Cui Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Cui Lab The Cui Laboratory conducts translational cancer research to decipher biochemical and signaling mechanisms of cancer development, metastasis and therapeutic resistance. The Cui Lab aims to use these mechanisms to identify potential targets for therapeutic interventions of the signaling pathways. The ultimate goal is to develop effective anticancer therapies based on these targets. The Cui Laboratory is affiliated with the Samuel Oschin Comprehensive Cancer Institute and Surgery Department. Personal Statement Xiaojiang Cui, PhD, obtained his doctorate in molecular biology from the University of Texas at Austin. He received his postdoctoral training at the renowned Baylor College of Medicine Lester and Sue Smith Breast Center in Houston where he later became an instructor. Cui studied growth factor signaling in the development of the mammary gland and breast cancer. His findings have important implications for understanding hormonal therapy response and the increased breast cancer risk after hormone replacement therapy. Xiaojiang Cui, PhD Breakthrough Research Areas The Cui Laboratory has found that the FOXC1 transcription factor, which is involved in embryonic development, is a critical biomarker for BLBC. FOXC1 overexpression induces breast cancer cell growth, migration, invasion and chemo resistance. The Cui Lab is now using cell models to identify the signaling pathways mediating the effect of FOXC1 on BLBC cell functions. We also exploit mammary-specific overexpression and knockout mouse models to determine whether FOXC1 regulates BLBC development in vivo and predisposes breast cancer to brain and lung metastasis. Internal Collaborations Board of Governors Regenerative Medicine Institute Department of Biomedical Sciences Department of Surgery Armando Giuliano, MD Knott Laboratory Medina-Kauwe Laboratory Murali Laboratory Sareen Laboratory Tanaka Laboratory Women's Health Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Cui Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Breast cancer lung metastasis: molecular biology and therapeutic implications. Jin L, Han B, Siegel E, Cui Y, Giuliano A, Cui X. Cancer Biol Ther. 2018;19(10):858-868. Resistance to receptor-blocking therapies primes tumors as targets for HER3-homing nanobiologics. Sims JD, Taguiam JM, Alonso-Valenteen F, Markman J, Agadjanian H, Chu D, Lubow J, Abrol R, Srinivas D, Jain A, Han B, Qu Y, Mirzadehgan P, Hwang JY, Rentsendorj A, Chung A, Lester J, Karlan BY, Gray HB, Gross Z, Giuliano A, Cui X, Medina-Kauwe LK. J Control Release. 2018 Feb 10;271:127-138. FOXC1-induced non-canonical WNT5A-MMP7 signaling regulates invasiveness in triple-negative breast cancer. Han B, Zhou B, Qu Y, Gao B, Xu Y, Chung S, Tanaka H, Yang W, Giuliano AE, Cui X. Oncogene. 2018 Mar;37(10):1399-1408. Contact the Cui Lab 8700 Beverly Blvd. Davis Building, Rooms 2055 and 2056 Los Angeles, CA 90048 310-423-7437 Fax:310-423-9537 Send a Message Please ensure Javascript is enabled for purposes of website accessibility