U, Gross AR, Ocampo C, Andres AM, Gottlieb RA, Sareen D. Endocrine disruptors induce perturbations in endoplasmic reticulum and mitochondria of human pluripotent stem cell derivatives. Nat Commun. 2017 Aug 9;8(1):219. https://www.nature.com/articles/s41467-017-00254-8. Fuller HR, Mandefro B, Shirran SL, Gross AR, Kaus AS, Botting CH, Morris GE, Sareen D. Spinal muscular atrophy patient iPSC-derived motor neurons have reduced expression of proteins important in neuronal development. Front Cell Neurosci. 2016 Jan 11. http://journal.frontiersin.org/article/10.3389/fncel.2015.00506/full. Hatada S, Subramanian A, Mandefro B, Ren S, Kim HW, Tang J, Funari V, Sareen D, Arumugaswami V, Svendsen C. Low-dose irradiation enhances gene targeting in human pluripotent stem cells. Stem Cells Transl Med. 2015;4(9):998-1010. http://stemcellstm.alphamedpress.org/content/4/9/998.long. Tsai Y, Lu B, Bakondi B, Girman S, Sahabian A, Sareen D, Svendsen CN, Wang S. Human iPSC-derived neural progenitors preserve vision in an AMD-like model. Stem Cells. 2015;33(8):2537-2549. http://onlinelibrary.wiley.com/doi/10.1002/stem.2032/abstract. Mattis VB, Tom C, Akimov, S, Saeedian J, Østergaard ME, Southwell AL, Doty CN, Ornelas L, Sahabian A, Lenaeus L, Mandefro B, Sareen D, et al. HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity. Hum Mol Genet. 2015;24(11):3257-3271. https://academic.oup.com/hmg/article/24/11/3257/721491 Ren S, Irudayam JI, Contreras D, Sareen D, Talavera-Adame, Svendsen CN, Arumugaswami V. Bioartificial liver device based on induced pluripotent stem cell-derived hepatocytes. J Stem Cell Res Ther. 2015;5(2):263. http://www.omicsonline.org/open-access/bioartificial-liver-device-based-on-induced-pluripotent-stem-cellderived-hepatocytes-2157-7633.1000263.php?aid=39553. Kaus A, Sareen D. ALS patient stem cells for unveiling disease signatures of motoneuron susceptibility: perspectives on the deadly mitochondria, ER stress and calcium triad. Front Cell Neurosci. 2015 Nov 19;9:448. http://journal.frontiersin.org/article/10.3389/fncel.2015.00448/abstract. Barrett R, Ornelas L, Yeager N, Mandefro B, Sahabian A, Lenaeus L, Targan SR, Svendsen CN, Sareen D. Reliable generation of induced pluripotent stem cells from human lymphoblastoid cell lines. Stem Cell Transl Med. 2014;3(12):1429-1434. http://stemcellstm.alphamedpress.org/content/3/12/1429. Sareen D, Saghizadeh M, Ornelas L, Winkler MA, Narwani K, Sahabian A, Funari VA, Tang J, Spurka L, Punj V, et al. Differentiation of human limbal-derived induced pluripotent stem cells into limbal-like epithelium. Stem Cells Transl Med. 2014 Sep;3(9):1002-1012. http://stemcellstm.alphamedpress.org/content/3/9/1002. Josson S, Gururajan M, Hu P, Shao C, Chu GY, Zhau HE, Liu C, Lao K, Lu CL, Lu YT, Lichterman J, Nandana S, Li Q, Rogatko A, Berel D, Posadas EM, Fazli L, Sareen D, Chung LW. miR-409-3p/-5p promotes tumorigenesis, epithelial-to-mesenchymal transition, and bone metastasis of human prostate cancer. Clin Cancer Res. 2014 Sep 1;20(17):4636-4646. https://aacrjournals.org/clincancerres/article/20/17/4636/13305/miR-409-3p-5p-Promotes-Tumorigenesis-Epithelial-to Sareen D, Gowing G, Sahabian A, Staggenborg K, Paradis R, Avalos P, Latter J, Ornelas L, Garcia L, Svendsen CN. Human induced pluripotent stem cells are a novel source of neural progenitor cells (iNPCs) that migrate and integrate in the rodent spinal cord. J Comp Neurol. 2014 Aug 15;522(12):2707-2728. http://onlinelibrary.wiley.com/doi/10.1002/cne.23578/abstract;jsessionid=8692106E71B8DCF546353110BB69A2BA.f04t03. Saitta B, Passarini J, Sareen D, Ornelas L, Sahabian A, Argade S, Krakow D, Cohn DH, Svendsen CN, Rimoin DL. Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1. Stem Cells Dev. 2014 Jul 1; 23(13):1464-1478. http://online.liebertpub.com/doi/abs/10.1089/scd.2014.0014. Mattis VB, Wakeman DR, Colton T, Dodiya HB, Yeung SY, Tran AH, Bernau K, Ornelas L, Sahabian A, Reidling J, Sareen D, et al. Neonatal immune-tolerance in mice does not prevent xenograft rejection. Exp Neurol. 2014 Apr;254:90-98. http://dx.doi.org/10.1016/j.expneurol.2014.01.007. Sareen D, O’Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Sci Transl Med. 2013 Oct 23;5(208):208ra149. http://stm.sciencemag.org/content/5/208/208ra149. Ebert AD, Shelley BC, Hurley AM, Onorati M, Castiglioni V, Patitucci TN, Svendsen SP, Mattis VB, McGivern JV, Schwab AJ, Sareen D, et al. EZ spheres: a stable and expandable culture system for the generation of pre-rosette multipotent stem cells from human ESCs and iPSCs. Stem Cell Res. 2013 May;10(3):417-427. http://www.sciencedirect.com/science/article/pii/S1873506113000160. Sareen D, Ebert AD, Heins BM, McGivern JV, Ornelas L, Svendsen CN. Inhibition of apoptosis blocks human motor neuron cell death in a stem cell model of spinal muscular atrophy. PLOS One. 2012;7(6):e39113. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0039113. Contact the Sareen Lab 8687 Melrose Ave., Suite B227 West Hollywood, CA 90069 Send A Message Please ensure Javascript is enabled for purposes of website accessibility