What are some of the best medications for diarrhea? 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It can result in dehydration and malnutrition, so it is important to relieve diarrhea with suitable treatment as soon as possible. Diarrhea is when stool contains too much water, causing runny stool. Diarrhea occurs when the small and large intestine cannot absorb ions, such as salt. As a result, the intestines are also unable to absorb water into the body, leading to watery stools. Diarrhea can be either acute or chronic. Acute diarrhea typically refers to passing at least three loose stools a day for up to 14 days. A doctor may describe diarrhea lasting between 2 and 4 weeks as persistent and cases lasting longer than 4 weeks as chronic diarrhea. In most cases, the condition resolves within 4 days. Common causes of diarrhea can include:traveler’s diarrhea, or food poisoningside effects of medicationfood allergies and intolerancesdigestive issuesinfection There are three types of infection that can cause diarrhea:viral infection, such as norovirus, rotavirus, or viral gastroenteritisbacterial infection, such as salmonella or campylobacterparasitic infection, such as giardiasis or cryptosporidiosis Depending on the cause, different medications are available for diarrhea. Typically, treatment options involve regulating gastrointestinal movement and increasing fluid absorption in the intestines. In this article, we will discuss medications that can help relieve diarrhea. Over-the-counter OTC medication Share on PinterestComezora/Getty ImagesOTC medications are available for acute diarrhea. However, if symptoms persist, a person may require different treatment to target whatever is causing it. Common medications for diarrhea include loperamide and bismuth subsalicylate. Loperamide Loperamide, which people commonly refer to as its brand name, Imodium, is an anti-diarrheal agent that treats diarrhea by affecting the opiate receptors in the intestine. This drug works by slowing the contractions of the intestines and how quickly its contents pass through. By slowing the movement, it allows more time for water reabsorption. Potential side effects of loperamide can include:dry mouthnauseapassing windstomach crampsileus, a temporary lack of muscle contraction in the intestineconstipationdizzinesstirednessdifficulty emptying urine from the bladder It is also worth noting that loperamide is not a controlled substance, and there is a risk of overdosage and severe adverse reactions. As such, the recommended usage for adults and those 13 years and older is an initial dose of 4 milligrams (mg) or 2 capsules, then 2 mg or 1 capsule after each loose stool. It is not advisable to exceed 16 mg or 8 capsules per day. Bismuth subsalicylate Bismuth subsalicylate, which people know by the brand names Kaopectate and Pepto-Bismol, is another OTC medication for treating diarrhea. As the drug passes into the stomach, it divides into bismuth and salicylic acid as two separate compounds. The bismuth remains in the stomach, where it helps increase fluid absorption, reduce inflammation, and heal the stomach. The bismuth can do this due to its bactericidal and antimicrobial activity that can inhibit the pathogens causing diarrhea. Bismuth subsalicylate may cause the following side effects:nauseabitter tastedark or black stool As this drug contains salicylate, it is not advisable for people with allergies, such as aspirin, to use bismuth salicylate. Additionally, this drug may interact with other medications. As such, it is advisable to consult a doctor before using it if a person takes any drugs for:anticoagulationdiabetesgoutarthritis Prescription Prescription medication is generally more specific to the cause of diarrhea. These types of medication can include the following:alosetroneluxadolinerifaximin Alosetron Alosetron is a form of treatment for individuals with severe diarrhea-predominant irritable bowel syndrome (IBS-D). It blocks the receptors that cause pain, abdominal discomfort, and diarrhea. Side effects of alosetron can include constipation and ischemic colitis, which reduces blood flow to the large intestine. Eluxadoline Eluxadoline, available under the brand name Viberzi, is another treatment for IBS-D. This medication affects opioid receptors and manages symptoms by regulating gastrointestinal movement, secretion, and discomfort. It causes fewer side effects than alosetron, but more studies are necessary to determine its effectiveness compared with other medications. Rifaximin Rifaximin, which has the brand name Xifaxan, is a form of treatment for both IBS-D and traveler’s diarrhea. It is an antibiotic, so it is important to make sure the person taking it has not contracted viral diarrhea. Rifaximin works by fighting gram-negative and gram-positive anaerobic and aerobic bacteria, so it can treat a range of cases. Who should not take diarrhea medications Some people should avoid taking diarrhea medications. For example, OTC diarrhea medications can be dangerous for:infantstoddlersyoung children Additionally, people should avoid OTC medication if there is blood present in their stool, the person has a fever, or there are other signs of either bacterial or parasitic infection. If diarrhea persists for more than 2 days, it is advisable to consult a doctor. Individuals should always make sure any medication they take does not contain an ingredient that may cause an allergic reaction. If they are unsure, they can check