Saghizadeh Ghiam Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Saghizadeh Ghiam Lab Under the direction of Mehrnoosh Saghizadeh Ghiam, PhD, associate professor of Biomedical Sciences at the Cedars-Sinai Board of Governors Regenerative Medicine Institute Eye Program, the Saghizadeh Ghiam Laboratory is focused on identifying specific molecular corneal defects associated with corneal pathological conditions, such as diabetes. The goal of the Saghizadeh Ghiam Lab is to understand the roles of microRNAs in both the differentiated epithelial and stem cells of normal and diabetic corneas as well as their roles in driving peripheral activation of limbal stem cells in normal and diseased corneas. The laboratory also investigates the major mechanisms of action of nanosized limbal extracellular vesicles (EVs), which are taken up by neighboring cells, in stem cell maintenance and wound repair in cell cultures and in human organ-cultured corneas. In addition, the Saghizadeh Ghiam Lab investigates the therapeutic potential of EVs for treatment of corneal injuries and diabetic abnormalities. The ultimate goal of the lab is to restore stem cell function for future clinical translation. The Saghizadeh Ghiam Laboratory is affiliated with Cedars-Sinai Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences and Eye Program. Personal Statement I am an associate professor in the Board of Governors Regenerative Medicine Institute Eye Program in the Department of Biomedical Sciences at Cedars-Sinai. I am also an adjunct assistant professor at the David Geffen School of Medicine at UCLA." Mehrnoosh Ghiam, PhD Breakthrough Research Areas Researchers in the Saghizadeh Ghiam Laboratory study the microRNA regulatory mechanisms of limbal epithelial stem cell (LESC) proliferation, migration, adhesion and differentiation in normal cornea homeostasis and wound-healing processes. Understanding these mechanisms could be key to understanding corneal diseases. In addition, the Saghizadeh Ghiam Lab studies the contribution of limbal extracellular vesicles (EVs) derived from corneal epithelial (LECs) and stromal cells in the molecular processes that lead to regeneration and wound healing. Collaborations Van Eyk Laboratory S. Wang Laboratory Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Ghiam Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Exosomes from normal and diabetic human corneolimbal keratocytes differentially regulate migration, proliferation and marker expression of limbal epithelial cells. Leszczynska A, Kulkarni M, Ljubimov AV, Saghizadeh M. Sci Rep. 2018 Oct 11;8(1):15173. Stem cell for corneal wound healing. Saghizadeh M, Kramerov AA, Svendsen CN, Ljubimov AV. Stem Cells. 2017 Oct;35(10):2105-2114. Genome-wide analysis suggests a differential microRNA signature associated with normal and diabetic human cornal limbus. Kulkarni M, Leszczynska A, Wei G, Winkler MA, Tang J, Funari VA, Deng N, Liu Z, Punj V, Deng SX, Ljubimov AV, Saghizadeh M. Sci Rep. 2017 Jun 14;7(1):3448. Contact the Saghizadeh Ghiam Lab Advanced Health Sciences Pavilion, Suite A8104 127 S. San Vicente Blvd. Los Angeles, CA 90048 310-248-8696 Send a Message Please ensure Javascript is enabled for purposes of website accessibility