Endocrinology Clinical trials Mayo Clinic
Endocrinology - Clinical trials - Mayo Clinic
60 studies in Endocrinology
(open studies only). Filter this list of studies by location, status and more.
1. Resistance Training Group: Participants put into the resistance training program will take part in a personalized resistance training program and meet with a personal trainer four times a week for three months. Following the three months of resistance training participants will repeat the baseline visits and will be completed with the study.
2. Control Group: Participants put into the control group are asked not to make any lifestyle changes for 3 months. Following the 3 months, they will come back for a repeat of the baseline measurements. At this point they will have the choice to take part in the resistance training program, followed by a third set of baseline measurements. Remuneration is provided. Study title: Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
IRB #: 19-006273
Principle Investigator: Dr. K Sreekumaran Nair
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Clinical trials
Below are current clinical trials.60 studies in Endocrinology
(open studies only). Filter this list of studies by location, status and more.
A Study to Evaluate the Safety and Effectiveness of Crinecerfont in Adults with Classic Congenital Adrenal Hyperplasia
Rochester, Minn. The purpose of this study is to evaluate the effectiveness of NBI-74788 (100 mg twice daily [bid]), compared with placebo, in reducing daily glucocorticoid dosage while maintaining adrenal androgen control, in reducing adrenal steroid levels following an initial 4-week treatment period, on clinical endpoints associated with supraphysiologic (greater than normal) glucocorticoid dosing, to evaluate plasma concentrations of NBI-74788 and metabolites, and to assess the safety and tolerability of NBI-74788.A Study to Test How Muscle Tissue Differs Between People
Rochester, Minn. The purpose of this study is to look for ways to test how muscle tissue differs between people.A Study to Evaluate Cellular Senescence with Senolytics to Improve Skeletal Health in Older Humans
Rochester, Minn. The purpose of this study is to test whether intermittent senolytic therapy reduces markers of biological age and improves bone turnover markers and skeletal parameters in older postmenopausal women.Insulin Regulation of Lipolysis and Lipolysis Proteins
Rochester, Minn. The purpose of this study is to determine whether impaired insulin-induced suppression of lipolysis (as measured by IC50) is related to lipolysis proteins in groups of volunteers known to vary widely with regards to abdominal adipocyte size and regulation of adipose tissue lipolysis, and whether the improved insulin regulation of lipolysis resulting from treatment with the PPARγ agonist pioglitazone, with or without weight loss, can be linked to specific changes in sets of PPARγ-responsive adipocyte lipolysis proteins in UBO adults.Pediatric Obesity Weight Evaluation Registry POWER Study
Rochester, Minn. The main objective of this study is to establish a national pediatric obesity registry known as POWER (Pediatric Obesity Weight Evaluation Registry). This registry will contain clinical data from individual comprehensive pediatric weight management programs around the United States for overweight and obese youth.Metformin Effect on Brain Function in Insulin Resistant People aged 60
Rochester, Minn. The purpose of this study is to better understand the link between insulin resistance and dementia. Earlier studies have shown that people with insulin resistance are two to four times more likely to develop Alzheimer's disease and other dementias. Other studies have shown a link between the drug Metformin (the most widely used medication to treat prediabetes and type 2 diabetes) and a reduction in the development of dementia. The aim of this study is to investigate if 40 weeks of Metformin treatment (in people 60+ years) enhances brain function and how brain function interacts with the body's metabolism in people with insulin resistance and in people without insulin resistance. Insulin is a hormone produced by the pancreas that deals with sugar (glucose) in the blood. When we eat food, blood sugar levels increase, and the pancreas produces more insulin to keep blood sugar levels stable. If blood sugar decreases, then insulin levels decrease. If the body becomes resistant to insulin, then the body requires more insulin to balance out blood sugar levels. If this continues, eventually the pancreas is not able to produce the amount of insulin needed to balance out blood sugar leading to an elevated fasting blood sugar (fasting blood glucose value greater than 100 mg/dL). Insulin resistance is a primary risk factor for developing type 2 diabetes, heart disease, and dementia. This study is recruiting two groups of people: people with insulin resistance and people without insulin resistance. To qualify for the insulin resistance group, a person would need to have an elevated fasting