Apretude: Dosage, cost, uses, and more Health ConditionsHealth ConditionsAlzheimer's & DementiaAnxietyArthritisAsthma & AllergiesBreast CancerCancerCardiovascular HealthCOVID-19Dermatology & SkincareDiabetesEnvironment & SustainabilityExercise & FitnessEye HealthHeadache & MigraineHealth EquityHIV & AIDSHuman BiologyInflammatory Bowel DiseaseLeukemiaLGBTQIA+Men's HealthMental HealthMultiple Sclerosis (MS)NutritionParkinson's DiseasePsoriasisSexual HealthWomen's HealthDiscoverNewsLatest NewsOriginal SeriesMedical MythsHonest NutritionThrough My EyesNew Normal HealthPodcastsHow to understand chronic painWhat is behind vaccine hesitancy?The amazing story of hepatitis C, from discovery to cureNew directions in dementia researchCan psychedelics rewire a depressed, anxious brain?Why climate change matters for human healthToolsGeneral HealthDrugs A-ZHealth HubsHealth ToolsBMI Calculators and ChartsBlood Pressure Chart: Ranges and GuideBreast Cancer: Self-Examination GuideSleep CalculatorHealth ProductsAffordable Therapy OptionsBlood Pressure MonitorsDiabetic SuppliesFitness TrackersHome GymsGreen Cleaning ProductsHow to Shop for CBDQuizzesRA Myths vs FactsType 2 Diabetes: Managing Blood SugarAnkylosing Spondylitis Pain: Fact or FictionConnectAbout Medical News TodayWho We AreOur Editorial ProcessContent IntegrityConscious LanguageNewslettersSign UpFollow UsMedical News TodayHealth ConditionsDiscoverToolsConnectSubscribe Apretude cabotegravir Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Helen Marshall, BPharm, MRPharmS on July 20, 2022 What is Apretude Apretude is a brand-name prescription medication. It’s FDA-approved to help prevent HIV in people at risk of contracting HIV through sexual activity. This is called HIV pre-exposure prophylaxis (PrEP). Apretude is approved for HIV PrEP in adults and adolescents ages 12 years and older who weigh at least 35 kilograms* (kg), which is about 77 pounds (lb). Your doctor will only prescribe Apretude for HIV PrEP if you test negative for HIV. * One kg is about 2.2 lb. Drug details Apretude contains the active drug cabotegravir. It comes as a liquid suspension given as an intramuscular injection (an injection into your muscle) by your doctor or healthcare professional. You will receive your injections in your doctor’s office or clinic. For the first two injections, you’ll receive one injection each month. Then, you’ll typically receive one injection every 2 months. Apretude is a long-acting injection. The drug may stay in your body for 12 months or longer after stopping treatment. Your doctor may want to check that cabotegravir doesn’t cause you bothersome side effects before you start treatment with Apretude. In this case, they may recommend taking cabotegravir tablets (Vocabria) for about 1 month before you start Apretude. FDA approval The Food and Drug Administration (FDA) first approved Apretude for PrEP in 2021. Apretude is the first long-acting injection to be approved for PrEP. Effectiveness For information about the effectiveness of Apretude, see the “Apretude uses” section below. Apretude generic Apretude is available only as a brand-name medication. It’s not currently available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics usually cost less than brand-name drugs. Apretude injection dosage Apretude is used for HIV pre-exposure prophylaxis (PrEP). The following information describes dosages that are commonly used or recommended. However, your doctor will determine the best dosage to fit your needs. Drug forms and strengths Apretude comes as a liquid suspension in a single-dose vial. Each vial contains 600 milligrams (mg) of the drug in 3 milliliters (mL) of suspension. Apretude is given as an intramuscular injection. Your doctor or healthcare professional will inject the dose of Apretude into the muscle of your buttock. You will receive your injections in your doctor’s office or clinic. Dosing for HIV PrEP Your doctor may recommend taking cabotegravir tablets (Vocabria) for about 1 month before you start Apretude for PrEP. In this case, you should receive your first Apretude injection on the last day of taking Vocabria or within 3 days after stopping Vocabria. If you don’t take Vocabria before starting Apretude, you can receive your first Apretude injection at any time. Your doctor will test you for HIV before you have your first injection of Apretude for PrEP. They’ll also test you before each following injection. If you test positive for HIV, your doctor won’t administer Apretude. Instead, they’ll prescribe different medications to treat HIV. The