Fert-Bober Laboratory Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Fert-Bober Lab The Fert-Bober Laboratory uses mass spectrometry to study proteins and post-translational modifications that are altered with disease state, particularly in cardiovascular diseases. We interrogate a variety of complex sample types including tissue, serum/plasma, cells and proximal fluids. The Fert-Bober Lab develops and applies methods to clinical samples with the goal of improving early detection of hypertrophic cardiomyopathy by understanding the underlying molecular and biological pathways, including how immune response is affected by disease. We also develop and apply methods to study the protein post-translational modification citrullination in a variety of sample types to better understand and exploit the role of citrullinated proteins in physiological and pathological conditions. These advances would not be possible without a collaborative research environment in which individuals are encouraged to pursue their own high-risk, high-reward ideas. The Fert-Bober Laboratory is affiliated with the Cedars-Sinai Smidt Heart Institute and the Advanced Clinical Biosystems Research Institute. Personal Statement Being able to quantify proteins and their post-translational modifications (PTMs), together with neo-epitope generation driven by PTM is my lab goal in the near future. Each modification results from a specific local physiological or pathobiological process. Identification of each modification, and the affected tissue-specific protein, may produce a unique disease-specific biochemical marker. Particularly, PTM, called citrullination and neo-epitopes to citrullinated sites in recent years have become increasingly appreciated. Our central philosophy is that such neo-epitopes can be utilized in translational medicine to estimate safety and efficacy in both preclinical models and clinical settings." Justyna Fert-Bober, PhD Breakthrough Research Areas Essential Cross-Talk Between Cardiomyocytes, Fibroblasts and Inflammatory Cells Through Citrullinoproteome Modulation New Markers for Pathogenesis of Ischemic and Nonischemic Heart Diseases in Rheumatoid Arthritis Mechanisms Underlying the Atherosclerosis Plaque Development Collaborations Internal Erbay Laboratory Koronyo-Hamaoui Laboratory Van Eyk Laboratory External David M. Herrington, MD, PhD, Wake Forest School of Medicine, Cardiology Joan M. Bathon, MD, Columbia University Department of Medicine, Division of Rheumatology Felipe A. Andrade, MD, PhD, Johns Hopkins Medicine Meet Our Team Our shared passion is to decipher the role of protein arginine deiminases and citrullinated proteins within physiological and pathological conditions using advanced mass spectrometry encompassing molecular and cellular biology. We celebrate our different backgrounds and strengths, help each other with our weaknesses and together we create an environment of lively interaction and mutual respect. View Our Team Job Opportunities The candidate will investigate whether citrullinated proteins or antibodies to citrullinated proteins can be used as biomarkers for the early detection of many diseases, including rheumatoid arthritis, cancer and Alzheimer's disease. Postdoctoral Scientist The Fert-Bober Laboratory has a current opening for a Postdoctoral Scientist. This position will investigate molecular mechanisms of cardiovascular development, regeneration and cardiac fibrosis using mass spectrometric-based proteomics methods for the study of proteins and their roles in cellular signaling events. Apply Now Research Associate I The Fert-Bober Laboratory has a current opening for a Research Associate I. The position will pursue cutting-edge research pertaining to cellular and molecular mechanisms from inflammation to fibrosis in various cardiac disease with primary focus on post-translational modification, citrullination. Apply Now Publications Insights into the study and origin of the citrullinome in rheumatoid arthritis. Fert-Bober J, Darrah E, Andrade F. Immunol Rev. 2020 Mar;294(1):133-147. Mapping citrullinated sites in multiple organs of mice using hyper-citrullinated library. Fert-Bober J, Venkatraman V, Hunter CL, Liu R, Crowgey EL, Pandey R, Holewinski RJ, Stotland A, Berman BP, Van Eyk JE. J Proteome Res. 2019 May 3;18(5):2270-2278. Association of anti-citrullinated protein or peptide antibodies with left ventricular structure and function in rheumatoid arthritis. Geraldino-Pardilla L, Russo C, Sokolove J, Robinson WH, Zartoshti A, Van Eyk J, Fert-Bober J, Lima J, Giles JT, Bathon JM. Rheumatology. 2017 Apr 1; 56(4):534-540. Citrullination of myofilament proteins in heart failure. Fert-Bober J, Giles JT, Holewinski RJ, Kirk JA, Uhrigshardt H, Crowgey EL, Andrade F, Bingham III CO, Park JK, Halushka MK, et al. Cardiovasc Res. 2015 Nov 1; 108(2):232-242. Contact the Fert-Bober Lab Advanced Health Sciences Pavilion, Suite 3100 8700 Beverly Blvd. Los Angeles, CA 90048 424-315-2383 Fax: 310-423-3522 Send a Message Please ensure Javascript is enabled for purposes of website accessibility