11 of the best CBD oils for anxiety Products choosing and more
11 of the best CBD oils for anxiety: Products, choosing, and more Health ConditionsHealth ConditionsAlzheimer's & DementiaAnxietyArthritisAsthma & AllergiesBreast CancerCancerCardiovascular HealthCOVID-19Dermatology & SkincareDiabetesEnvironment & SustainabilityExercise & FitnessEye HealthHeadache & MigraineHealth EquityHIV & AIDSHuman BiologyInflammatory Bowel DiseaseLeukemiaLGBTQIA+Men's HealthMental HealthMultiple Sclerosis (MS)NutritionParkinson's DiseasePsoriasisSexual HealthWomen's HealthDiscoverNewsLatest NewsOriginal SeriesMedical MythsHonest NutritionThrough My EyesNew Normal HealthPodcastsHow to understand chronic painWhat is behind vaccine hesitancy?The amazing story of hepatitis C, from discovery to cureNew directions in dementia researchCan psychedelics rewire a depressed, anxious brain?Why climate change matters for human healthToolsGeneral HealthDrugs A-ZHealth HubsHealth ToolsBMI Calculators and ChartsBlood Pressure Chart: Ranges and GuideBreast Cancer: Self-Examination GuideSleep CalculatorHealth ProductsAffordable Therapy OptionsBlood Pressure MonitorsDiabetic SuppliesFitness TrackersHome GymsGreen Cleaning ProductsHow to Shop for CBDQuizzesRA Myths vs FactsType 2 Diabetes: Managing Blood SugarAnkylosing Spondylitis Pain: Fact or FictionConnectAbout Medical News TodayWho We AreOur Editorial ProcessContent IntegrityConscious LanguageNewslettersSign UpFollow UsMedical News TodayHealth ConditionsDiscoverToolsConnectSubscribe 11 of the best CBD oils for anxietyMedically reviewed by Eloise Theisen, RN, MSN, AGPCNP-BC — By Kristina Iavarone and Anne deLeeuw — Updated on June 23, 2022We include products we think are useful for our readers. If you buy through links on this page, we may earn a small commission. Here’s our process. Is CBD legal Hemp-derived CBD products with less than 0.3% THC are legal federally but still illegal under some state laws. Cannabis-derived CBD products, on the other hand, are illegal federally but legal under some state laws. Check local legislation, especially when traveling. Also, keep in mind that the Food and Drug Administration (FDA) has not approved nonprescription CBD products, which may be inaccurately labeled. Cannabidiol (CBD) is a natural compound present in the Cannabis sativa plant. Research suggests that it may help treat anxiety disorders and other conditions. Share on Pinterest A quick look at 11 of the best CBD oils for anxietyBest CBD isolate: Kanibi CBD Pure Isolate (Skittle flavor)Best full-spectrum Lazarus Naturals High Potency TinctureBest for a non-GMO tincture Papa & Barkley Hemp Releaf DropsBest for CBD with terpenes LiftMode Hemp Simply Distilled CBD Distillate OilBest for faster absorption Green Roads Full Spectrum CBD OilBest for a broad spectrum oil Green Gorilla Broad Spectrum CBD OilBest for a water-soluble CBD oil Ojai Energetics Full Spectrum Hemp ElixirBest for a 30-day trial: Holmes Organic CBD Oil TincturesBest for multiple flavors FOCL Premium CBD DropsBest for a neutral taste Lord Jones Royal OilBest for a larger bottle Charlotte s Web CBD OilThis article explores whether CBD can help with anxiety. It also discusses some products to consider and outlines regulations and health considerations. About CBD The plant Cannabis sativa contains two active ingredients: CBD and delta-9-tetrahydrocannabinol (THC). THC has psychoactive properties that are responsible for the high feeling that some people experience with cannabis use. However, most CBD in CBD oil comes from the hemp plant, which is a variety of C. sativa. This type of CBD is nonpsychoactive, so a person should not experience the high feeling that cannabis delivers. However, some CBD products may contain traces of THC. Still, other CBD oils are derived solely from marijuana cannabis. This marijuana-derived CBD oil has the same chemical structure as and similar properties to hemp-derived CBD oil, but it is not legal according to federal law or the laws in most states. Learn more about the differences between CBD and THC here. CBD terminology The following table defines common CBD terms.TermMeaningCBDA compound within the C. sativa plant that does not create the high sensation individuals commonly associate with cannabis use.THCA compound in the C. sativa plant. It is the psychoactive compound that creates the high sensation from cannabis use.Full-spectrumA full-spectrum product will contain all of the natural compounds in the cannabis plant, including THC. However, THC levels must be no more than 0.3% to comply with Food and Drug Administration (FDA) regulation on full-spectrum CBD products.Broad-spectrumBroad-spectrum products contain natural compounds of the cannabis plant. However, while manufacturers remove all or most of the THC in broad-spectrum CBD, it may still be present in trace amounts.CBD isolateThis is the purest form of CBD and should contain 0% THC.CannabinoidsThe compounds within the cannabis plant, of which there are over 120. CBD is the second richest compound in the plant after THC. TerpenesAnother compound of the C. sativa plant, terpenes typically give plants their specific aromas. Some terpenes, such as limonene, may have specific health benefits.Certificate of analysis (COA)Reputable manufacturers of CBD products should ensure a COA is available for inspection. A COA provides information on the third-party testing that independent labs conduct on a particular product. Sometimes, products will have a scannable smartphone code that directs people to the COA online. Read more about terminology and other important CBD information here. How we chose Medical News Today chooses products that meet the following criteria:Ingredients: Products contain safe and high-quality ingredients and list all ingredients clearly. They should also confirm they are free from pesticides, heavy metals, and mold.Dosage: Products contain or recommend a serving size of a safe CBD dosage. The product clearly states the dosage.Third-party labs: Products undergo third-party testing for contaminants by an ISO 17025-compliant laboratory.Available certificate of analysis: The company demonstrates transparency and shares its product’s certificate of analysis (COA) following lab results. Top CBD products for anxiety Please note that the writer of this article has not tried these products. All information presented is purely research-based and correct at the time of publication. Medical News Today follows a strict product selection and vetting process. Learn more here. Best for CBD isolate Kanibi CBD Pure Isolate Skittles flavor CBD type: CBD isolateStrength: 25 – 50 mg of CBD per mlSize: 30 mlPrice: $109 This CBD isolate contains pure CBD from organic hemp and no THC. It has no artificial colors, flavors, or preservatives. A 1-milliliter (ml) dropper of a 750-milligram (mg) tincture contains 25 mg of CBD, while a 1 ml dropper of a 1,500-mg tincture contains 50 mg of CBD. Kanibi recommends that a person begins with 10 mg per day if they have never tried CBD before. If it is not effective, they may wish to increase the dose by 5 or 10 mg every 5 days. The company states that the extract in its pure isolate goes through an extra purification step to remove additional ingredients, such as THC, terpenes, and plant compounds. This process creates a crystalline powder of pure CBD, and the company infuses it into MCT oil. Pros and cons The company states that this product is organic and does not have any artificial colors, flavors, or preservatives. Additionally, Kanibi offers free shipping, and all of its products are double lab-tested for safety and potency. However, this oil is one of the more expensive products available. It may also not be suitable for people who wish to purchase a product that contains THC.SHOP NOW Best full-spectrum Lazarus Naturals High Potency TinctureCBD type: full-spectrumStrength: 50 mg of CBD per mlSize: 120-ml bottlesPrice: $120 The Lazarus Naturals high potency tincture is a full-spectrum CBD oil that contains 50 mg of CBD per ml. The product comes in a 120 ml bottle. The company suggests that a person starts with 50 mg to find the right amount. They may increase the dosage as needed after 2 hours. However, people who have never used CBD before might prefer to start with a much lower dosage of about 5-10 mg and increase the amount as they become more accustomed to it. Lazarus Naturals claims its products do not cure or treat health conditions, so if individuals have any health concerns, they should contact a qualified healthcare professional for advice. Pros and cons The company uses hemp grown on its farm, and it extracts CBD using ethanol-based processes. It then dilutes the extract with coconut oil to ensure that the product contains the right CBD concentration. The company states that all its tinctures have undergone third-party testing for potency, pesticides, and heavy metals. However, this product contains coconut oil. People who have an allergy to coconut should avoid this product. Additionally, this product is more expensive than some other CBD oils. Learn more about Lazarus Naturals here.SHOP NOW Best for a non-GMO tincture Papa & Barkley Hemp