with a doctor or pharmacist. Additionally, someone who is pregnant should check with a healthcare professional before taking new medication. Other options Diarrhea causes a risk of dehydration and, in long-term cases, malnutrition. The first step of treatment is to try to replace the fluids and electrolytes that are leaving the body. People can use sports drinks that contain salts and sugars to help promote water absorption. If the body is still unable to absorb water, intravenous fluid replacement may be necessary. To make the stool less runny, a person may consider consuming low fiber foods or following the BRAT diet. BRAT stands for bananas, rice, applesauce, and toast. The bland diet, which includes more foods but still minimizes fiber, spice, and high consistency foods, may also be useful for people with diarrhea symptoms. However, as these diets may be low in nutritional value and calories, some health experts no longer recommend them. Click here to learn more about what to eat and drink when experiencing diarrhea. Prevention Washing hands regularly and thoroughly is important for preventing the spread of infectious diarrhea. If a person has acute diarrhea, they should stay home and avoid going to public places, such as school or work, until their symptoms resolve. Vaccination is available against rotavirus, a common infectious cause of diarrhea. In areas where food and water are more likely to contain harmful pathogens, it is better to avoid tap water and drink water from bottles instead. Before buying bottled water, people should check the seal to ensure it is still intact. It may also be advisable to avoid raw vegetables and fruits and stick to well-cooked meals that have not been sitting on a buffet. To prevent dehydration from diarrhea, people can use oral rehydration therapy or electrolyte drinks as soon as they notice symptoms. Summary Diarrhea typically refers to when people pass watery stool at least three times a day. There are different possible causes of diarrhea, and the condition can be acute or chronic, depending on how long it persists. Without treatment, the condition can result in severe complications. As such, it is advisable to use medications to help relieve symptoms of diarrhea. Both OTC and prescription options are available, which aim to slow the passage of contents through the intestines and increase the absorption of fluids. In many cases, diarrhea resolves within a few days. However, if symptoms persist for more than 2 days, it is advisable to contact a doctor. Last medically reviewed on August 10, 2022GastroIntestinal / GastroenterologyInfectious Diseases / Bacteria / Viruses 16 sourcescollapsedMedical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. We avoid using tertiary references. We link primary sources — including studies, scientific references, and statistics — within each article and also list them in the resources section at the bottom of our articles. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Alosetron hydrochloride tablet, film coated. (2022). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=ba94ab71-11d7-4ce1-9b21-0b8c6a39e993Bismuth subsalicylate capsule, gelatin coated. (2021). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=dfb5ed78-99b5-4c8e-a36c-5e4c32fa021eBudisak, P., et al. (2022). Bismuth subsalicylate. https://www.ncbi.nlm.nih.gov/books/NBK560697/Butt, I., et al. (2022). Alosetron. https://www.ncbi.nlm.nih.gov/books/NBK553080/Diarrhea. (n.d.). https://www.niddk.nih.gov/health-information/digestive-diseases/diarrheaLoperamide. (2019). https://www.ncbi.nlm.nih.gov/books/NBK547935/Loperamide hydrochloride capsule. (2022). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=72a7ae47-cdf3-4949-b9f8-f29b153f787fMaltz, F., et al. (2017). Eluxadoline (Viberzi). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5481293/Nemeth, V., et al. (2021). Diarrhea. https://www.ncbi.nlm.nih.gov/books/NBK448082/Robertson, K. D., et al. (2022). Rifaximin. https://www.ncbi.nlm.nih.gov/books/NBK562329/Rotavirus vaccination. (2018). https://www.cdc.gov/vaccines/vpd/rotavirus/index.htmlSahi, N., et al. (2022). Loperamide. https://www.ncbi.nlm.nih.gov/books/NBK557885/Traveler's diarrhea. (2022). https://wwwnc.cdc.gov/travel/page/travelers-diarrheaViberzi - eluxadoline tablet, film coated. (2020). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=7821bd40-4c84-4984-951b-6436ae20421aWeir, S.-B. S., et al. (2021). Bland diet. https://www.ncbi.nlm.nih.gov/books/NBK538142/Xifaxan - rifaximin tablet. (2021).https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f73acb74-e930-4414-81e9-d2a01db36e30FEEDBACK:Medically reviewed by Alexandra Perez, PharmD, MBA, BCGP — By Helen Millar on August 10, 2022 Latest newsWhat sets 'SuperAgers' apart? Their unusually large neuronsOmega-3 may provide a brain boost for people in midlifeSeasonal affective disorder (SAD): How to beat it this fall and winterCDC: Monkeypox in the US 'unlikely to be eliminated in the near future'Why are more women prone to Alzheimer's? New clues arise Related CoverageWhat you should know about diarrheaMedically reviewed by Cynthia Taylor Chavoustie, MPAS, PA-C Diarrhea, which refers to unusually loose or watery stools, is a common problem with many potential causes. Several treatments can help. Learn more…READ MOREHow to treat diarrhea at homeMedically reviewed by J. Keith Fisher, M.D Diarrhea is a common digestive problem. 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