Crother Laboratory at Cedars-Sinai Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Crother Lab Areas of research in the Crother Laboratory include acute lung infections and host-pathogen interactions, in addition to allergic asthma models. The Crother Lab also investigates the mechanisms by which RIP2 in T cells controls the induction of pathogenic Th17 skewing and its implication in inflammatory bowel disease mouse models. Finally, we are studying how C. pneumoniae infections can modulate Alzheimer’s disease progression. The Crother Laboratory is affiliated with the Infectious and Immunologic Diseases Research Center, Department of Biomedical Sciences and the Pediatrics Department. Personal Statement As a researcher, one of my key interests has centered on host-pathogen interactions. This has led me to investigate how Borrelia burgdorferi, the causative agent of Lyme Disease, remakes itself when it infects a mammalian host, and how Chlamydia pneumoniae infections can drive asthmatic responses, and also exacerbate atherosclerotic plaque development. More recently, I have become interested in the possibility that infectious agents may play a role in the development and progression of Alzheimer’s Disease. While there is evidence that infections may play a role in AD, few direct studies have been attempted, highlighting the need for new investigations. Timothy R. Crother, PhD Breakthrough Research Areas The Role of Infectious Diseases in the Etiology of Alzheimer’s Disease T-cell RIP2 and Inflammatory Bowel Disease Pulmonary Infections Innate Immunity and Asthma Collaborations Arditi Laboratory Chen Laboratory Koronyo-Hamaoui Laboratory Noval Rivas Laboratory Shimada Laboratory Meet Our Team Learn more about the researchers of the Crother Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Recruitment of pro-IL-1α to mitochondrial cardiolipin, via shared LC3 binding domain, inhibits mitophagy and drives maximal NLRP3 activation. Dagvadorj J, Mikulska-Ruminska K, Tumurkhuu G, Ratsimandresy RA, Carriere J, Andres AM, Marek-Iannucci S, Song Y, Chen S, Lane M, Dorfleutner A, Gottlieb RA, Stehlik C, Cassel S, Sutterwala FS, Bahar I, Crother TR, Arditi M. Proc Natl Acad Sci U S A. 2021 Jan 5;118(1):e2015632118. T-cell-intrinsic receptor interacting protein 2 regulates pathogenic T helper 17 cell differentiation. Shimada K, Porritt RA, Markman JL, O’Rourke JG, Wakita D, Rivas MN, Ogawa C, Kozhaya L, Martins GA, Unutmaz D, Baloh RH, Crother TR, Chen S, Arditi M. Immunity. 2018 Nov 20;49(5):873-885.e7. Autophagy limits inflammasome during chlamydia pneumoniae infection. Crother TR, Porritt RA, Dagvadorj J, Tumurkhuu G, Slepenkin AV, Peterson EM, Chen S, Shimada K, Arditi M. Front Immunol. 2019 Apr 12;10:75. Mast cells play an important role in Chlamydia pneumoniae lung infection by facilitating immune cell recruitment into the airway. Chiba N, Shimada K, Chen S, Jones HD, Alsabeh R, Slepenkin AV, Peterson E, Crother TR, Arditi M. J Immunol. 2015 Apr 15;194(8):3840-3851. Contact the Crother Lab 8700 Beverly Blvd. Davis Building, Room 4025 Los Angeles, CA 90048 Lab 310-423-7970 Office 310-423-1423 Send a Message Please ensure Javascript is enabled for purposes of website accessibility