Releaf DropsCBD type: full-spectrumStrength: 450-900 mg of CBD per bottleSize: 15-60 mlPrice: from $34.99 These drops contain full-spectrum hemp and medium-chain triglycerides (MCT) oil. It is available in two flavors: lemongrass ginger and natural. A person can purchase 15-ml drops containing 450 mg of CBD or 30-ml drops containing 900 mg of CBD. Individuals with anxiety may consider this product to help them:manage stress betterfocus and concentratefall and stay asleep The company states that people who are pregnant, breastfeeding, or taking prescription-based medications should seek medical advice before using these drops. Pros and cons The drops are chemical-free, as they do not contain isolates, distillates, or solvents. This is because the company uses a whole plant infusion process to extract CBD, which avoids harsh chemicals. Additionally, the company collaborates with Nutrasource, ensuring that Papa & Barkley products do not contain genetically modified organisms (GMO). However, some customers state that the bottle leaks if a person shakes the product. Learn more about Papa & Barkley here.SHOP NOW Best for CBD with terpenes LiftMode Hemp Simply Distilled CBD Distillate OilCBD type: full-spectrumStrength: 1500 mg of CBD per bottleSize: 30 mlPrice: $36.68 LiftMode Hemp extract oil is a full-spectrum product containing terpenes, organic coconut oil, and oleic acid. It contains less than 0.3% THC. LiftMode Hemp recommends using half a dropper, or 0.5 ml, up to twice per day. The product may cause drowsiness, so individuals should avoid driving after use. People taking prescription-based medications should seek medical advice before purchasing this CBD oil. However, it may not be safe for pregnant people or those that are breastfeeding, or chestfeeding, to use. The product is free from gluten, lactose, GMOs, and excipients, including preservatives and coloring agents. Pros and cons The company states that this product contains naturally occurring terpenes and cannabinoids, which may lead to an entourage effect, increasing the effectiveness of this product. However, this product contains coconut oil and is not suitable for those with a coconut allergy. Learn about the difference between hemp CBD and cannabis CBD here.SHOP NOW Best for faster absorption Green Roads Full Spectrum CBD OilCBD type: full-spectrumStrength: 50 mg of CBD per mlSize: 30 mlPrice: $109.99 Green Roads states that this oil is pharmacist-formulated. It is a full-spectrum, hemp-derived CBD oil with a sweet flavor and subtle hints of caramel. This oil contains 50 mg of CBD per ml, or 1,500 mg per 30 ml bottle. The company states that it is vegan and free from gluten and artificial colors and flavors. The company also states that the extra ingredients in this product, such as MCT, sunflower, and hemp seed oil, may lead to faster absorption. Green Roads recommends people place their desired amount underneath their tongue for 30 seconds before swallowing. Pros and cons An independent lab tests each batch and people can view all certificates of analysis on the company’s website. However, this product is more expensive than some of the other options available. Additionally, people may find that this product is too strong, especially for those who are new to using CBD. Use code MNT20 for 20% off your orderSHOP NOW Best for a broad spectrum oil Green Gorilla Broad Spectrum CBD OilCBD type: broad-spectrumStrength: 20 mg of CBD in every 2 ml servingSize: 60 mlPrice: $79.99 This broad-spectrum, certified organic oil contains 600 mg of CBD per 60 ml bottle. It includes phytocannabinoids, terpenes, and flavonoids in every serving. Some customers state that this product may help promote calm and recovery. The company recommends using five pumps of this oil per day, holding the oil underneath the tongue for at least 30 seconds. Pros and cons All of Green Gorilla’s products have third-party lab testing, and people can access the QR codes for each product on the website. However, this product may not be suitable for those who want to use a product with THC.SHOP NOW Best for a water-soluble CBD oil Ojai Energetics Full Spectrum Hemp ElixirCBD type: full-spectrumStrength: 250 mg of CBD per bottleSize: 30 mlPrice: from $74.95 Ojai states that this full-spectrum oil is organic, water-soluble, and synthetic-free. The company claims that the synthetic-free water-soluble CBD absorbs faster than other options. This oil also includes hemp seed oil, moringa, and acerola cherry, which are all rich in nutrients such as omega-3, vitamin A and C, and calcium. The company recommends taking 1 