Publications - Lu Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Lu Laboratory Back to Lu Laboratory Lab Members Personal Statement Publications Research Areas Publications See a complete PubMed list of publications by Shelly Lu, MD Selected Key Publications Yang JW, Murray B, Barbier-Torres L, Liu T, Liu Z, Yang H, Fan W, Wang J, Li Y, Seki E, Mato JM, Lu SC. The mitochondrial chaperone Prohibitin 1 negatively regulates interleukin-8 in human liver cancers. J Biol Chem. 2018 Dec 6. pii: jbc.RA118.004863. http://www.jbc.org/content/early/2018/12/06/jbc.RA118.004863. Liu T, Yang H, Fan W, Tu J, Li TWH, Wang J, Shen H, Yang J, Xiong T, Steggerda J, Liu Z, Noureddin M, Maldonado SS, Annamalai A, Seki E, Mato JM, Lu SC. Mechanisms of MAFG dysregulation in cholestatic liver injury and development of liver cancer. Gastroenterology. 2018 Aug;155(2):557-571.e14. https://www.sciencedirect.com/science/article/pii/S0016508518344822. Fan W, Yang H, Liu T, Wang J, Li TW, Mavila N, Tang Y, Yang J, Peng H, Tu J, Annamalai A, Noureddin M, Krishnan A,Gores GJ, Martínez-Chantar ML, Mato JM, Lu SC. Prohibitin 1 suppresses liver cancers tumorigenesis in mice and humans. Hepatology. 2017 Apr;65(4):1249-1266. https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.28964. Alonso C, Fernández-Ramos D, Varela-Rey M, Martínez-Arranz I, Navasa N, Van Liempd SM, Lavín Trueba JL, Mayo R, Ilisso CP, de Juan VG, Iruarrizaga-Lejarreta M, delaCruz-Villar L, Mincholé I, Robinson A, Crespo J, Martín-Duce A, Romero-Gómez M, Sann H, Platon J, Van Eyk J, Aspichueta P, Noureddin M, Falcón-Pérez JM, Anguita J, Aransay AM, Martínez-Chantar ML, Lu SC, Mato JM. Metabolic identification of subtypes of nonalcoholic steatohepatitis. Gastroenterology. 2017 May;152(6):1449-1461.e7. https://www.sciencedirect.com/science/article/pii/S0016508517300720. Yang H, Liu T, Wang J, Li TW, Fan W, Peng H, Krishnan A, Gores GJ, Mato JM, Lu SC. Deregulated methionine adenosyltransferase α1, c-Myc and Maf proteins together promote cholangiocarcinoma growth in mice and humans. Hepatology.2016 Aug;64(2):439-455. https://aasldpubs.onlinelibrary.wiley.com/doi/full/10.1002/hep.28541. Ramani K, Mavila N, Ko KS, Mato JM, Lu SC. Prohibitin 1 regulates the H19-Igf2 axis and proliferation in hepatocytes. J Biol Chem.2016 Nov 11;291(46):24148-24159. http://www.jbc.org/content/291/46/24148.long. Yang H, Li TW, Zhou Y, Peng H, Liu T, Zandi E, Martínez-Chantar ML, Mato JM, Lu SC. Activation of a novel c-Myc-miR27-prohibitin 1 circuitry in cholestatic liver injury inhibits glutathione synthesis in mice. Antioxid Redox Signal. 2015 Jan 20;22(3):259-274. http://online.liebertpub.com/doi/abs/10.1089/ars.2014.6027. Peng H, Dara L, Li TW, Zheng Y, Yang H, Tomasi ML, Tomasi I, Giordano P, Mato JM, Lu SC. MAT2B-GIT1 interplay activates MEK1/ERK 1 and 2 to induce growth in human liver and colon cancer. Hepatology. 2013 Jun;57(6):2299-2313. http://onlinelibrary.wiley.com/doi/10.1002/hep.26258/full. Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013 May;1830(5):3143-3153. https://www.sciencedirect.com/science/article/pii/S0304416512002632. Yang H, Cho ME, Li TW, Peng H, Ko KS, Mato JM, Lu SC. MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma. J Clin Invest. 2013 Jan;123(1):285-298. http://www.jci.org/articles/view/63861. Lu SC, Mato JM. S-adenosylmethionine in liver health, injury and cancer. Physiol Rev. 2012 Oct;92(4):1515-1542.https://www.physiology.org/doi/full/10.1152/physrev.00047.2011. Tomasi ML, Iglesias Ara A, Yang H, Ramani K, Feo F, Pascale MR, Martínez-Chantar ML, Mato JM, Lu SC. S-adenosylmethionine regulates apurinic/apyrimidinic endonuclease 1 stability: implication in hepatocarcinogenesis. Gastroenterology. 2009;136(3):1025-1036. http://www.gastrojournal.org/article/S0016-5085(08)01695-8/abstract. Yang H, Iglesias Ara A, Magilnick N, Xia M, Ramani K, Chen H, Lee TD, Mato JM, Lu SC. Expression pattern, regulation and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells. Gastroenterology. 2008;134(1):281-291. http://www.gastrojournal.org/article/S0016-5085(07)01853-7/abstract. Chen H, Xia M, Lin M, Yang H, Kuhlenkamp J, Li T, Sodir NM, Chen YH, Josef-Lenz H, Laird PW, Clarke S, Mato JM, Lu SC. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. Gastroenterology. 2007;133(1):207-218. http://www.gastrojournal.org/article/S0016-5085(07)00640-3/abstract. Lu SC, Alvarez L, Huang ZZ, Chen L, An W, Corrales FJ, Avila MA, Kanel G, Mato JM. Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Nat Acad Sci USA. 2001;98(10):5560-5565. http://www.pnas.org/content/98/10/5560.abstract. Please ensure Javascript is enabled for purposes of website accessibility