recommended dosage of Apretude for PrEP is one injection of 600 mg, followed by a second injection of 600 mg 1 month later. After this, the recommended dosage is one injection of 600 mg every 2 months. Children s dosage Apretude is FDA-approved for HIV PrEP in adolescents ages 12 years and older who weigh at least 35 kilograms* (kg), which is about 77 pounds (lb). The recommended dosing for adolescent children is the same as for adults. This dosage is described above. * One kg is about 2.2 lb. What if I miss a dose If you miss an appointment to receive your dose of Apretude, call your doctor’s office right away to reschedule. The date of your next injection and whether your treatment schedule changes will depend on when you had your last injection. In some cases, your doctor may recommend taking cabotegravir tablets (Vocabria) for up to 2 months to replace a missed injection. Your doctor will recommend the best course of action for your situation. To help make sure that you don’t miss a dose, be sure to put all your appointments on a calendar. You could also try using a medication reminder. This can include setting an alarm. You could also download a reminder app on your phone. Will I need to use this drug long term Apretude is meant to be a long-term treatment. If you and your doctor determine that Apretude is safe and effective for you, you’ll likely take it long term. Apretude cost As with all medications, the price of Apretude can vary. The actual price you’ll pay depends on your insurance plan, your location, and the pharmacy you use. Before approving coverage for Apretude, your insurance company may require you to get prior authorization. This means that your doctor and insurance company will need to communicate about your prescription before the insurance company will cover the drug. The insurance company will review the prior authorization request and decide if the drug will be covered. If you’re not sure whether you’ll need prior authorization for Apretude, contact your insurance company. Financial and insurance assistance If you need financial support to pay for Apretude, or if you need help understanding your insurance coverage, help is available. The Apretude Savings Program may help you save on the cost of Apretude. For more information and to find out if you’re eligible for support, call 844-588-3288 or visit the program website. To learn more about saving money on prescriptions, check out this article. Generic version Apretude is not available in a generic form. A generic drug is an exact copy of the active drug in a brand-name medication. Generics tend to cost less than brand-name drugs. Apretude use for HIV PrEP The Food and Drug Administration (FDA) approves prescription drugs such as Apretude to treat certain conditions. Apretude for HIV PrEP Apretude is FDA-approved for HIV pre-exposure prophylaxis (PrEP) in people at risk of contracting HIV through sexual activity. Apretude is approved for this use in adults and adolescents ages 12 years and older who weigh at least 35 kilograms (kg), which is about 77 pounds (lb). (One kg is about 2.2 lb.) HIV PrEP explained A doctor may prescribe HIV PrEP as a treatment to help prevent HIV. They may recommend it for someone at risk of contracting HIV-1 (the most common form of HIV). This may be because of:having a sexual partner who’s HIV-positivehaving sexual partner(s) who don’t know their HIV statusnot always using condomshaving other sexually transmitted infections (STIs) or having had STIs in the past 6 months Apretude is a long-acting antiretroviral that stops HIV from multiplying. (Antiretrovirals are drugs used to treat or prevent HIV.) If you’re exposed to HIV while you have Apretude in your body, the medication can stop the virus from increasing in numbers. This can prevent it from causing HIV. However, note that Apretude isn’t always effective at preventing HIV. It’s still possible to contract HIV even if you’re receiving Apretude. Your doctor will only prescribe Apretude if you test negative for HIV. They will test you before you start Apretude and before you receive each injection of the drug. (If Apretude is used in people with undiagnosed HIV, the virus could develop resistance to the drug.