Silm Laboratory Cedars-Sinai Skip to content Close Select your preferred language English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog English English عربى 简体中文 繁體中文 فارسي עִברִית 日本語 한국어 Русский Español Tagalog Translation is unavailable for Internet Explorer Cedars-Sinai Home 1-800-CEDARS-1 1-800-CEDARS-1 Close Find a Doctor Locations Programs & Services Health Library Patient & Visitors Community My CS-Link RESEARCH clear Go Close Navigation Links Academics Faculty Development Community Engagement Calendar Research Research Areas Research Labs Departments & Institutes Find Clinical Trials Research Cores Research Administration Basic Science Research Clinical & Translational Research Center (CTRC) Technology & Innovations News & Breakthroughs Education Graduate Medical Education Continuing Medical Education Graduate School of Biomedical Sciences Professional Training Programs Medical Students Campus Life Office of the Dean Simulation Center Medical Library Program in the History of Medicine About Us All Education Programs Departments & Institutes Faculty Directory Silm Lab The Silm Lab is focused on understanding how the regulation of neurotransmitter release affects the properties of information processing. We are specifically focused on neuromodulators like dopamine, serotonin and norepinephrine, as well as neurons that use multiple neurotransmitters for conveying information about neural activity along brain circuits. Personal Statement Problems with neuromodulatory signaling are central to many human diseases, from addiction to movement disorders. Over the past decades, the scientific community has gained significant understanding of the general principles of neurotransmission, including the regulatory mechanisms of neurotransmitter release. However, very little of this research has been conducted in neurons that release neuromodulators, and recent evidence suggests that neuromodulator release differs from the release of fast synaptic transmitters like glutamate. Uncovering the mechanisms behind neuromodulatory signaling is crucial for understanding how these molecules work to assure normal brain function, and what goes wrong in disease states. Katlin Silm, PhD Breakthrough Research Areas Molecular mechanism of neuromodulator release Presynaptic regulation in information processing and brain function Role of neurotransmitter co-release in reward processing and movement disorders Collaborations Center for Neural Science and Medicine Department of Biomedical Sciences Neurology Department Meet Our Team Learn more about the scientists, faculty members, investigators and other healthcare professionals of the Silm Laboratory, whose dedicated efforts lead to groundbreaking discoveries. VIEW OUR TEAM Publications Synaptic Vesicle Recycling Pathway Determines Neurotransmitter Content and Release Properties Silm K, Yang J, Marcott PF, Asensio CS, Eriksen J, Guthrie DA, Newman AH, Ford CP, Edwards RH. Neuron. 2019 May 22;102(4):786-800.e5. A proline-rich motif on VGLUT1 reduces synaptic vesicle super-pool and spontaneous release frequency Zhang XM, François U, Silm K, Angelo MF, Fernandez-Busch MV, Maged M, Martin C, Bernard V, Cordelières FP, Deshors M, Pons S, Maskos U, Bemelmans AP, Wojcik SM, El Mestikawy S, Humeau Y, Herzog E. Elife. 2019 Oct 30;8:e50401. In vivo imaging of intersynaptic vesicle exchange using VGLUT1 Venus knock-in mice Herzog E, Nadrigny F, Silm K, Biesemann C, Helling I, Bersot T, Steffens H, Schwartzmann R, Nägerl UV, El Mestikawy S, Rhee J, Kirchhoff F, Brose N. J Neurosci. 2011 Oct 26;31(43):15544-59. Contact the Silm Lab Cedars-Sinai 127 S. San Vicente Blvd. Pavilion, 8th Floor Los Angeles, CA 90048 Send a Message Please ensure Javascript is enabled for purposes of website accessibility