Goodridge Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Goodridge Lab Myeloid Cell Differentiation and Function Hematopoietic stem cells (HSCs) give rise to all the different types of blood cells, including myeloid phagocytes (neutrophils, monocytes, macrophages and dendritic cells). Myeloid phagocytes are immune cells that defend the body against invading microbes, and also play important roles in inflammatory diseases, aging and cancer. The Goodridge Laboratory is studying the development (a process known as myelopoiesis) and function of myeloid phagocytes. The Goodridge Laboratory is affiliated with the Cedars-Sinai Board of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Immunology & Infectious Diseases Research, Department of Medicine, F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute and Samuel Oschin Comprehensive Cancer Institute. The lab has received funding from the National Institutes of Health, American Heart Association, American Association of Immunologists, American Society of Hematology, and Cedars-Sinai (Board of Governors Regenerative Medicine Institute and Samuel Oschin Comprehensive Cancer Institute). Personal Statement The Goodridge Laboratory studies include pathways and mechanisms of myelopoiesis during homeostasis and in response to infections and tumors. My lab also has interests in the roles of hematopoietic cells in tissue aging and neurodegenerative disease, as well as the use of induced pluripotent stem cell-derived myeloid cells to study and treat human disease. Helen Goodridge, PhD Breakthrough Research Areas The Goodridge Laboratory studies the development and function of neutrophils, monocytes, macrophages and dendritic cells. These innate immune cells play key roles in anti-microbial defense and inflammation, as well as in tissue development, repair and regeneration. Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Goodridge Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View our team Job Openings The Goodridge Laboratory has an open position for a postdoc. To apply, please send a description of your interests together with your curriculum vitae to [email protected] or apply online for the Postdoctoral Scientist - Goodridge Lab position. APPLY NOW Publications Young bone marrow transplantation preserves learning and memory in old mice. Das MM, Godoy M, Chen S, Moser VA, Avalos P, Roxas KM, Dang I, Yáñez A, Zhang W, Bresee C, Arditi M, Liu GY, Svendsen CN*, Goodridge HS*. Commun Biol. 2019; 2:73. IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production. Yáñez A, Ng MY, Hassanzadeh-Kiabi N, Goodridge HS. Blood. 2015 Feb 26;125(9):1452-1459. Granulocyte-Monocyte Progenitors and Monocyte-Dendritic Cell Progenitors Independently Produce Functionally Distinct Monocytes. Yáñez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL, Goodridge HS. Immunity. 2017 Nov 21; 47(5):890-902. Collaborations Arditi Laboratory Berman Laboratory Bernstein Laboratory Shuang Chen, MD, PhD Gottlieb Laboratory Hazelett Laboratory Knott Laboratory Martins Laboratory Noah Merin, MD, PhD Riera Laboratory Svendsen Laboratory Underhill Laboratory Contact the Goodridge Lab 8700 Beverly Blvd. Advanced Health Sciences Pavilion, Eighth Floor Los Angeles, CA 90048 Office 310-248-8577 Lab 310-248-8559 Send a Message Please ensure Javascript is enabled for purposes of website accessibility