blood sugar test between 100mg/dL and 140mg/dL. To qualify for the non-insulin resistant group a person would need a blood sugar under 95mg/dL. In people with insulin resistance the study will be measuring changes in brain functions, cognitive ability, and body's metabolism. These series of tests are performed twice, once before and once after 40 weeks of taking Metformin. Brain functions are measured through a series of brain scans. Cognitive ability is measured using computerized tests. To measure the body's metabolism, we measure insulin resistance during an overnight stay, blood tests to measure biomarkers, capacity for exercise, body composition scans, and muscle will be assessed from needle muscle biopsies. In people without insulin resistance, the study will be collecting baseline measurements on brain function, cognitive ability, and body's metabolism. These tests are performed once. Brain functions are measured through a series of brain scans. Cognitive ability is measured using computerized tests. To measure the body's metabolism, we measure insulin resistance during an overnight stay, blood tests to measure biomarkers, and a body composition scan. Remuneration and a travel reimbursement are provided.A Study to Evaluate Innovative Application for Personalized Diabetes Care
Scottsdale/Phoenix, Ariz. The multi-purpose of this study is to examine the effectiveness of “InsulisiteGuider” in patients with type 1 diabetes (T1D) through a two-group randomized controlled trial, to characterize the RNA biomarkers in skin epithelial cells isolated from the continuous subcutaneous insulin infusion (CSII) cannulas from T1D patients, and to characterize RNA biomarkers in the blood and saliva of TID patients.Eosinophils in Human Adipose Tissue
Scottsdale/Phoenix, Ariz. This study aims to assess adipose tissue-eosinophil content and adiopose tissue metabolism 3 months after endoscopic gastroplasty weight loss procedure.A Study to Evaluate Copeptin as a Biomarker for Central Diabetes Insipidus Development Following Pituitary Surgery
Rochester, Minn. The purpose of this study is to investigate if a blood test measuring copeptin within 24 hours following pituitary surgery could predict development of diabetes insipidus (increased urination and thirst with fluid balance problems) as opposed to the clinical methods we currently use.A Study to Evaluate Molecular Mechanisms of Exercise Benefits in Insulin Resistant People
Rochester, Minn. The aim of the study is to investigate the effects of a 3-month resistance exercise program (in people aged 50 to 75) on muscle mass, body composition, muscle strength, brain function and cognition, muscle efficiency processing blood sugar, the body’s ability to build muscle, and fat cells. Earlier research has shown that exercise has significant benefits in preventing certain diseases and conditions such as diabetes, dementia, heart disease, and more. We also know from other research that resistance exercise (lifting weights) and aerobic exercise (running, biking, walking), improve metabolism through separate ways on the molecular level, also called “molecular pathways.” With new and sophisticated technologies, we can analyze these molecular pathways to learn how exercise improves health. The purpose of the study is to understand why resistance exercise can prevent disease though analyzing the ‘molecular pathways’ in correlation with blood sugar to understand its effects on diabetes. We also will correlate these results with brain scan and cognitive tests to understand the mechanisms behind cognitive decline and dementia. Participants in this study will undergo a series of baseline measurements including but not limited to blood tests, brain scans, aerobic exercise tests, body composition scans, resistance exercise, a 24-hour research visit, 4 needle muscle biopsies, 2 needle fat biopsies, and an infusion of amino acids (the building blocks of muscles). Following the completion of the baseline visits, participants will be randomly placed into a resistance training group or a control group.1. Resistance Training Group: Participants put into the resistance training program will take part in a personalized resistance training program and meet with a personal trainer four times a week for three months. Following the three months of resistance training participants will repeat the baseline visits and will be completed with the study.
2. Control Group: Participants put into the control group are asked not to make any lifestyle changes for 3 months. Following the 3 months, they will come back for a repeat of the baseline measurements. At this point they will have the choice to take part in the resistance training program, followed by a third set of baseline measurements. Remuneration is provided. Study title: Molecular Mechanisms of Exercise Benefits to Insulin Resistant People
IRB #: 19-006273
Principle Investigator: Dr. K Sreekumaran Nair
Request an Appointment at Mayo Clinic Locations, travel & lodgingResearch Nov. 02, 2019 Share on: FacebookTwitter