* This could make HIV harder to treat.) To help lower your risk of contracting HIV while receiving Apretude for PrEP, it’s important to keep all your appointments. You should also use condoms to help prevent HIV and other STIs. During Apretude treatment, it’s important to see a doctor right away to get tested for HIV if you:have sex without a condom or a condom breaks during sexhave symptoms of STIs such as chlamydia or gonorrhea (having an STI can make it easier to contract HIV)develop any early symptoms of HIV, which may include:feverfatiguemuscle achesskin rashvomitingdiarrheanight sweatsheadacheswollen lymph nodes in your neck or groinsore throat If you test positive for HIV while receiving Apretude for PrEP, you’ll need to stop Apretude. Your doctor will switch you to an HIV treatment regimen. To learn more about HIV, you can visit our hub for HIV and AIDS. * Note: Apretude has a boxed warning about the risk of drug resistance. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients to side effects that could be dangerous. Effectiveness for HIV PrEP Clinical trials have confirmed the efficacy of Apretude for HIV PrEP. To find out how the drug performed in these trials, see Apretude’s prescribing information. Apretude is recommended as a treatment option for HIV PrEP in guidelines from the Centers for Disease Control and Prevention (CDC). Apretude and children Apretude is FDA-approved for HIV PrEP in adolescents who weigh at least 35 kilograms (kg), which is about 77 pounds (lb). (One kg is about 2.2 lb.) Apretude side effects Apretude can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Apretude. These lists do not include all possible side effects. Note that Apretude is a long-acting injection. The drug may stay in your body for 12 months or longer after stopping treatment. If you have side effects with Apretude, they may last for a long time. For more information about the possible side effects of Apretude, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be concerning or bothersome. Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Apretude, you can do so through MedWatch. Mild side effects Mild side effects* of Apretude can include:injection site reactions, such as pain, swelling, warmth, redness, discoloration, bruising, hardness, itching, or numbnessdiarrheanausea and vomitingabdominal painflatulence (gas)fatigueheadachedizzinesssleep problems, such as sleepiness, insomnia (trouble sleeping), or unusual dreamsmuscle or back painreduced appetiterashfeverupper respiratory infection, such as the common coldweight gain Most of these side effects may go away within a few days to a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist. * This is a partial list of mild side effects from Apretude. To learn about other mild side effects, talk with your doctor or pharmacist, or view Apretude’s prescribing information. Serious side effects Serious side effects from Apretude aren’t common, but they can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include:Liver damage. Symptoms can include:pain on the right side of your abdomennausea and vomitingpale-colored stoolsdark-colored urineitchingjaundiceDepression. Symptoms can include:feeling sad or hopelessanxiety or irritabilityeating more or less than usualchanges in sleep, such as trouble getting to sleep or waking earlyfatiguelosing interest in activities you used to enjoysuicidal thoughts and behaviorsRisk of drug resistance when used for PrEP in people with undiagnosed HIV.*Allergic reaction. * Apretude has a boxed warning for this side effect. This is a serious warning from the FDA. To learn more, see the “FDA warning” at the top of this article. Suicide prevention If you know someone at immediate risk of self-harm, suicide, or hurting another person:Ask the tough question: “Are you considering suicide?”Listen to the person without judgment.Call 911 or the local emergency number, or text TALK to 741741 to communicate with a trained crisis counselor.Stay with the person until professional help arrives.Try to remove any weapons, medications, or other potentially harmful objects. If you or someone you know is having thoughts of suicide, a prevention hotline can help. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. During a crisis, people who are hard of hearing can use their preferred relay service or dial 711 then 988. Click here for more links and local resources. Side effects in children Apretude is approved for use in adolescents ages 12 years and older who weigh at least 35 kilograms (kg), which is about 77 pounds (lb). (One kg is about 2.2 lb.) In clinical trials, side effects reported in adolescent children were similar to side effects reported in adults receiving Apretude. Examples of these side effects are listed in the section above.ALLERGIC REACTION As with most drugs, some people can have an allergic reaction after taking Apretude. This side effect wasn’t reported in clinical trials of this drug but can still occur. Symptoms of a mild allergic reaction can include:skin rashitchinessflushing A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:swelling under your skin, typically in your eyelids, lips, hands, or feetswelling of your tongue, mouth, or throattrouble breathing Call your doctor right away if you have an allergic reaction to Apretude, as the reaction could become severe. