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Duke, PharmD, RPh — By Jennifer Mitri Williamson, Pharm.D. on September 24, 2022 Overview Inflectra (infliximab-dyyb)* is a brand-name prescription medication. The Food and Drug Administration (FDA) has approved it to treat the following conditions in adults:Crohn’s diseaserheumatoid arthritisplaque psoriasispsoriatic arthritisulcerative colitisankylosing spondylitis In addition, Inflectra can also be used to treat Crohn’s disease or ulcerative colitis in children ages 6 years and older. Inflectra comes as a powder that’s mixed into a solution and given as an IV infusion by your doctor or another healthcare professional. It belongs to a class of drugs called tumor necrosis factor blockers. Inflectra is available only as a brand-name medication. It’s not available as a generic version at this time. However, Inflectra is a biologic drug. It contains the active ingredient infliximab-dyyb, which is a biosimilar form of the drug Remicade. For information about the dosage of Inflectra, including its strength and how to take the drug, keep reading. For a comprehensive look at Inflectra, see this article. This article describes typical dosages for Inflectra provided by the drug’s manufacturer. * The reason “-dyyb” appears at the end of the drug’s name is to show that the drug is distinct from similar medications that may be created in the future. Inflectra dosage Your doctor will prescribe the best infusion dosage of Inflectra for you. They may recommend a dosing schedule to help keep track of your Inflectra doses. Inflectra form Inflectra comes as a powder that’s mixed into a solution and given as an IV infusion by your doctor or another healthcare professional. Inflectra strength Inflectra comes in one strength: 100 milligrams (mg). Typical dosages Inflectra’s dosage will be calculated based on your body weight. So before you start treatment, your doctor will determine the best infusion dosage for you. Your doctor will ultimately prescribe the smallest dosage that provides the desired effect. The following information describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs. Dosage for Crohn s disease The recommended dosage of Inflectra for Crohn’s disease in adults is 5 milligrams per kilogram* of body weight (mg/kg). For example, if you weigh 80 kg (about 176 pounds), your dose of Inflectra will be 400 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 8 weeks. In some cases, your doctor may recommend increasing your dose up to a maximum of 10 mg/kg once every 8 weeks. Your doctor can help determine the best infusion dosing for you. Dosage for rheumatoid arthritis The recommended dose of Inflectra to treat rheumatoid arthritis in adults is 3 mg/kg. So if you weigh 80 kg (about 176 pounds), your dose will be 240 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 8 weeks. If you take Inflectra for rheumatoid arthritis, your doctor will recommend taking your dose in combination with another medication called Trexall (methotrexate). This drug works along with Inflectra to help treat your condition. In some cases, your doctor may recommend increasing your dose up to a maximum of 10 mg/kg once every 4 or 8 weeks. Your doctor can help recommend the best dosage of Inflectra to treat your condition. Dosage for plaque psoriasis The recommended dose of Inflectra to treat plaque psoriasis in adults is 5 mg/kg. So if you weigh 80 kg (about 176 pounds), your dose will be 400 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 8 weeks. Dosage for psoriatic arthritis The recommended dose of Inflectra to treat psoriatic arthritis in adults is 5 mg/kg. So if you weigh 80 kg (about 176 pounds), your dose will be 400 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 8 weeks. Your doctor may recommend taking Inflectra alone or in combination with Trexall (methotrexate) to treat psoriatic arthritis. Dosage for ulcerative colitis The recommended dose of Inflectra to treat ulcerative colitis in adults is 5 mg/kg. So if you weigh 80 kg (about 176 pounds), your dose will be 400 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 8 weeks. Dosage for ankylosing spondylitis The recommended dose of Inflectra to treat ankylosing spondylitis in adults is 5 mg/kg. So if you weigh 80 kg (about 176 pounds), your dose will be 400 mg. After your first dose of medication, you’ll receive Inflectra again at weeks 2 and 6. Then, after your third dose of medication, you’ll receive one dose of Inflectra every 6 weeks. * 1 kg is equal to about 2.2 pounds. Children s dosage Inflectra is also approved to treat Crohn’s disease or ulcerative colitis in children ages 6 years and older. This medication is not approved for use in children with other conditions. Dosage for Crohn s disease in children The recommended dosage of Inflectra for Crohn’s disease in children is 5 milligrams per kilogram* of body weight (mg/kg). So if your child weighs 30 kg (about 66 pounds), their dose will be 150 mg. After the first dose of Inflectra, your child