Knott Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Knott Lab The goal of the Knott Laboratory is to develop cancer treatment strategies that are focused on the hetero-cellular interactions within tumors that drive disease progression. This work entails developing and interrogating models of resistance to already established as well as experimental therapies. In addition, the Knott Lab applies novel profiling methods to study patient tumors so that the cellular interactions driving the diseased tissue can be ascertained. By applying the knowledge gained from studying clinical material to focus questions asked of the model systems, the Knott Lab hopes to identify rationally guided therapeutic strategies to halt disease progression. The Knott Laboratory is affiliated with the Cedars-Sinai Department of Biomedical Sciences. Personal Statement I am an assistant professor and associate director of the Center for Bioinformatics and Functional Genomics at Cedars-Sinai. My laboratory is focused on understanding the mechanisms that cancer cells use to evade standard of care and experimental therapies. This entails developing and analyzing mouse models of drug resistance as well as profiling patient tumor material to identify cellular pathways that are amplified in response to the therapeutic onslaught." Simon Knott, PhD Breakthrough Research Areas The Knott Laboratory is interested in a variety of research topics. The lab currently has three main areas of focus: Tumor Heterogeneity, Hetero-Cellular Interactions in Tumors and Technology Development. Collaborations Berman Laboratory Center for Bioinformatics and Functional Genomics Gayther Laboratory Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Knott Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Asparagine bioavailability governs metastasis in a model of breast cancer. Knott SRV, Wagenblast E, Khan S, Kim SY, Soto M, Wagner M, Turgeon MO, Fish L, Erard N, Gable AL, et al. Nature. 2018 Feb 15;554(7692):378-381. A CRISPR resource for individual, combinatorial, or multiplexed gene knockout. Erard N, Knott SRV, Hannon GJ. Mol Cell. 2017 July 20;67(2)348-354. A model of breast cancer heterogeneity reveals vascular mimicry as a driver of metastasis. Wagenblast E, Soto M, Gutiérrez-Ángel S, Hartl CA, Gable AL, Maceli AR, Erard N, Williams AM, Kim SY, Dickopf S, Harrell CJ, Smith AD, Perou CM, Wilkinson JE, Hannon GJ, Knott SR. Nature. 2015 Apr 16;520(7547):358-362. Contact the Knott Lab 8700 Beverly Blvd. Steven Spielberg Building, Suite 100 Los Angeles, CA 90048 310-423-7664 Send a Message Please ensure Javascript is enabled for purposes of website accessibility