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency. Alternatives to Apretude Other drugs are available for HIV pre-exposure prophylaxis (PrEP). Some may be a better fit for you than others. If you’re interested in finding an alternative to Apretude, talk with your doctor. They can tell you about other medications that may work well for you. Alternatives for HIV PrEP Examples of other drugs that may be used for HIV PrEP include:cabotegravir sodium (Vocabria)emtricitabine and tenofovir alafenamide (Descovy)emtricitabine and tenofovir disoproxil fumarate (Truvada) Common questions about Apretude Here are answers to some frequently asked questions about Apretude. Can Apretude be used to treat HIV No, Apretude can’t be used to treat HIV. The drug is only approved for HIV pre-exposure prophylaxis (PrEP). This means Apretude is only prescribed to help prevent HIV in people who are at risk of contracting HIV through sexual activity. If you test positive for HIV while receiving Apretude, your doctor will switch you to an HIV treatment regimen. To treat HIV, at least two antiretroviral drugs from different classes must be used. (Antiretrovirals are drugs used to prevent and treat HIV.) Apretude only contains one antiretroviral drug, called cabotegravir. To treat HIV, cabotegravir is used in combination with a different antiretroviral called rilpivirine. A medication called Cabenuva contains a long-acting cabotegravir injection and a long-acting rilpivirine injection. Cabenuva is approved to treat HIV. For HIV PrEP how does Apretude compare with Truvada Apretude and Truvada are different medications used for HIV PrEP. Apretude is a long-acting injection that’s typically taken every 2 months. It contains one active drug, cabotegravir. Truvada is an oral tablet that you take once per day. It contains two active drugs, emtricitabine and tenofovir disoproxil fumarate. Apretude was compared with Truvada in two clinical trials. Both trials found Apretude to be more effective than Truvada at preventing HIV. To find out how the drugs performed in these trials, see Apretude’s prescribing information. Apretude and Truvada can cause different side effects. Apretude can remain in your body for 12 months or longer after stopping treatment. So, side effects with Apretude could last much longer than side effects with Truvada. If you’re interested in taking HIV PrEP, talk with your doctor about which medication may be most suitable for you. Can Cabenuva be prescribed as an alternative to Apretude No, Cabenuva can’t be prescribed as an alternative to Apretude. Cabenuva is used to treat HIV, whereas Apretude is used for HIV PrEP. Cabenuva contains two active drugs, a long-acting cabotegravir injection and a long-acting rilpivirine injection. Apretude only contains cabotegravir. If you have questions about alternatives to Apretude, talk with your doctor. How Apretude is given Apretude is given by intramuscular injection. Administration of Apretude is given by a healthcare professional in your doctor’s office or clinic. You’ll receive your Apretude injection in your buttock. When it s given Your doctor may recommend taking cabotegravir tablets (Vocabria) for about 1 month before you start Apretude for HIV pre-exposure prophylaxis (PrEP). In this case, you should receive your first Apretude injection on the last day of taking Vocabria, or within 3 days after stopping Vocabria. If you don’t take Vocabria before starting Apretude, you can receive your first Apretude injection at any time. In both cases, your first two injections of Apretude will be given 1 month apart. After this, you’ll have one injection every 2 months. If you miss an appointment to have a dose of Apretude, call your doctor’s office right away to reschedule. Your doctor will recommend the best course of action for your situation. To help make sure that you don’t miss an appointment to have your dose of Apretude, be sure to put all your appointments on a calendar. You could also try using a medication reminder. This can include setting an alarm. You could also download a reminder app on your phone. Apretude and alcohol Alcohol doesn’t affect the way Apretude works. However, drinking alcohol while you’re receiving Apretude may raise your risk for certain side effects. These include nausea, vomiting, headache, and dizziness. Drinking heavily with Apretude could also raise your risk for liver damage. Both Apretude and drinking large amounts of alcohol can cause liver damage. If you drink alcohol, talk with your doctor about how much is safe to drink while you’re receiving Apretude. Apretude interactions Apretude can interact with several other medications. Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe. Apretude and other medications Below is a list of medications that can interact with Apretude. This list does not contain all drugs that may interact with Apretude. Before taking Apretude, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. Types of drugs that can interact with Apretude include:Certain seizure medications. Certain seizure medications can make Apretude less effective at preventing HIV. For this reason, your doctor will likely not prescribe Apretude if you’re taking any of the following:carbamazepine (Carbatrol, Equetro, Tegretol, others)oxcarbazepine (Trileptal, Oxtellar XR)phenobarbitalphenytoin (Dilantin)Certain antibacterials. Certain antibacterials can make Apretude less effective at preventing HIV. For this reason, your doctor will likely not prescribe Apretude if you’re taking any of the following:rifampin (Rifadin, Rimactane)rifapentine (Priftin)UGT1A1 or UGT1A9 inducers. UGT1A1 and UGT1A9 are enzymes that help break down certain drugs in your body, including Apretude. Drugs that are UGT1A1 or UGT1A9 inducers can speed up the breakdown of Apretude, which can make it less effective at preventing HIV. The drugs listed above are examples of strong UGT1A1 or UGT1A9 inducers. Other examples are listed below. Your doctor may adjust your dosing schedule of Apretude if you take it with one of these drugs:rifabutin (Mycobutin)rifabutin, amoxicillin, and omeprazole (Talicia)Methadone (Methadose). Taking Apretude with methadone could reduce the effect of methadone. Your doctor may adjust your dosage of methadone if you take it with Apretude. Apretude and herbs and supplements There aren’t any herbs or supplements that have been specifically reported to interact with Apretude. However, you should still check with your doctor or pharmacist before using any of these products while taking Apretude. Apretude and foods There aren’t any foods that have been specifically reported to interact with Apretude. If you have any questions about eating certain foods with Apretude, talk with your doctor. How Apretude works Apretude is used to help prevent HIV in people at risk of contracting HIV through sexual activity. This is called HIV pre-exposure prophylaxis (PrEP). HIV is a type of virus called a retrovirus. Apretude is a type of drug called an antiretroviral. Antiretrovirals are drugs used to treat or prevent HIV. Apretude is a type of antiretroviral called an integrase strand inhibitor. It works by blocking the action of integrase, which is one of the enzymes (type of protein) that HIV uses to make new copies of itself. Blocking this enzyme stops HIV from increasing in numbers. If you’re exposed to HIV while you have Apretude in your body, the medication can stop the virus from increasing in numbers. This can prevent it from causing HIV. Apretude is a long-acting injection that’s administered into the muscle of your buttock. The drug is slowly absorbed from the injection site into your bloodstream over a 2-month period. This produces a steady level of the drug in your bloodstream. Note that Apretude isn’t always effective at preventing HIV. It’s still possible to contract HIV even if you’re receiving Apretude. It’s important to use condoms to help protect you from HIV and other sexually transmitted infections. How long does it take to work Apretude starts working to prevent HIV soon after you receive your first injection. However, it takes about 7 days for the drug to reach its maximum level in your bloodstream. Apretude and pregnancy It’s not known if Apretude is safe to take during pregnancy. The drug hasn’t been studied in people who are pregnant. One clinical study found that a drug from the same class as Apretude, called dolutegravir (Tivicay), may raise the risk of congenital anomalies (commonly known as birth defects) when used during pregnancy. But this doesn’t mean that Apretude may also have this effect. In animal studies, researchers looked at the effect of giving oral cabotegravir (the active drug in Apretude) to