ml of oil per serving. Pros and cons People can choose to purchase multipacks of this oil, which may be less expensive. However, people who are looking for a stronger CBD oil may prefer to choose a different product.SHOP NOW Best for a 30-day trial Holmes Organics CBD Oil TincturesCBD type: broad-spectrumStrength: 450 and 900 mg of CBD per bottleSize: 30 mlPrice: from $49.95 Holmes Organic states that this broad-spectrum, organic, tincture contains high quality and fast acting hemp extracts without any THC. The hemp in this product is US-grown, and the company used CO2 extraction to create the CBD oil. Holmes Organic states that using CO2 to extract the CBD leads to a purer product than other methods. Holmes Organic recommend placing the oil in the mouth and swallowing. Pros and cons People can search for all of the company’s third-party lab results on the website. In addition, Holmes Organics offers a 30-day risk-free trial and free shipping. However, this product is unflavored. Those who do not like the flavor of CBD oil may prefer to purchase a different product.SHOP NOW Best for multiple flavors FOCL Premium CBD DropsCBD type: broad-spectrumStrength: 1,000–3,000 mg of CBD per bottleSize: 30 mlPrice: from $59 This broad-spectrum and organic CBD oil contains 1,000–3,000 mg of CBD per bottle. It also contains MCT oil. The company states that this product has third-party testing and that it manufacturers all of its products in a GMP-certified food-grade facility. FOCL recommends taking a 10-20 mg dose twice a day, gradually increasing by 5–10 mg until a person attains their desired effects. Pros and cons People can choose from several flavors, such as mint, orange cream, and strawberry lemonade. In addition, people can view the test results of this product on the company’s website. However, this product may not be suitable for people who are not used to taking CBD, or those who prefer a lesser strength. Use code MNT20 for 20% off your first orderSHOP NOW Best for a neutral taste Lord Jones Royal OilCBD type: broad-spectrumStrength: 20 mg of CBD per 0.6 mlSize: 15 mlPrice: $50 This is broad-spectrum CBD oil contains 500 mg of CBD per bottle. The company states that its second ingredient, grapeseed oil, gives the product a neutral taste. Lord Jones recommends using this oil as a supplement or applying it directly to the skin. The company warns people not to exceed 60 mg, or 3 droppers, a day. Pros and cons This CBD oil may have a more neutral taste than other unflavored products due to the grapeseed oil. However, some people may prefer to purchase a product with more CBD per serving, or a product that contains more oil.SHOP NOW Best for a larger bottle Charlotte s Web CBD OilCBD type: full-spectrumStrength: 60 mg of CBD per mlSize: 30–100 mlPrice: from $119.99 This organic full-spectrum CBD oil contains 60 mg of CBD per ml, which is one of the highest concentrations available. The company states that this product contains phytocannabinoids, terpenes, flavonoids, and essential fatty acids. This product is available in multiple flavors, such as mint chocolate and lemon twist. Pros and cons People can choose to purchase a 30 or 100 ml bottle, which is one of the largest bottles of CBD available to purchase. In addition, people can choose to subscribe and receive the CBD oil regularly for a discount. However, this product contains a high amount of CBD per ml. People who are not used to taking CBD may prefer to purchase a product with less CBD. Use code “HEALTH20” for 20% off.SHOP NOW Comparison chart The following tables compares the CBD oils in this article.Type of CBDCBD strengthBottle sizePriceKanibiCBD isolatefrom 25 mg per ml30 ml$109Lazarus Naturalsfull-spectrum50 mg per ml120 ml$120Papa & Barkleyfull-spectrumfrom 450 mg per bottlefrom 15 mlfrom $34.99Liftmodefull-spectrum1500 mg per bottle30 ml$36.68Green Roadsfull-spectrum50 mg per ml30 ml$109.99Green Gorillabroad-spectrum20 mg per serving60 ml$79.99Ojai Energeticsfull-spectrum250 mg per bottle30 ml$74.95Holmes Organicbroad-spectrumfrom 450 mg per bottle30 ml$49.95FOCLbroad-spectrumfrom 1,000 mg per bottle30 mlfrom $59Lord Jonesbroad-spectrum20 mg per serving15 ml$50Charlotte’s Webfull-spectrum60 mg per mlfrom 30 mlfrom $119.99 How to shop for CBD products There are several things a person should consider when selecting a CBD product for themselves. Look for products that a third-party lab has tested. Third-party testing means a CBD company has sent their product to an accredited lab to test for quality. The manufacturer then makes the testing results publicly available through