Jefferies Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Jefferies Lab The Jefferies Laboratory is focused on understanding the role that RNA/DNA sensing mechanisms in monocytes and neutrophils play in driving autoimmune disease. The lab’s main area of focus is understanding these pathways in lupus, a debilitating, chronic autoimmune disease that presents as a broad spectrum of symptoms and manifestations. Patients with lupus have increased expression of interferon-stimulated genes (ISGs), a signature that correlates directly with disease activity. A feature of lupus is that women are more likely to get the disease; therefore, the Jefferies Lab is also studying how estrogen and steroid hormones affect these pathways. The Jefferies Laboratory is affiliated with the Cedars-Sinai Department of Medicine, Department of Biomedical Sciences and Rheumatology. Personal Statement My goal is to uncover the fundamental mechanisms that lead to the development of lupus and discover ways to use this knowledge to better treat and manage this debilitating disease. To achieve this, I have focused on establishing strong working collaborations with leading rheumatologists, both in the U.S. and Ireland who specialize in lupus research. Caroline Jefferies, PhD Breakthrough Research Areas Understanding the Interferon Signaling Pathway in Lupus Neutrophils Investigating Crosstalk Among Estrogen, RNA/DNA Sensing and IFN in the Immune Response in SLE Neutrophils, Endoplasmic Reticulum Stress and Lung Disease CREWHS Call for Applications The Center for Research in Women’s Health and Sex Differences (CREWHS) is calling for investigators to submit their research on women’s health or sex differences. Winners of the award will receive up to $50,000 (direct costs) for a year with a potential to extend for a second year. The funded research will be highlighted at the 4th Annual CREWHS Symposium on October 28, 2022. Please submit your research application via email at [email protected] by 5:00 p.m. on Friday, April 8, 2022. Winners will be notified on Friday, May 27, 2022. LEARN MORE Internal Collaborations Department of Medicine Immunology & Infectious Diseases Research Lung Institute Rheumatology Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Jefferies Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications MicroRNA-302d targets IRF9 to regulate the IFN-induced gene expression in SLE. Smith S, Fernando T, Wu PW, Seo J, Ní Gabhann J, Piskareva O, McCarthy E, Howard D, O’Connell P, Conway R, Gallagher P, Molloy E, Stallings RL, Kearns G, Forbess L, Ishimori M, Venuturupalli S, Wallace D, Weisman M, Jefferies CA. J Autoimmun. 2017 May;79:105-111. The association of cytokines with disease activity and damage scores in systemic lupus erythematosus patients. McCarthy EM, Smith S, Lee RZ, Cunnane G, Doran MF, Donnelly S, Howard D, O'Connell P, Kearns G, Ní Gabhann J, Jefferies CA. Rheumatology (Oxford). 2014 Sep;53(9):1586-1594. Btk regulates macrophage polarization in response to lipopolysaccharide. Ní Gabhann J, Hams E, Smith S, Wynne C, Byrne JC, Brennan K, Spence S, Kissenpfennig A, Johnston JA, Fallon PG, Jefferies CA. PLOS ONE. 2014 Jan 21;9(1):e85834. Contact the Jefferies Lab 8700 Beverly Blvd. Davis Building, Room 5094E Los Angeles, CA 90048 310-423-8658 Fax:310-423-6898 Send a Message Please ensure Javascript is enabled for purposes of website accessibility