Urology - Clinical trials - Mayo Clinic
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Clinical trials
Below are current clinical trials.
49 studies in Urology
(open studies only). Filter this list of studies by location, status and more. Perioperative Enfortumab Vedotin EV Plus Pembrolizumab MK-3475 Versus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle Invasive Bladder Cancer MIBC MK-3475-B15 KEYNOTE-B15 EV-304
Scottsdale/Phoenix, Ariz. The purpose of this study is to assess the antitumor effectiveness and safety of perioperative enfortumab vedotin (EV) plus pembrolizumab and radical cystectomy (RC) + pelvic lymph node dissection (PLND) compared with the current standard of care (neoadjuvant chemotherapy [gemcitabine plus cisplatin] and RC + PLND) for participants with MIBC who are cisplatin-eligible. The dual primary hypotheses are preoperative EV + pembrolizumab and RC + PLND (Arm A) will achieve superior pathologic complete response (pCR) rate and perioperative EV and pembrolizumab and RC + PLND (Arm A) will achieve superior event free survival (EFS) compared with neoadjuvant gemcitabine + cisplatin and RC + PLND (Arm B). A Study to Evaluate Contouring Organs at Risk for Treatment Planning
Scottsdale/Phoenix, Ariz., Jacksonville, Fla., Rochester, Minn. The purpose of this study is to determine: if the artificial intelligence (AI)-generated results are less arduous than manual tracing by radiation oncologist, and the non-inferiority of the quality of AI vs. manual tracing. These aims will be evaluated in a clinical environment to investigate the impact of an AI algorithm on the clinical workflow. Radiotherapy treatment planning requires precise calculations of radiation exposure, not only for the target volumes (tissue containing malignancy), but of nearby organs-at-risk (OARs), in which the exposure needs to be minimized. Manual segmentation of these organs is a time-consuming task with high interobserver variability. Producing these segmentations automatically will reduce the time required for treatment planning and improve the interobserver variability. A Study to Evaluate Support Services for Managing Urological Conditions
Scottsdale/Phoenix, Ariz. The purpose of this study is to assess if men and women seeking care for urological diseases have interest in support services in conjunction with standard of care. Use of Tamsulosin to Reduce the Incidence and Duration of Postoperative Urinary Retention Following Spine Surgery
Rochester, Minn. Postoperative urinary retention is a frequent complication of spinal surgeries and impacts a large portion of this population which results in increased morbidity as a result of increased number of catheterizations, urinary tract infections (UTIs) and prolonged hospital stays. With the addition of Tamsulosin, the investigators would anticipate a reduction in the incidence and duration of postoperative urinary retention and therefore a reduction in morbidity related to treatment of urinary retention as well as shortened hospital stays. Study of Validated Biomarkers in Urine for Patients with Adenocarcinoma of the Prostate
Rochester, Minn. The purpose of this study is to assess the accuracy of DNA marker candidates (individually and in combination) assayed from urine and prostatic fluid (collected following digital prostate massage) for detection of prostate cancer. Concomitant Renal and Urinary Bladder Allograft Transplantation
Rochester, Minn. Patients that need reconstruction or re-building of their urinary bladder are often limited to having a segment of their intestine used for that purpose. Using intestine is less than ideal as it is an absorptive, mucous producing tissue and placing this in constant contact with urine creates significant long term problems. In patients that require a kidney transplant and bladder reconstruction, this study seeks to use a bladder graft from a deceased donor rather than intestine. A Study of Proton Radiation Divided into Fewer Doses for Low Risk Prostate Cancer
Rochester, Minn., Scottsdale/Phoenix, Ariz. The purpose of this study is to compare the effects (good and bad) on patients with prostate cancer by comparing the standard dose of radiation therapy (44 treatments over 8½-9 weeks) with a higher daily dose of radiation (5 treatments over 1-2 weeks) to see if the effects of the treatments are similar or better. A Study of Nab-Paclitaxel as Maintenance Treatment After Cisplatin-Based Chemotherapy and Surgery for Patients with High-Risk Bladder Cancer
Scottsdale/Phoenix, Ariz. The purpose of this study is to evaluate nab-paclitaxel as maintenance therapy after cisplatin-based chemotherapy and surgery in treating patients with high-risk bladder cancer. Maintenance therapy, such as paclitaxel albumin-stabilized nanoparticle formulation, can help keep cancer from coming back after it has disappeared following initial chemotherapy. A Study of Advanced Magnetic Resonance Imaging of the Prostate Pelvis using Associated Image Processing with or without MRI Ultrasound Fusion Biopsy Guidance
Rochester, Minn. The purpose of this study is to assess the advantages of new image processing software to workflow and productivity. This software has been shown in the literature to improve cancer detection. Randomized Controlled Trial to Compare the Operative Outcomes and Complications of Mini-Percutaneous Nephrolithotomy mini-PCNL Versus Standard PCNL
Scottsdale/Phoenix, Ariz. The purpose of this study is to compare the operative outcomes and complications of mini-percutaneous nephrolithotomy (mini-PCNL) versus standard PCNL for renal stones. Request an Appointment at Mayo Clinic Locations, travel & lodgingResearch Sept. 24, 2022 Share on: FacebookTwitter Urology
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