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Surgery

Clinical trials

Below are current clinical trials.
146 studies in Surgery
(open studies only). Filter this list of studies by location, status and more.

Perioperative Enfortumab Vedotin EV Plus Pembrolizumab MK-3475 Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer MIBC MK-3475-B15 KEYNOTE-B15 EV-304

Scottsdale/Phoenix, Ariz. The purpose of this study is to assess the antitumor effectiveness and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. The dual primary hypotheses are preoperative EV + pembrolizumab and RC + PLND (Arm A) will achieve superior pathologic complete response (pCR) rate and perioperative EV and pembrolizumab and RC + PLND (Arm A) will achieve superior event free survival (EFS) compared with neoadjuvant gemcitabine + cisplatin and RC + PLND (Arm B).

A Study to Evaluate the Safety and Effectiveness of Adherus AutoSpray and Adherus AutoSpray ET Dural Sealant

Rochester, Minn., Jacksonville, Fla. The purpose of this study is to evaluate the safety and effectiveness of Adherus Dural Sealant when used in conjunction with standard methods of dural repair in spinal procedures. This trial uses the commercially available DuraSeal Exact (P080013b) as an active control. The trial is designed to demonstrate non-inferiority of Adherus Dural Sealant to DuraSeal Exact.
Subjects who have consented to participate in this study prior to undergoing spinal surgery and experience a durotomy, will be considered for study enrollment.

Accuracy of Patient-Specific Implants and Instrumentation in Total Hip Arthroplasty

Rochester, Minn. This is a prospective clinical trial examining only subjects who undergo THA with PSI. The purpose of this study is to compare the alignment accuracy of patient-specific implants versus traditional off-the-shelf implants in total hip arthroplasty using prior literature-derived data as controls.

A Study to Evaluate Novel Nipple Reconstruction Technique Using Nipple Sharing of a Half-Split Nipple in Female-to-Male Transgender Chest-Wall Contouring

Rochester, Minn. The purpose of this study is to describe a new surgical technique for nipple reconstruction in female-to-male transgender chest wall reconstruction and demonstrate its safety, patient satisfaction, aesthetic evaluation and complications. Subsequently, correlate these findings to assess overall surgical and clinical outcomes.

A Study to Evaluate the Venn Ovarian CAncer Liquid Biopsy

Jacksonville, Fla. The primary purpode of this study is to determine the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of the InterVenn Ovarian Cancer Liquid Biopsy among women with ovarian adnexal mass for which a surgery is planned.

A Study to Evaluate Support Services for Managing Urological Conditions

Scottsdale/Phoenix, Ariz. The purpose of this study is to assess if men and women seeking care for urological diseases have interest in support services in conjunction with standard of care.

A Study to Compare the Effectiveness of Adductor Canal Pain Catheters Following Total Knee Arthroplasty

Jacksonville, Fla. This study aims to compare postoperative pain levels between three (3) treatment groups, using the Numerical Rating Scale (NRS).

A Study of Intravital Microscopy IVM in Human Solid Tumors

Jacksonville, Fla. The purpose of this study is to determine the feasibility of performing HIVM in patients with deep space solid tumors during standard course of surgical resection.

Randomized Phase II III Trial of Adjuvant Radiation Therapy with Cisplatin Docetaxel-Cetuximab or Cisplatin-Atezolizumab in Pathologic High-Risk Squamous Cell Cancer of the Head and Neck

Rochester, Minn. This randomized phase II/III trial studies how well radiation therapy works when given together with cisplatin compared to docetaxel or cetuximab and docetaxel after surgery in treating patients with stage III-IV squamous cell head and neck cancer. Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy, such as cisplatin and docetaxel, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or transmit tumor killing molecules to them. It is not yet known whether radiation therapy is more effective when given with cisplatin, docetaxel, or cetuximab and docetaxel.

A Study to Create a Registry of Non-Fusion Spinal Deformity Correction in Adolescent Idiopathic Scoliosis

Rochester, Minn., Minneapolis, Minn. The primary purpose of this study is to evaluate the effectiveness of non-fusion surgical treatment of Spinal Deformity Correction in Adolescent Idiopathic Scoliosis. The Post Approval Study (PAS) is gathering data on the Tether device and it's efficacy and safety. Request an Appointment at Mayo Clinic Locations, travel & lodgingResearch Sept. 13, 2022 Share on: FacebookTwitter

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