certificates of analysis (COAs). Compare the COA to the product label to ensure the product contains the listed amount of THC, CBD, or both and that it does not contain contaminants, such as heavy metals or pesticides. Besides quality and safety, the main criteria that guide a person’s choice of CBD products will be their personal preferences and requirements. Someone whose anxiety primarily affects them during the day when they are busy may want to look for a low-potency CBD product that they can consume while they are out and about. Depending on the effects they want from a CBD product, a person should check labels for the terms full-spectrum, broad-spectrum, and CBD isolate. Full-spectrum means a product contains THC and will produce an entourage effect when all the phytocannabinoids and terpenes work together. Broad-spectrum means the product contains other cannabis plant compounds but is generally THC-free.CBD isolateonly contains pure CBD and no other compounds from the cannabis plant. If a person has concerns about the potential psychoactive effects of full-spectrum or broad-spectrum CBD products, they may opt for a CBD isolate.Learn more about buying CBD here. Types of CBD There are three types of CBD products:Full-spectrum CBD: These products contain naturally occurring extracts from the cannabis plant. They also contain up to 0.3% THC.Broad-spectrum CBD: These products contain naturally occurring compounds that come from the cannabis plant. However, they are free of THC.CBD isolate: This is a pure form of CBD that does not contain THC, other cannabinoids, or plant compounds. It has no odor or taste. Additionally, two main types of products fall into the CBD oil category: CBD oils and CBD tinctures. The difference lies in the manufacturing process. For CBD oil, manufacturers infuse carrier oil with CBD to create the product. For a CBD tincture, manufacturers soak cannabis in alcohol and glycerin to produce the product. Learn about the different types of CBD here. What is anxiety Anxiety is a feeling of unease and the body’s natural reaction to stress. People may develop anxiety when they experience a stressful event or have a chronic condition or other disorders, such as alcohol use disorder. There are different types of anxiety disorders, including panic disorder, phobia-related disorders, and generalized anxiety disorder (GAD), which affect 6.8 million adults in the United States. People with anxiety disorders may experience:dizzinessheart palpitationsrestlessness difficulty concentratingshortness of breath Anxiety can cause depression, heart disease, stroke, and sometimes premature death if left untreated. Learn how to recognize an anxiety attack here. Can CBD treat anxiety A 2019 case study notes that CBD products may benefit people with anxiety disorders. The researchers studied the effects of CBD in 72 individuals with anxiety and poor sleep patterns. After treatment with CBD, 79% of the participants experienced decreased anxiety levels, and 66.7% saw improved sleep scores. However, these scores fluctuated over time. Authors of another study claim that there is insufficient research to determine the appropriate dosage of CBD for anxiety-related disorders. However, they examined the role of CBD in individuals with GAD, social anxiety disorder, and anxiety associated with post-traumatic stress disorder (PTSD). They found that the participants tolerated CBD well and reported minimal adverse effects, such as fatigue and sedation. Learn more about CBD and anxiety here. What the research says Research is ongoing into CBD’s potential to treat anxiety and depression, along with a host of other conditions. To confirm the effective dosages for specific conditions, scientists still need to conduct large-scale clinical trials. Currently, a 2015 review of existing studies demonstrates that CBD has the potential to treat anxiety disorders, such as:social anxiety disorderobsessive-compulsive disorder (OCD)GADPTSDpanic disorder Learn more about research into CBD dosages here. Pros and cons of using CBD There are pros and cons of using CBD oil, depending on a person’s preferences and health requirements. These include: ProsCBD may reduce some symptoms of depression and anxiety.Most CBD products are easily portable, and people can use them on the go.CBD products are available in a range of pleasing flavors.CBD products are easy to self-administer and suitable for people who may not like swallowing pills. Safety and side effects Generally, experts consider CBD oil to be safe. However, CBD products may still cause side