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Study Finds Top Factors That Can Affect Your Future Quality of Life with MS

Medically reviewed by Heidi Moawad, M.D. — By Morgan Meissner, PhD on October 25, 2022Multiple sclerosis (MS) is a progressive neurological condition. It occurs when brain and spinal cord lesions develop and disrupt signaling between nerve cells. This can affect both physical and mental health and lead to symptoms involving mobility and sensory issues, visual disturbances, and pain. While many treatment options are available for MS, there’s currently no cure. The debilitating and progressive nature of the disease might negatively impact quality of life for some people living with MS. However, everyone living with MS experiences it differently. That means quality of life for people who have MS can vary from person to person. In this article, we examine research that identified important factors that can affect quality of life with MS.

How the study was set up

A 2022 study shared how quality of life differs among people living with MS and how it changes through the years. This study involved the results from more than 57,000 questionnaires completed by 4,888 people living with MS. Researchers began collecting these questionnaires in 1996. Responses spanned from 1 to 27 years since the participants’ MS diagnoses. Researchers aimed to identify factors affecting the quality of life of people living with MS. To identify the factors, researchers examined the impact of MS on participants’ physical health and how their mental health (the perception of their health and well-being) played a role. Researchers then divided the questionnaire results into physical health-related quality of life and mental health-related quality of life.

Factors that may impact physical health-related quality of life

The researchers worked on determining which factors were more common in people who had lower physical health-related quality of life scores compared with the others. They found that overall, a reduced physical health-related quality of life with MS occurred more often in people assigned male at birth and in people with:worse physical impairment and fatiguelonger diagnostic delaysadditional physical conditionsmore recent diagnosesdiagnoses during older adulthood These findings aligned with results from a 2016 study involving adults living with MS from Canada. This study also found that increased disability, fatigue, and having multiple physical health conditions linked to worse physical health-related quality of life in MS. In the 2022 study, most of the people experienced moderately to persistently low physical health-related quality of life throughout the course of disease. About 1 in 3 people seemed to experience a decline in physical health-related quality of life during the first 8 or 10 years of diagnosis that returned to a more typical level in the following years. In about 1 in 7 people, physical health-related quality of life remained as usual for the majority of their disease, with a decline not starting until the third decade after diagnosis.

Factors that may impact mental health-related quality of life

The researchers also worked on understanding which factors were more common in people who had lower mental health-related quality of life scores compared with the others. They found that those who consistently had the lowest mental health-related quality of life were more likely to have an annual income less than or equal to $50,000 and lack a higher education. Both of these factors appeared to negatively affect physical health-related quality of life as well. A reduced mental health-related quality of life with MS seemed to occur more often in nonwhite people, potentially due to socioeconomic or health inequities, and people with a:diagnosis at a younger ageworse physical impairmentmental health conditionmore recent diagnosis In the study, more than half of the people surveyed reported moderately to persistently low mental health-related quality of life. More than 1 in 5 people experienced an early decline in mental health-related quality of life that returned to a typical level within 10 years of diagnosis. Meanwhile, more than 1 in 4 people reported persistently unaffected mental health-related quality of life.

Social factors

These study findings showed that age, race, income, and education can be predictors for quality of life. This suggests that when considering social and socioeconomic factors, MS can affect each person’s quality of life differently. This may be particularly true when it comes to mental health. The way population characteristics impact quality of life with MS hasn’t been well-studied. However, other research shows that education and income may affect quality of life with MS. Understanding how social and socioeconomic factors impact people’s experiences with MS is important. It may help explain differences in the symptoms and progression of MS in many racial, ethnic, and age groups. Other social factors that may negatively affect quality of life for some people with MS include:job and income losslack of caregiver and social supportfamily tensionlack of education about MS

Improving quality of life with MS

Some of these factors that affect quality of life are out of your hands. However, there are still steps you can take to help improve quality of life with MS. The National Multiple Sclerosis Society recommends many tips for living well with MS, including:following healthy lifestyle habits, such as eating a balanced diet, avoiding smoking, and getting regular physical activitydeveloping healthy coping mechanisms and stress management techniquesfocusing on your emotional and spiritual well-beingkeeping your mind active through activities such as reading, writing, or doing puzzlesmaintaining your current friendships and building new ones, such as through an MS support group Sticking to your MS treatment plan is another way to help improve quality of life. The goal of MS treatment is to reduce disability and prevent disease progression. Since physical disability can be a strong predictor of reduced quality of life, sticking to your treatment plan may help improve or maintain your quality of life. If your current treatment plan is ineffective for you, talk with your neurologist about other options. Several treatment-related factors can also affect quality of life with MS, including:treatment effects on disease symptomsside effectsthe way of administering treatment

The takeaway

The physical and mental health effects of living with MS can be challenging and can negatively impact your quality of life in several ways. These include MS symptoms and disability, as well as social factors and treatment considerations. While it’s difficult to change some of these factors, there are steps you can take to help improve your physical and mental health and overall quality of life. Work with your neurologist to identify steps to help you best manage MS and improve your quality of life. Last medically reviewed on October 25, 2022

How we vetted this article

SourcesHistoryHealthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. We avoid using tertiary references. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.Amezcua L, et al. (2020). Race and ethnicity on MS presentation and disease course: ACTRIMS Forum, 2019.
ncbi.nlm.nih.gov/pmc/articles/PMC7160002/Berrigan LI, et al. (2016). Health-related quality of life in multiple sclerosis: Direct and indirect effects of comorbidity.
n.neurology.org/content/86/15/1417Farcalas E, et al. (2022). Health-related quality of life in people with multiple sclerosis: How does this population compare to population-based norms in different health domains?
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bmjopen.bmj.com/content/10/11/e041249Hosseini Z, et al. (2022). Barriers to quality of life in patients with multiple sclerosis: A qualitative study.
bmcneurol.biomedcentral.com/articles/10.1186/s12883-022-02700-7Living well with MS. (n.d.).
nationalmssociety.org/Living-Well-With-MSMortensen GL, et al. (2017). The impact of quality of life on treatment preferences in multiple sclerosis patients.
ncbi.nlm.nih.gov/pmc/articles/PMC5656344/O'Mahony J, et al. (2022). Physical and mental health–related quality of life trajectories among people with multiple sclerosis.
n.neurology.org/content/99/14/e1538Tollár J, et al. (2020). Exercise effects on multiple sclerosis quality of life and clinical-motor symptoms.
journals.lww.com/acsm-msse/Fulltext/2020/05000/Exercise_Effects_on_Multiple_Sclerosis_Quality_of.1.aspxOur experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Current Version Oct 25, 2022 By Morgan Meissner, PhD Edited By Kerry Weiss Medically Reviewed By Heidi Moawad, MD Copy Edited By Sofia Santamarina Share this articleMedically reviewed by Heidi Moawad, M.D. — By Morgan Meissner, PhD on October 25, 2022

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