pregnant females. In some studies, doses of cabotegravir higher than those used in humans had harmful effects on the fetus. But in other studies, no harmful effects were seen. Note that animal studies don’t always predict what may happen in humans. If you’re pregnant or plan to become pregnant, talk with your doctor about the pros and cons of receiving Apretude. Note that Apretude is a long-acting injection, and the drug can remain in your body for 12 months or longer after stopping treatment. If you take Apretude during pregnancy, you’re encouraged to sign up for the Antiretroviral Pregnancy Registry. This registry monitors the health of pregnant people who take antiretrovirals (drugs to treat or prevent HIV) and their babies. It aims to help healthcare professionals find out how safe antiretroviral drugs are for use during pregnancy. To find out more, talk with your doctor or refer to the pregnancy registry website. Apretude and birth control It’s not known if Apretude is safe to take during pregnancy. If you’re sexually active and you or your partner can become pregnant, talk with your doctor about your birth control needs while you’re using Apretude. For more information about taking Apretude during pregnancy, see the “Apretude and pregnancy” section above. Apretude and breastfeeding It isn’t known if Apretude is safe to take while breastfeeding. It’s unknown if the drug can pass into breast milk. If you’re breastfeeding or plan to breastfeed, talk with your doctor about the risks and benefits of receiving Apretude. Note that Apretude is a long-acting injection, and the drug can remain in your body for 12 months or longer after stopping treatment. Apretude precautions This drug comes with several precautions. FDA warning Risk of drug resistance when used for PrEP in people with undiagnosed HIV This drug has a boxed warning. This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous. Apretude should only be used for HIV pre-exposure prophylaxis (PrEP) in people who test negative for HIV. If Apretude is used in people with undiagnosed HIV, the virus could develop resistance to the drug. This could make the HIV harder to treat. Your doctor will test you for HIV before you start Apretude and before you receive each injection of the drug. If you test positive for HIV while receiving Apretude for PrEP, you’ll need to stop Apretude. Your doctor will switch you to an HIV treatment regimen. To learn more, see the “FDA warning” at the top of this article. Other precautions Before taking Apretude, talk with your doctor about your health history. Apretude may not be right for you if you have certain medical conditions or other factors affecting your health. These include:Allergic reaction. If you’ve had an allergic reaction to Apretude or any of its ingredients, your doctor will likely not prescribe it. Ask your doctor about other medications that may be better options for you.Mental health problems. In rare cases, Apretude may cause depression. If you have a history of mental health problems, such as depression, talk with your doctor about whether Apretude is right for you. If your doctor prescribes Apretude, see them right away if you have any new or worsening changes in your mood, thoughts, or behavior.Liver disease. Although rare, Apretude may cause liver damage. If you have liver disease, this could make your condition worse. Talk with your doctor about whether Apretude is right for you. If your doctor prescribes Apretude, they’ll likely monitor your liver function during treatment. If you have worsening liver problems, you’ll likely need to stop Apretude.Pregnancy. It’s not known if Apretude is safe to use during pregnancy. For more information, see the “Apretude and pregnancy” section above.Breastfeeding. It’s not known if Apretude can pass into breast milk. For more information, see the “Apretude and breastfeeding” section above. Note: For more information about the potential negative effects of Apretude, see the “Apretude side effects” section above. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.HIV and AIDSPharmacy / PharmacistDrugsMedically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Helen Marshall, BPharm, MRPharmS on July 20, 2022 Latest newsWhat sets 'SuperAgers' apart? Their unusually large neuronsOmega-3 may provide a brain boost for people in midlifeSeasonal affective disorder (SAD): How to beat it this fall and winterCDC: Monkeypox in the US 'unlikely to be eliminated in the near future'Why are more women prone to Alzheimer's? 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