effects, including:fatiguediarrheachanges in appetiteundesired weight loss or weight gain A person should always talk with a doctor before taking any new supplement, including CBD. This is especially true if somebody is taking medication, as CBD products may interact with some medications. Individuals taking CDB may wish to avoid taking CBD along with high-fat meals. According to a 2020 study, fats can increase the risk of side effects by increasing the concentration of CBD in the blood. Some 2019 research suggests that CBD can cause liver toxicity. However, this study took place on mice, and researchers concluded that a person would have to take an extremely high dose to incur this risk.Learn whether CBD is addictive here. How to use CBD products A person should ingest CBD oils and tinctures by: using the dropper to measure the desired amount squeezing the drops under the tongue holding them there for 20 seconds before swallowing Anyone new to CBD should start with a low dose and gradually build up the amount they take should they want to. Learn the difference between CBD oils and tinctures here. CBD regulations The Food and Drug Administration (FDA) does not currently guarantee the safety, effectiveness, or quality of CBD products that a person can purchase over the counter or without a prescription. According to the FDA, many companies market unapproved products containing CBD. The FDA can take action against CBD companies that make baseless health claims to protect public health. The FDA has approved one product called Epidiolex to treat three rare and severe forms of epilepsy. This product is only available with a prescription. All 50 U.S. states have different restrictions and laws regarding CBD use. A person can check this information with their state Health and Human Services department.Learn more about using CBD for seizures here. Health considerations CBD may be safe if a person takes it by mouth or sprays it under the tongue. However, some people may experience:nausea and vomitingfatiguediarrheadrowsinessmood changes Individuals should seek medical advice before using CBD products. According to the FDA, people may experience sedation and drowsiness if they take CBD while receiving treatment for anxiety, stress, panic, or sleep disorders. Learn more about CBD and sleep here. When to contact a doctor A person should always contact a healthcare professional before using CBD products, as CBD may interact with other medications, causing serious side effects. A doctor can advise a person on whether any medications they are currently taking may have adverse interactions with CBD. People should also contact a doctor if they are experiencing any symptoms of anxiety that are interfering with their quality of life. People should not use CBD as a substitute for medication or therapy for anxiety. Frequently Asked Questions Below are some answers to common questions people may ask about CBD: Do CBD products do what their manufacturers claim Some research supports CBD’s ability to treat various conditions, such as sleep difficulties, anxiety, and pain. However, the FDA state that there is little evidence to support most of these claims. Although some manufacturers claim their products can treat conditions such as diabetes, it is illegal for companies to claim that the CBD products they manufacture can treat or cure any serious diseases.Learn what the research says about CBD and diabetes here. Is CBD legal CBD products are legal to a certain extent, with some caveats. CBD products made from hemp are legal under federal law if they contain less than 0.3% THC. State laws vary considerably; therefore, individuals should check with the relevant regulations in their home state before purchasing any CBD products Does CBD produce a high CBD does not produce a euphoric or high feeling. THC is the psychoactive compound found in cannabis plants and their derivatives that cause a high feeling. CBD products must contain less than 0.3% THC under federal law, and some do not contain any THC at all.Learn whether CBD causes a high here. Summary Researchers are still studying the effectiveness of CBD on anxiety and other health conditions. The FDA does not regulate CBD, and rules differ in all 50 U.S. states. Some CBD products may help people manage stressful situations, sleep better, and reduce their anxiety levels, but researchers need to carry out more studies to confirm this. CBD products may not suit everyone. People taking supplements or prescription medications should seek guidance from a doctor before using any product containing CBD. Last medically reviewed