Chen Research Lab Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Chen Lab The Chen Laboratory is unraveling basic mechanisms of lung injury and repair. Our focus is on how lung epithelial cells interact with other cellular compartments and with the extracellular matrix to regulate inflammatory cell recruitment and lung fibrosis in various cell-based and animal models. The Chen Laboratory is affiliated with the Department of Medicine and Women's Guild Lung Institute. Personal Statement I have had a long-standing interest in the lung epithelial response to injury and how aberrant responses acutely lead to lung injury and chronically promote pathological outcomes such as lung fibrosis. The initial work from my laboratory focused on epithelial interactions with the matrix identifying specific mechanisms regulating re-epithelialization. More recently, my research group has investigated mechanisms by which the lung mucosal immunity regulates acute lung injury after infectious insults." Peter Chen, MD Breakthrough Research Areas COVID-19 mechanisms and therapeutics Dysbiosis and post-influenza MRSA infection Syndecan-1 and influenza infection Syndecan-1 and lung fibrosis Dynactin-4 polymorphisms and pseudomonas colonization in cystic fibrosis Collaborations Goodridge Laboratory Underhill Laboratory Devkota Laboratory Medina-Kauwe Laboratory Stripp Laboratory Sutterwala & Cassel Laboratory Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Chen Laboratory, whose dedicated efforts lead to groundbreaking discoveries. View Our Team Publications Syndecan-1 promotes lung fibrosis by regulating epithelial reprogramming through extracellular vesicles. Parimon T, Yao C, Habiel DM, Ge L, Bora SA, Brauer R, Evans CM, Xie T, Alonso-Valenteen F, Medina-Kauwe LK, Jiang D, Noble PW, Hogaboam CM, Deng N, Burgy O, Antes TJ, Königshoff M, Stripp BR, Gharib SA, Chen P. JCI Insight. 2019 Aug 8;5(17):e129359. Cell-Type-Specific Immune Dysregulation in Severely Ill COVID-19 Patients. Yao C, Bora SA, Parimon T, Zaman T, Friedman OA, Palatinus JA, Surapaneni NS, Matusov YP, Cerro Chiang G, Kassar AG, Patel N, Green CER, Aziz AW, Suri H, Suda J, Lopez AA, Martins GA, Stripp BR, Gharib SA, Goodridge HS, Chen P. Cell Rep. 2021 Jan 5;34(1):108590. SARS-CoV-2 Neutralizing Antibody LY-CoV555 in Outpatients with Covid-19. Chen P, Nirula A, Heller B, Gottlieb RL, Boscia J, Morris J, Huhn G, Cardona J, Mocherla B, Stosor V, Shawa I, Adams AC, Van Naarden J, Custer KL, Shen L, Durante M, Oakley G, Schade AE, Sabo J, Patel DR, Klekotka P, Skovronsky DM; BLAZE-1 Investigators. N Engl J Med. 2021 Jan 21;384(3):229-237. Contact the Chen Lab 127 S. San Vicente Blvd. Pavilion, A-9404 Los Angeles, CA 90048 424-315-2864 Send a Message Please ensure Javascript is enabled for purposes of website accessibility