Aivi Nguyen M D - Doctors and Medical Staff - Mayo Clinic
COVID-19 Advice updates and vaccine options
Find out about COVID-19, COVID-19 vaccines, and Mayo Clinic patient and visitor updates. Skip to site navigation Skip to Content This content does not have an English version.This content does not have an Arabic version. Search Request an Appointment Find a Doctor Find a Job Give Now Log in to Patient Account English Español العربية 简体中文 Twitter Facebook Pinterest YouTube Menu Request an Appointment Aivi Nguyen M D
Pathologist Departments
Laboratory Medicine and Pathology Specialty Groups
Neuroimmunology Location
Rochester Minnesota Languages
English Existing patients
Send a secure message via patient portal Share this page via: Facebook Twitter Print Biographical summary
Aivi Nguyen M D , is a practicing board-certified neuropathologist and translational neuropathology researcher, with special focus in neurodegenerative diseases. Dr. Nguyen is an actively contributing neuropathologist to Mayo Clinic's Alzheimer's Disease Research Center (ADRC) and Mayo Clinic Study of Aging (MCSA), both of which involve the study and characterization of aging individuals over time by integrating multidisciplinary efforts, including neuroimaging, CSF biomarkers, and neuropathology. Dr. Nguyen is also involved in multiinstitutional collaborative research efforts. Her primary research interest includes the role of neuroinflammation, specifically microglia, in normal aging and neurodegeneration. Conditions treated
Neurodegeneration Interests
Microglia Heterogeneity in Alzheimer's Disease (AD). During her post-doctoral training, Dr. Nguyen helped characterize the heterogeneous microglial response in human AD brain tissue using single-nuclei RNA sequencing paired with immunohistochemical validation in an autopsy cohort. This continues to be an active area of research, as Dr. Nguyen seeks to understand the interplay between these distinct microglial subpopulations and activation states during differing stages of AD.Genetics and Microglia. Dr. Nguyen is keenly interested in how AD genetic risk variants, e.g., APOE E4 and TREM2 R47H, amongst others, influence the microglial response to proteinopathy in the human brain. Dr. Nguyen and colleagues are actively working to identify how genetic risk dictates the varying microglial activation states in AD.Cognition and Microglia. The rate of cognitive decline may not correlate with levels of pathology, as determined by combined neuropsychiatry data and in vivo neuroimaging studies. Dr. Nguyen and colleagues are employing a multidisciplinary approach integrating neuroimaging, neuropsychiatry, and neuropathology to understand whether microglia plays a role in cognitive resilience. Mayo Clinic locations
Rochester Minnesota
Driving directions More info
Billing & insurance Accessibility services Education
2020Post Doctoral Fellowship - Translational Neuropathology Research Laboratory (TNRL), Dr. Edward B. Lee labSchool of Medicine, University of Pennsylvania2018Fellowship - Neuropathology FellowshipHospital of the University of Pennsylvania2016Resident - Anatomic Pathology ResidencyHospital of the University of Pennsylvania2014MDJefferson Medical College2013Research Fellowship - Medical Research Scholars Program FellowshipNational Institutes of Health2009BS - Cell and Molecular Biology, Genetics (Honors Degree with Distinction)University of DelawareShow more education Activities and honors
Certifications
2018Anatomic PathologyAmerican Board of Pathology2018NeuropathologyAmerican Board of Pathology Awards and honors
2021Diagnostic Slide Session Award for the Best Neurodegenerative CaseAmerican Association of Neuropathology2020Neurodegenerative Disease Scholars Program AwardAmerican Association of Neuropathology2020Robert Terry Award, Honorable mention American Association of Neuropathology2018Diagnostic Slide Session Award for Best Neurodegenerative CaseAmerican Association of Neuropathology2015Penn Cares Grant, "Woodland Writers" ProjectUniversity of Pennsylvania2014The Harold L. Stewart, M.D.,’26 Prize in Pathology Jefferson Medical College2009Imperial College of London-University of Delaware Research Travel AwardUniversity of Delaware and Imperial College of London2008Howard Hughes Medical Institute Research Summer ScholarshipHoward Hughes Medical Institute, University of Delaware2007Howard Hughes Medical Institute Research Summer ScholarshipHoward Hughes Medical Institute, University of Delaware2005Gold Key Scholastic Award - Alliance for Young Artists and WritersGold Key Honor SocietyShow more awards and honors Professional memberships
2020Junior MemberAmerican Association of Neuropathology2020 - presentMemberNew York Academy of Sciences (NYAS)2016Trainee MemberUnited States and Canadian Academy of Pathology2014MemberCollege of American Pathologists2007 - 2009PresidentVietnamese Student Association, University of Delaware2005 - 2009PresidentVietnamese Student Association (VSA)Show more professional memberships Publications
See my publications Biographical summaryConditions treatedInterestsMayo Clinic locationsEducationActivities and honors Request an appointment PST-20515025 Doctors & Medical Staff Nguyen, Aivi M.D.