will receive a dose of medication at weeks 2 and 6. Then, after their third dose of medication, they’ll receive one dose of Inflectra every 8 weeks. Dosage for ulcerative colitis in children The recommended dosage of Inflectra for ulcerative colitis in children is 5 mg/kg of body weight. So if your child weighs 30 kg (about 66 pounds), their dose will be 150 mg. After the first dose of Inflectra, your child will receive a dose of medication at weeks 2 and 6. Then, after their third dose of medication, they’ll receive one dose of Inflectra every 8 weeks. * 1 kg is equal to about 2.2 pounds. Long-term treatment Inflectra is meant to be a long-term treatment. If you and your doctor determine that Inflectra is safe and effective for you, you’ll likely take it long term. Frequently asked questions Below are some frequently asked questions about Inflectra. Will my doctor use a dosing calculator for Inflectra It’s possible that your doctor may use a dosing calculator to determine the best dosage of Inflectra for you. Your dose of Inflectra is calculated using your body weight. So your doctor will calculate the best dose for you based on your condition and your body weight. What s the Inflectra dosage for sarcoidosis Inflectra is not approved to treat people with sarcoidosis at this time. So there isn’t a recommended dose of this medication for people with sarcoidosis. However, this drug is being studied to treat sarcoidosis. One study shows that the drug can be effective in certain people with sarcoidosis. At this time, it hasn’t been approved by the FDA for use in people with this condition. It’s possible for your doctor to recommend taking Inflectra off-label to treat sarcoidosis. Taking a medication off-label is when an FDA-approved drug is prescribed for a purpose other than what it’s approved for. In this case, your doctor can determine the best dosage for you. How Inflectra is administered Inflectra comes as a powder that’s mixed into a solution and given as an IV infusion by your doctor or another healthcare professional. You will typically receive your dose of Inflectra at a doctor’s clinic or an infusion center. It’s also possible to receive your Inflectra doses at home. In this case, a healthcare professional will come to your home to give your dose. Inflectra infusions typically take at least 2 hours or more. Your doctor may recommend that you take medications before your Inflectra infusion. Examples of these drugs can include Tylenol (acetaminophen) or Benadryl (diphenhydramine). These drugs can be given to decrease the risk of side effects that you may have from receiving Inflectra. Throughout your infusion, your doctor or healthcare professional will monitor you for symptoms of side effects. In some cases, if you develop side effects, they may slow down your Inflectra infusion. If your side effects are severe, they may stop your treatment. Factors that can affect your dosage The Inflectra dosage your doctor prescribes will depend on several factors. These include:the type and severity of the condition you’re using Inflectra to treatyour body weighthow well Inflectra works to treat your symptoms Other medical conditions you have can also affect your Inflectra dosage. Missed dose If you miss your appointment for your dose of Inflectra, call your doctor’s office right away. They can help you schedule another appointment as soon as possible. To help make sure that you don’t miss an appointment for your dose, try using a medication reminder. This can include setting an alarm or using a timer. You could also download a reminder app on your phone. Takeaway and helpful resources The dosages in this article are typical dosages provided by the drug manufacturer. If your doctor recommends Inflectra for you, they will prescribe the dosage that’s right for you. If you have questions about the dosage of Inflectra that’s best for you, talk with your doctor. Besides learning about dosage, you may want other information about Inflectra. These additional articles might be helpful to you:More about Inflectra. For information about other aspects of Inflectra, refer to this article.Side effects. To learn about side effects of Inflectra, see this article. You can also look at the Inflectra prescribing information.Drug comparison. To find out how Inflectra compares with Remicade, read this article.Details about your condition. For details about your condition, see our arthritis hub and psoriasis hub. Also, our Inflammatory bowel disease hub has information on both Crohn’s disease and ulcerative colitis. Disclaimer: Medical News Today has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Last medically reviewed on September 24, 2022PsoriasisPsoriatic ArthritisRheumatoid ArthritisRheumatologyUlcerative ColitisGastroIntestinal / GastroenterologyPharmacy / PharmacistDrugsMedically reviewed by Brittany A. Duke, PharmD, RPh — By Jennifer Mitri Williamson, Pharm.D. on September 24, 2022 Latest newsWhat sets 'SuperAgers' apart? 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