on May 8, 2022Uncategorized 16 sourcescollapsedMedical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Alsherbiny, M. A., et al. (2018). Medicinal cannabis - potential drug interactions.https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC6473892/Anxiety disorders. (2018).https://www.nimh.nih.gov/health/topics/anxiety-disorders/index.shtml#part_145338Blessing, E. M., et al. (2015). Cannabidiol as a potential treatment for anxiety disorders.https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC4604171/Cannabidiol (CBD). (2020).https://medlineplus.gov/druginfo/natural/1439.htmlCrockett, J., et al. (2020). A phase 1, randomized, pharmacokinetic trial of the effect of different meal compositions, whole milk, and alcohol on cannabidiol exposure and safety in healthy subjects.https://pubmed.ncbi.nlm.nih.gov/32012251/Ewing, L. E., et al. (2019). Hepatotoxicity of a cannabidiol-rich cannabis extract in the mouse model.https://pubmed.ncbi.nlm.nih.gov/31052254/FDA regulation of cannabis and cannabis-derived products, including cannabidiol (CBD). (2021).https://www.fda.gov/news-events/public-health-focus/fda-regulation-cannabis-and-cannabis-derived-products-including-cannabidiol-cbdFood and Drug Administration (2020). FDA approves first drug comprised of an active ingredient derived from marijuana to treat rare, severe forms of epilepsy [Press release].https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-comprised-active-ingredient-derived-marijuana-treat-rare-severe-formsGeneralized anxiety disorder (GAD). (n.d.).https://adaa.org/understanding-anxiety/generalized-anxiety-disorder-gadGMP: Food safety management. (n.d.).https://www.nqa.com/en-bd/certification/standards/gmp?gclid=CjwKCAjwtIaVBhBkEiwAsr7-cz2jQ59YtafkROPpo8zz1Z3o6B3c7KwBlR5wWN3Xjq2dUJcSnHIAHxoCdsYQAvD_BwEIffland, K., et al. (2017). An update on safety and side effects of cannabidiol: A review of clinical data and relevant animal studies.https://www.liebertpub.com/doi/10.1089/can.2016.0034Shannon, S., et al. (2019). Cannabidiol in anxiety and sleep: A large case series.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/Skelley, J. W., et al. (2020). Use of cannabidiol in anxiety and anxiety-related disorders [Abstract].https://www.sciencedirect.com/science/article/pii/S154431911930514XState medical cannabis laws. (2022).https://www.ncsl.org/research/health/state-medical-marijuana-laws.aspxWarning letters. (2021).https://www.fda.gov/inspections-compliance-enforcement-and-criminal-investigations/compliance-actions-and-activities/warning-lettersWhat you need to know (and what we're working to find out) about products containing cannabis or cannabis-derived compounds, including CBD. (2020).https://www.fda.gov/consumers/consumer-updates/what-you-need-know-and-what-were-working-find-out-about-products-containing-cannabis-or-cannabisFEEDBACK:Medically reviewed by Eloise Theisen, RN, MSN, AGPCNP-BC — By Kristina Iavarone and Anne deLeeuw — Updated on June 23, 2022 Latest newsWhat sets 'SuperAgers' apart? Their unusually large neuronsOmega-3 may provide a brain boost for people in midlifeSeasonal affective disorder (SAD): How to beat it this fall and winterCDC: Monkeypox in the US 'unlikely to be eliminated in the near future'Why are more women prone to Alzheimer's? New clues arise Related Coverage13 of the best CBD oils 2022Medically reviewed by Dominique Fontaine, BSN, RN, HNB-BC, HWNC-BC Studies indicate that CBD is useful for a variety of ailments, and oil is just one of its many forms. Read more about some of the best CBD oils.READ MORE13 of the best CBD gummies of 2022: Comparison, value, tasteMedically reviewed by Dominique Fontaine, BSN, RN, HNB-BC, HWNC-BC CBD gummies are a form of cannabidiol edible. These are foods containing CBD, a compound that comes from the cannabis plant. Learn about the best CBD…READ MOREWhat are CBD crystals?Medically reviewed by Dominique Fontaine, BSN, RN, HNB-BC, HWNC-BC CBD crystals, also known as CBD (cannabidiol) isolate, are the isolated form of CBD, which is a compound from the cannabis plant. Learn more here.READ MORE9 herbs for anxietyMedically reviewed by Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT Anxiety medications can cause unwanted side effects, so some people consider herbal remedies as alternatives. Read more about these potential remedies…READ MORE5 of the best CBD creams for back pain in 2022Medically reviewed by Eloise Theisen, RN, MSN, AGPCNP-BC What are some of the top CBD creams for back pain? Learn about CBD, which CBD creams may be useful for back pain, and alternative treatment options.READ MORE